Characterization of the coagulant activity of some snake venoms

Denson, K. W. E.; Russell, Findlay E.; D, Almagro; Bishop, Robert C.

doi:10.1016/0041-0101(72)90116-x

Cited by 60 publications

(16 citation statements)

References 3 publications

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“…Though the heated crude venom anticoagulant activity was not so strong, this may be due to involvement of the component with coagulant activity, thrombin like enzyme (3,9), which was separated from the drug-metabolizing en zyme inhibitory fraction (data not shown). It is reasonable that hemorrhagic and anti coagulant activities are included in the same fraction of the Habu venom, and the latter may aggravate hemorrhage by inhibition of hemostasis.…”

Section: Resultsmentioning

confidence: 99%

Heat Stable Protein with Anticoagulant and Smooth Muscle Contractile Actions Isolated from Habu (Trimeresurus flavoviridis) Venom

Aniya¹,

Sakanashi

Noguchi

et al. 1985

Japanese Journal of Pharmacology

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Abstract-The biological activity of a Habu (Trimeresurus flavoiridis) venom fraction with drug-metabolizing enzyme inhibitory action was studied. The venom fraction, which was isolated through Sephadex G-100 gel filtration and cation exchange chromatography on Amberlite CG50, caused an increase of vascular permeability and hemorrhage, but these actions were lost after heating at 70°C for 5 min. The fraction showed anticoagulant activity on citrated blood, and this activity remained after heating of the venom.Guinea pig ileum was contracted by treatment with nonheated or heated venom fraction, and these contractions were inhibited with atropine and potentiated with physostigmine. These results suggest that the drug-metabolizing enzyme inhibitor isolated from Habu venom involves the heat stable component with anticoagulant activity and smooth muscle contractile action.

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Section: Resultsmentioning

confidence: 99%

Heat Stable Protein with Anticoagulant and Smooth Muscle Contractile Actions Isolated from Habu (Trimeresurus flavoviridis) Venom

Aniya¹,

Sakanashi

Noguchi

et al. 1985

Japanese Journal of Pharmacology

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“…The capacity of plasma to form thrombin is also relevant in the blood coagulation system. These entire blood characteristic are affected by the toxic components of N. nigricollis venom (Denson et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanolic Leaf Extract of Euphorbia hirta on Snake Venom Induced Toxicity in Mice

Agusi¹,

Ogbunachi²

2018

TJANS

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“…La acción coagulante se debe a su poder de activar los factores de coagulación, convertir la protrombina en trombina y transformar el fibrinógeno en fibrina (Denson et al, 1972). La capacidad necrotizante del veneno resulta de la acción citotóxica de sus fracciones proteolíticas sobre los tejidos (Gutiérrez & Lomonte, 1989).…”

Section: Introductionunclassified

Estudio Morfológico e Histoquímico de las Glándulas Cefálicas de Bothrops alternatus (Ophidia, Viperidae)

Parpinelli¹,

Lopes²,

Sala³

et al. 2013

Int. J. Morphol.

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RESUMEN:El objetivo del presente trabajo fue estudiar la histología de las glándulas cefálicas de la víbora de la cruz (Bothrops alternatus), identificar los tipos celulares y caracterizar histoquimicamente el producto de secreción. Con esta finalidad fueron usados ejemplares machos adultos de B. alternatus. Después del sacrificio, las glándulas cefálicas fueron fijadas en formol neutro al 10% e incluidas en parafina. Los cortes, de 6 µm de espesor, fueron teñidos con hematoxilina y eosina, tricrómico de Masson y con técnicas histoquímicas para identificación de mucopolisacáridos y proteínas. Los resultados histológicos demostraron que las glándulas linguales, de veneno y accesorias son de tipo tubular, las glándulas labiales y premaxilar son tubuloacinares y la glándula de Harder es tubuloacinar compuesta. Las células mucosas de los adenómeros y conductos secretores de las glándulas linguales, labiales y premaxilar, así como las células de los conductos de la glándula de Harder, secretan sulfosialomucinas y mucopolisacáridos neutros. Las células mucoserosas de las glándulas linguales, labiales y premaxilar sintetizan mucopolisacáridos neutros, ácido siálico y radicales tirosina, cistina, cisteína, arginina y triptófano. Las células seromucosas de las glándulas de veneno, accesorias y de Harder producen polisacáridos neutros y radicales cistina, cisteína y triptófano, mientras que la glándula de Harder también sintetiza tirosina.

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Characterization of the coagulant activity of some snake venoms

Cited by 60 publications

References 3 publications

Heat Stable Protein with Anticoagulant and Smooth Muscle Contractile Actions Isolated from Habu (Trimeresurus flavoviridis) Venom

Heat Stable Protein with Anticoagulant and Smooth Muscle Contractile Actions Isolated from Habu (Trimeresurus flavoviridis) Venom

Effects of Ethanolic Leaf Extract of Euphorbia hirta on Snake Venom Induced Toxicity in Mice

Estudio Morfológico e Histoquímico de las Glándulas Cefálicas de Bothrops alternatus (Ophidia, Viperidae)

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