Characterization of the chemical composition of Adenostemma lavenia (L.) Kuntze and Adenostemma platyphyllum Cass

Fauzan, Aris Maulana; Praseptiangga, Danar; Hartanto, Rudy; Pujiasmanto, Bambang

doi:10.1088/1755-1315/102/1/012029

Cited by 5 publications

(10 citation statements)

References 20 publications

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“…The presence of 11αOH-KA and its derivatives in A. lavenia was reported in 1979 [16] and 1990 [29]. Since then, only one study from Indonesia has reported a comprehensive analysis of the ingredients in A. lavenia [30]. However, no 11αOH-KA was identified in those materials.…”

Section: Discussionmentioning

confidence: 99%

The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays

Hamamoto

Isogai

Maeda

et al. 2020

Foods

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Background: Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11αOH-KA) is a multifunctional biochemical found in some ferns, Pteris semipinnata, and its congeneric species. Although a number of therapeutic applications of 11αOH-KA have been proposed (e.g., anti-cancer, anti-inflammation, and skin whitening), the content of 11αOH-KA in these ferns is not high. Adenostemma lavenia (L.) O. Kuntze, an Asteraceae, has also been reported to contain 11αOH-KA. The decoction (hot water extract) of whole plants of A. lavenia is used as a folk remedy for inflammatory disorders, such as hepatitis and pneumonia, suggesting that 11αOH-KA may be the ingredient responsible for the medicinal properties of this plant. Methods: The anti-melanogenic activities of the water extracts of A. lavenia leaves and Pteris dispar Kunze (a cognate of P. semipinnata) leaves were compared in mouse B16F10 melanoma cells. The amount of 11αOH-KA was measured by using liquid chromatography spectrometry. C57BL/6J mice were treated with the water extract of A. lavenia leaf, and the blood concentration of 11αOH-KA was measured. The in vivo efficacy of the water extract of A. lavenia leaf was evaluated according to tis anti-melanogenic activity by monitoring hair color. Results: Although both the extracts (A. lavenia and P. dispar Kunze) showed high anti-melanogenic activities, only A. lavenia contained a high amount of 11αOH-KA, approximately 2.5% of the dry leaf weight. 11αOH-KA can be purified from A. lavenia leaves in two steps: water extraction followed by chloroform distribution. The treatment of mice with the water extract of A. lavenia leaf suppresses pigmentation in their hairs. Conclusions: Despite the small number of mice examined, the present preliminary result of the suppressed hair pigmentation suggests that the water extract of A. lavenia leaf and the ingredient that is possibly responsible for this—11αOH-KA—are new materials for oral cosmetics. The results may also be helpful in the future development of functional foods and methods to treat patients suffering from hyperpigmentation disorders, such as melasma.

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Section: Discussionmentioning

confidence: 99%

The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays

Hamamoto

Isogai

Maeda

et al. 2020

Foods

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“…The amino acid residues produced from the COX-2 structure showed no missing amino acid residues so the COX-2 protein could be used for the docking process. The compounds in A. Lavenia and M. calabura were referred to in literature [23][24]. Flavonoids, steroids, terpenoids, and saponins are observed in both plants [25].…”

Section: Receptors and Ligands Usedmentioning

confidence: 99%

Potential Adenostemma lavenia and Muntingia calabura Extracts to Inhibit Cyclooxygenase-2 Activity as a Therapeutic Strategy for Anti-inflammation: Experimental and Theoretical Studies

2022

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Continuous inflammation can cause new and more severe diseases, thus effective treatments are needed. One of the common inflammation treatments is given by reducing prostaglandins' production through the inhibition of COX-2 activity. This experiment aims to examine the potential application of plant extracts of Adenostemma lavenia and Muntingia calabura (Jamaica cherry) as anti-inflammatory agents in inhibiting COX-2 activity through in silico and in vitro assays. Molecular docking and molecular dynamics simulation were accomplished to evaluate the stability of the complex between COX-2 and ligands. The COX-2 inhibition was determined using the COX-2 Inhibitor Screening Assay KIT. Based on the docking results, the active compound from A. lavenia, ligand 1a,9b-dihydro-1H-cyclopropa[a]anthracene, has the lowest binding energy of -8.7 kcal/mol. In comparison, M. calabura contains 7-hydroxyflavone ligand with a Gibbs free energy of -9.1 kcal/mol. The molecular dynamics study demonstrates that COX-2 maintains its stability when forming interactions with selected compounds from all the tested extracts. The results of the COX-2 inhibition test showed that 96% EtOH extract of A. Lavenia at concentrations of 25 and 100 ppm had an inhibitory activity of 98%; meanwhile, 70% and 96% EtOH extracts of M. calabura at 1000 ppm concentration could inhibit COX-2 activity up to 100%. The results demonstrate that both plants show potential anti-inflammatory activity.

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“…Adenostemma lavenia merupakan salah satu jenis tumbuhan Asteraceae yang sering dianggap sebagai gulma/pengganggu namun memiliki kandungan yang bermanfaat. A. lavenia mengandung flavonoid, alkaloid, dan terpenoid yang tinggi (Kusumawati et al 2003;Fauzan et al 2017) yang berpotensi sebagai antioksidan (Stallings dan Lupo 2009). Berdasarkan penelitian yang telah dilaporkan, tumbuhan ini mengandung senyawa penghambat tirosinase dan antioksidan yaitu 11-hydroxylated kauranic acid (Ko et al 2008, Fauzan et al 2017.…”

Section: Pendahuluanunclassified

“…A. lavenia mengandung flavonoid, alkaloid, dan terpenoid yang tinggi (Kusumawati et al 2003;Fauzan et al 2017) yang berpotensi sebagai antioksidan (Stallings dan Lupo 2009). Berdasarkan penelitian yang telah dilaporkan, tumbuhan ini mengandung senyawa penghambat tirosinase dan antioksidan yaitu 11-hydroxylated kauranic acid (Ko et al 2008, Fauzan et al 2017. Selain A. lavenia, tumbuhan Asteraceae lain juga berpotensi untuk dikembangkan sebagai antioksidan dan antiglikasi.…”

Section: Pendahuluanunclassified

“…Hal ini menunjukkan bahwa yang bertanggung jawab terhadap aktivitas antioksidan tidak hanya senyawa golongan fenolik dan flavonoid, namun juga senyawa lain seperti terpenoid. Salah satu terpenoid yang dilaporkan memiliki aktivitas antioksidan yang tinggi dalam A. lavenia dan S. trilobata adalah 11-hydroxylated kauranic acid (Ko et al 2008;Ma et al 2013;Fauzan et al 2017). Selain itu, aktivitas flavonoid sebagai antioksidan bergantung pada struktur molekulnya (Bhaigyabati et al 2014).…”

Section: Aktivitasunclassified

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Potensi Beberapa Ekstrak Tumbuhan Asteraceae sebagai Antioksidan dan Antiglikasi

Budiarti¹,

Batubara²,

Ilmiawati³

2019

J Jamu Indo

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Tumbuhan Asteraceae dilaporkan mengandung metabolit sekunder tinggi yang aktif sebagai antioksidan. Senyawa antioksidan juga digunakan untuk mencegah penuaan/reaksi glikasi. Penelitian ini bertujuan menentukan aktivitas antioksidan dan antiglikasi 7 tumbuhan Asteraceae. Daun Adenostema lavenia, Ageratum conyzoides, Dichrocephala integrifolia, Galinsoga parvifolia, Synedrella nodiflora, Mikania micrantha, dan Sphagneticola trilobata masing-masing diekstraksi menggunakan air. Ekstrak kemudian ditentukan kandungan total fenol, flavonoid, dan aktivitas antioksidan menggunakan metode 1,1-difenil-2-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid (ABTS), serta aktivitas antiglikasi. Ekstrak dengan kadar total fenolik dan flavonoid tertinggi adalah ekstrak M. micrantha. Ekstrak A. lavenia memiliki aktivitas antioksidan terhadap DPPH tertinggi dengan nilai IC50 sebesar 121,82 μg/mL dan A. conyzoides tertinggi terhadap ABTS dengan kapasitas sebesar 4,51 mg trolox ekivalen (TE)/g ekstrak. Aktivitas antiglikasi tertinggi pada ekstrak G. parvifolia sebesar 90,67% yang tidak berbeda nyata dengan ekstrak A. lavenia (87,87%) dan S. trilobata (87,38%). Secara keseluruhan ekstrak A. lavenia dan S. trilobata baik dikembangkan sebagai antioksidan dan antiglikasi.

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Characterization of the chemical composition of Adenostemma lavenia (L.) Kuntze and Adenostemma platyphyllum Cass

Cited by 5 publications

References 20 publications

The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays

The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays

Potential <i>Adenostemma lavenia</i> and <i>Muntingia calabura</i> Extracts to Inhibit Cyclooxygenase-2 Activity as a Therapeutic Strategy for Anti-inflammation: Experimental and Theoretical Studies

Potensi Beberapa Ekstrak Tumbuhan Asteraceae sebagai Antioksidan dan Antiglikasi

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