Characterization of the blood oxygen level dependent hemodynamic response function in human subcortical regions with high spatiotemporal resolution

Kim, Junghwan; Taylor, Amanda; Himmelbach, Marc; Hagberg, G; Scheffler, Klaus; Ress, David

doi:10.3389/fnins.2022.1009295

Cited by 6 publications

(2 citation statements)

References 99 publications

(151 reference statements)

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“…Interestingly, the parametric patterns of significant age-related changes are generally reversed in subcortical areas, where the HRF is usually reported to be significantly faster and narrower than in cortical ROIs (Kim et al, 2022; Lewis et al, 2018). This is in line with (Lee et al, 2009), which represented prior findings of augmented subcortical perfusion in healthy older adults.…”

Section: Discussionmentioning

confidence: 99%

Revealing the spatial pattern of brain hemodynamic sensitivity to healthy aging through sparse DCM

Baron,

Silvestri,

Benozzo

et al. 2023

Preprint

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Age-related changes in the BOLD response could reflect neuro-vascular coupling modifications rather than simply impairments in neural functioning. In this study, we propose the use of a generative dynamic causal model (DCM) to decouple neuronal and vascular factors in the BOLD signal, with the aim of characterizing the whole-brain spatial pattern of hemodynamic sensitivity to healthy aging, as well as to test the role of hemodynamic features as independent predictors in an age-classification model. In this view, DCM was applied to the resting-state fMRI data of a cohort of 126 healthy individuals in a wide age range, providing reliable estimates of the hemodynamic response function (HRF) for each subject and each region of interest. Then, some features characterizing each HRF curve were extracted and used to fit a multivariate logistic regression model to predict the age class of each individual. Ultimately, we tested the final predictive model on an independent dataset of 338 healthy subjects selected from the Human Connectome Project Aging (HCP-A) and Development (HCP-D) cohorts. Our results entail the spatial heterogeneity of the age effects on the hemodynamic component, since its impact resulted to be strongly region- and population-specific, discouraging any space-invariant corrective procedures that attempt to correct for vascular factors when carrying out functional studies involving groups with different ages. Moreover, we demonstrated that a strong interaction exists between some specific hemodynamic features and age, further supporting the essential role of the hemodynamic factor as independent predictor of biological aging, rather than a simple confounding variable.

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Section: Discussionmentioning

confidence: 99%

Revealing the spatial pattern of brain hemodynamic sensitivity to healthy aging through sparse DCM

Baron,

Silvestri,

Benozzo

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Few studies have attempted to characterize the effect of vasculature on the HRF in the deep brain, though differences between the cortex and subcortex have been found (Duvernoy, 1999; Lewis et al, 2018; Tatu et al, 1998; Wall et al, 2009). Subcortical BOLD responses appear to peak earlier than those observed in the cortex and the post-stimulus undershoot normally associated with the canonical HRF is not always seen (Kim et al, 2022). Physiological noise is also more of an issue in the subcortex due to its proximity to large vessels (V. Singh et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The canonical stopping network: Revisiting the role of the subcortex in response inhibition

Isherwood

Kemp

Miletić

et al. 2023

Preprint

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This study investigates the functional network underlying response inhibition in the human brain, particularly the role of the basal ganglia in successful response inhibition. We provide evidence that the canonical inhibition pathways may not be recruited during successful response inhibition during the stop signal task (SST). Instead, subcortical nodes including the substantia nigra, subthalamic nucleus, thalamus, and ventral tegmental area are more likely to be activated during failed stop trials, suggesting that successful inhibition does not rely on the recruitment of these nodes. The findings challenge previous functional magnetic resonance imaging (fMRI) studies of the SST and suggest the need to ascribe a separate function to these networks. We also highlight the substantial effect smoothing can have on the conclusions drawn from task-specific GLMs. This study presents a proof of concept for meta-analytical methods that enable the merging of extensive, unprocessed or unreduced datasets. It demonstrates the significant potential that open-access data sharing can offer to the research community. With an increasing number of datasets being shared publicly, researchers will have the ability to conduct meta-analyses on more than just summary data.

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Short-Term Head-Out Whole-Body Cold-Water Immersion Facilitates Positive Affect and Increases Interaction between Large-Scale Brain Networks

Yankouskaya

Williamson²,

Stacey

et al. 2023

Biology

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An emerging body of evidence indicates that short-term immersion in cold water facilitates positive affect and reduces negative affect. However, the neural mechanisms underlying these effects remain largely unknown. For the first time, we employed functional magnetic resonance imaging (fMRI) to identify topological clusters of networks coupled with behavioural changes in positive and negative affect after a 5 min cold-water immersion. Perceived changes in positive affect were associated with feeling more active, alert, attentive, proud, and inspired, whilst changes in negative affect reflected reductions in distress and nervousness. The increase in positive affect was supported by a unique component of interacting networks, including the medial prefrontal node of the default mode network, a posterior parietal node of the frontoparietal network, and anterior cingulate and rostral prefrontal parts of the salience network and visual lateral network. This component emerged as a result of a focal effect confined to few connections. Changes in negative affect were associated with a distributed component of interacting networks at a reduced threshold. Affective changes after cold-water immersion occurred independently, supporting the bivalence model of affective processing. Interactions between large-scale networks linked to positive affect indicated the integrative effects of cold-water immersion on brain functioning.

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Characterization of the blood oxygen level dependent hemodynamic response function in human subcortical regions with high spatiotemporal resolution

Cited by 6 publications

References 99 publications

Revealing the spatial pattern of brain hemodynamic sensitivity to healthy aging through sparse DCM

Revealing the spatial pattern of brain hemodynamic sensitivity to healthy aging through sparse DCM

The canonical stopping network: Revisiting the role of the subcortex in response inhibition

Short-Term Head-Out Whole-Body Cold-Water Immersion Facilitates Positive Affect and Increases Interaction between Large-Scale Brain Networks

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