Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs*

McNeill, Conor J.; Overley, Beth; Shofer, F. S.; Kent, Michael S.; Clifford, Craig; Samluk, Marissa; Haney, Siobhan; Winkle, Thomas J. Van; Sørenmo, Karin U.

doi:10.1111/j.1476-5829.2006.00116.x

Cited by 33 publications

(44 citation statements)

References 43 publications

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“…A retrospective study of extraskeletal OSA (OES) in 169 dogs and a comparative evaluation of OSA in dogs and humans described metastasis in lymph nodes, lungs, kidneys, spleen, bone marrow, tegument, but did not mention the brain (9,14). In another study of OSA in 156 dogs, brain metastasis was noticed only in the Rottweiler, what 108 suggests that biological behavior of this breed may be different (12).…”

Section: Discussionmentioning

confidence: 99%

“…Despite the rarity even in dogs, Rottweilers are known to have more chances of having brain metastases than other breeds (12). The aim of this work is to report the occurrence of a CVA associated with an OSA metastasis in a dog.…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 30% of the human patients with any kind of cancer develop brain metastasis, however, only 0,8% of them all come from musculoskeletal tumors (osteo and rhabdomyosarcoma) or from soft tissue sarcomas, in this way, the metastasis of OSA to central nervous system is considered rare in all species, independent of primary origin be bone or extraosseous (12,16,19). Despite the rarity even in dogs, Rottweilers are known to have more chances of having brain metastases than other breeds (12).…”

Section: Introductionmentioning

confidence: 99%

“…It does not appear to be hereditary, although breed predilection like Great Dane, German Shepherd, St. Bernard, Irish Setter, and Boxer may occur. There is evidence that Rottweilers and Greyhounds have a high rate of disease occurrence (12,17). The treatment protocols for this neoplasm include radical surgery and chemotherapy, however, despite the treatment, these tumors usually cause death as a result of local or distant infiltration from the primary focus; an even worse prognosis is observed when lymph node metastasis is present, and studies indicate that 5 out of 200 dogs with OSA already have infiltration at this site at the time of amputation (14).…”

Section: Introductionmentioning

confidence: 99%

“…Osteosarcomas are the most common bone neoplasms in animals and humans (2,12). In dogs correspond to 85% of tumors of the appendicular skeleton and 75% of all bone tumors, focusing mainly in midsize to large male dogs, of all ages, with a higher occurrence between 7 and 8 years of age (7,18,20).…”

Section: Introductionmentioning

confidence: 99%

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Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Cristo¹,

Vargas²,

Biezus³

et al. 2017

Braz. J. Vet. Pathol.

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Cristo, et al.; Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol, 2017, 10(3), 105 -110 DOI: 10.24070/bjvp.1983-0246.v10i3p105-110 AbstractThe aim of this case report is to describe an uncommon hemorrhagic cerebrovascular accident (CVA) associated with an osteosarcoma (OSA) metastasis. Cerebrovascular accident (CVA) is the acute onset of a neurological deficit from any change in blood supply resulting from a pathological process, characterizing a stroke and among all the causes, the neoplastic thrombus of osteosarcoma, specifically, is the most infrequent in clinical practice. A seven-year-old female midsize mixed-breed dog was submitted to a forelimb amputation for showing an osteoblastic OSA in proximal humerus. Three weeks later, the patient presented uninterruptible seizure and coma, resulting in death. At necropsy, it was observed a friable and reddish mass in the left frontal cortex which, microscopically was constituted by OSA metastasis in association with multiple ruptures of blood vessels and focally extensive severe bleeding, which caused a CVA. At immunohistochemistry, neoplastic cells of the humerus and the brain metastasis were positive for vimentin and osteonectin, confirming the diagnosis of osteoblastic OSA. The reports about OSA metastasis on the brain are rare in animals and humans, what could be related to the low frequency and few diagnosis ante and post-mortem. As uncommon as the description of OSA metastasis to the brain, is the CVA associated to them, demonstrating that reporting cases related to these clinical and anatomopathological lesions are important for the scientific community.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Cristo¹,

Vargas²,

Biezus³

et al. 2017

Braz. J. Vet. Pathol.

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Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

et al. 2009

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Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual genetic backgrounds in shaping karyotypes of sporadic tumors is unknown. The genetic structure of purebred dog breeds coupled with their susceptibility to spontaneous cancers provides a robust model with which to address this question. We tested the hypothesis that there is an association between breed and the distribution of genomic copy number imbalances in naturallyoccurring canine tumors through assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma. Our findings reveal significant correlations between breed and tumor karyotypes that are independent from gender, age at diagnosis and histological classification. These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability.* Corresponding authors M. Breen,

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Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

Scott

Sarver

Gavin

et al. 2011

Bone

111

147

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The heterogeneous and chaotic nature of osteosarcoma has confounded accurate molecular classification, prognosis, and prediction for this tumor. The occurrence of spontaneous osteosarcoma is largely confined to humans and dogs. While the clinical features are remarkably similar in both species, the organization of dogs into defined breeds provides a more homogeneous genetic background that may increase the likelihood to uncover molecular subtypes for this complex disease. We thus hypothesized that molecular profiles derived from canine osteosarcoma would aid in molecular subclassification of this disease when applied to humans. To test the hypothesis, we performed genome wide gene expression profiling in a cohort of dogs with osteosarcoma, primarily from high-risk breeds. To further reduce inter-sample heterogeneity, we assessed tumor-intrinsic properties through use of an extensive panel of osteosarcoma-derived cell lines. We observed strong differential gene expression that segregated samples into two groups with differential survival probabilities. Groupings were characterized by the inversely correlated expression of genes associated with G2/M transition and DNA damage checkpoint and microenvironment-interaction categories. This signature was preserved in data from whole tumor samples of three independent dog osteosarcoma cohorts, with stratification into the two expected groups. Significantly, this restricted signature partially overlapped a previously defined, predictive signature for soft tissue sarcomas, and it unmasked orthologous molecular subtypes and their corresponding natural histories in five independent data sets from human patients with osteosarcoma. Our results indicate that the narrower genetic diversity of dogs can be utilized to group complex human osteosarcoma into biologically and clinically relevant molecular subtypes. This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets.

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Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs*

Cited by 33 publications

References 43 publications

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

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