2010
DOI: 10.1007/s11095-010-0158-y
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Characterization of the Ascending Colon Fluids in Ulcerative Colitis

Abstract: Variations in fluid composition of the ascending colon with activity and severity of ulcerative colitis may have an impact on the performance of orally administered products that are targeted to release the therapeutic agent in the colon.

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Cited by 31 publications
(29 citation statements)
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“…Procedures for obtaining approval for sample collection, methodology for sample collection and treatment, as well as collection of the liquid phase of colonic samples have been described previously . Upon collection, liquid phases were separated in small vials and stored at −70°C until a specific analysis required for the objectives of this study was performed.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Procedures for obtaining approval for sample collection, methodology for sample collection and treatment, as well as collection of the liquid phase of colonic samples have been described previously . Upon collection, liquid phases were separated in small vials and stored at −70°C until a specific analysis required for the objectives of this study was performed.…”
Section: Methodsmentioning
confidence: 99%
“…The physicochemical data of the liquid phase with high cholesterol content (HC sample) and the liquid phase with low cholesterol content (LC sample) investigated in this study are presented in Table . The high osmolarity of the HC sample implies that the ascending colon from which this particular sample had been collected may have not been fully recovered from the colon preparation procedure applied before colonoscopy (Table ) . Such possibility, however, does not decrease the usefulness of the HC sample because similar cholesterol levels have been measured in hyposmotic or isosmotic colonic contents .…”
Section: Methodsmentioning
confidence: 99%
“…These results corroborate observations in human patients with IBD, including neonatal necrotizing enterocolitis, Crohn’s disease, and ulcerative colitis, where elevated osmolarity in fecal fluid within the colon is noted (18, 19, 24). Furthermore, the fecal osmolarity elevation in Crohn’s disease patients shows a close correlation with disease severity (18, 19, 129). Under physiological conditions, both pro- and anti-inflammatory cytokines are present within the gastrointestinal tract, with the pro-inflammatory cytokines being kept in check by the anti-inflammatory cytokines.…”
Section: Inflammatory Bowel Diseasementioning
confidence: 97%
“…It is characterized by chronic inflammation of one or more regions of the gastrointestinal tract with reoccurring flare-ups (128, 129). Crohn’s disease and ulcerative colitis comprise the most common forms of IBD.…”
Section: Inflammatory Bowel Diseasementioning
confidence: 99%
“…For evaluation of colonic absorption, knowledge of drug solubility and dissolution rates in the region is required but relevant estimations remain problematic because of limited information on the conditions prevailing in the lower intestine . In recent years, our understanding on the environment in the lower intestine has been increased . Solubility of lipophilic APIs in the lumen of the ascending colon seems to be different than in the contents of stomach and/or upper intestine during fasting state .…”
Section: Introductionmentioning
confidence: 99%