Characterization of the Antimicrobial Peptide Penisin, a Class Ia Novel Lantibiotic from Paenibacillus sp. Strain A3

Isolated from a wide range of sources, the genus Paenibacillus comprises bacterial species relevant to humans, animals, plants, and the environment. Many Paenibacillus species can promote crop growth directly via biological nitrogen fixation, phosphate solubilization, production of the phytohormone indole-3-acetic acid (IAA), and release of siderophores that enable iron acquisition. They can also offer protection against insect herbivores and phytopathogens, including bacteria, fungi, nematodes, and viruses. This is accomplished by the production of a variety of antimicrobials and insecticides, and by triggering a hypersensitive defensive response of the plant, known as induced systemic resistance (ISR). Paenibacillus-derived antimicrobials also have applications in medicine, including polymyxins and fusaricidins, which are nonribosomal lipopeptides first isolated from strains of Paenibacillus polymyxa. Other useful molecules include exo-polysaccharides (EPS) and enzymes such as amylases, cellulases, hemicellulases, lipases, pectinases, oxygenases, dehydrogenases, lignin-modifying enzymes, and mutanases, which may have applications for detergents, food and feed, textiles, paper, biofuel, and healthcare. On the negative side, Paenibacillus larvae is the causative agent of American Foulbrood, a lethal disease of honeybees, while a variety of species are opportunistic infectors of humans, and others cause spoilage of pasteurized dairy products. This broad review summarizes the major positive and negative impacts of Paenibacillus: its realised and prospective contributions to agriculture, medicine, process manufacturing, and bioremediation, as well as its impacts due to pathogenicity and food spoilage. This review also includes detailed information in Additional files 1, 2, 3 for major known Paenibacillus species with their locations of isolation, genome sequencing projects, patents, and industrially significant compounds and enzymes. Paenibacillus will, over time, play increasingly important roles in sustainable agriculture and industrial biotechnology.Electronic supplementary materialThe online version of this article (doi:10.1186/s12934-016-0603-7) contains supplementary material, which is available to authorized users.

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“…Other lantibiotics include paenicidin A produced by P. polymyxa NRRL B-30509 [98] and penisin produced by Paenibacillus sp. strain A3 [99]. …”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Current knowledge and perspectives of Paenibacillus: a review

et al. 2016

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“…cremoris and L. monocytogenes (Lohans et al 2012). Paenicidin B produced by Paenibacillus terrae NRRL B-30644 with only two amino acid differences from paenicidin A showed antibacterial activity against L. monocytogenes and S. aureus (Lohans et al 2014 (Baindara et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Identification of the biosynthesis gene cluster for the novel lantibiotic paenilan fromPaenibacillus polymyxaE681 and characterization of its product

et al. 2017

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“…Other notable recent top-down RiPP discoveries include the first-in-class streptide, containing a carbon-carbon bond formed between lysine and tryptophan [51] and penisin, a lanthipeptide with activity against Gram-negative bacteria [52]. …”

Section: Examples Of Top-down Ripp Discovery Aided By Genomic Datamentioning

confidence: 99%

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

Hetrick

Donk

2017

Current Opinion in Chemical Biology

124

105

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In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.

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Characterization of the Antimicrobial Peptide Penisin, a Class Ia Novel Lantibiotic from Paenibacillus sp. Strain A3

Cited by 73 publications

References 63 publications

Current knowledge and perspectives of Paenibacillus: a review

Current knowledge and perspectives of Paenibacillus: a review

Identification of the biosynthesis gene cluster for the novel lantibiotic paenilan fromPaenibacillus polymyxaE681 and characterization of its product

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

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