Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain

Abstract

The present studies report for the first time the characterization of the affective component of acute postoperative pain using the mPEAP in a rodent model, which may facilitate development of improved understanding and treatment of postoperative pain.

Sensitivity of functional targeted neuropeptide evaluation in testing pregabalin analgesic efficacy in a rat model of osteoarthritis pain

“…However, there was a trend in deterioration for the MIA-placebo group, and the PEAP test was sensitive to detect an effect of analgesic medications: the PGB or carprofen-, and morphine-treated rats respectively, attenuated and deteriorated the PEAP behaviour. This is in accordance with previous reports which have demonstrated attenuated PEAP behaviour with single treatment of PGB in a neuropathic model, 50 of carprofen in an acute pain model, 51 and of morphine in a neuropathic 52,53 or an acute pain model. 51 It is interesting to note, that in the latter study, three rats that received morphine had to be excluded as they displayed stereotyped behaviours.…”

“…This is in accordance with previous reports which have demonstrated attenuated PEAP behaviour with single treatment of PGB in a neuropathic model, 50 of carprofen in an acute pain model, 51 and of morphine in a neuropathic 52,53 or an acute pain model. 51 It is interesting to note, that in the latter study, three rats that received morphine had to be excluded as they displayed stereotyped behaviours. 51 This was not the case in the present study, probably because morphine was administered after the OA pain induction, but it is clear that the morphine-treated rats deteriorated the PEAP behaviour.…”

“…51 It is interesting to note, that in the latter study, three rats that received morphine had to be excluded as they displayed stereotyped behaviours. 51 This was not the case in the present study, probably because morphine was administered after the OA pain induction, but it is clear that the morphine-treated rats deteriorated the PEAP behaviour. At D14, a trend to increased presence in the dark side of the operant test was noted for MIA-PGB, MIA-carprofen and MIA-placebo.…”

FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats

“…Home cage locomotor activity was assessed using the Opto-M3 Dual Axis system (Columbus Instruments, Columbus, OH) as previously described [34,35]. Following poly I:C/saline injection, animals were returned to their home cage and horizontal activity (total beam breaks) was recorded and presented as activity during the light phase (0-8 h post poly I:C/saline) and the dark phase (nocturnal activity: 14-22 h post poly I:C/saline).…”

Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1

“…Rats were presented with 2 water bottles in their home cage, one containing tap water and the other 1% (w/v) sucrose solution, for 4 days prior to (to confirm sucrose preference prior to experiment), and for 24 hours following LPS. Homecage locomotor activity was also assessed during this time using the Opto M3 Dual Axis system (Columbus Instruments, Columbus, OH) as previously described (Bree et al, 2016;Bree et al, 2015). On the day of the experiment rats were randomly assigned into one of four treatment groups: Vehicle-Saline, PF3845-Saline, Vehicle-LPS or PF3845-LPS (n = 8-10 per group).…”