Characterization of the acute effects of alcohol on asymmetry of inferior frontal cortex activity during a Go/No-Go task using functional near-infrared spectroscopy

Abstract

These findings suggest that the right IFC may mediate the acute effects of alcohol on inhibitory control. When the alcohol impairs the right IFC activity, subjects cannot inhibit the pre-potent responses for No-Go trials, resulting in enhanced false-alarm responses. Thus, this study successfully demonstrated the neural correlates of the alcohol effect in the right IFC activity during inhibitory control processes.

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study

“…Tsujii et al (2011) and Cui et al (2011) also adopted a similar block designed for go/no-go tasks, and treated the go task period as the baseline for contrast with the go/no-go task period when analyzing fNIRS signals. This paradigm was set primarily because of the difficulty with ADHD patients staying still without performing any tasks, which may lead to unexpected movements or hyperactive behavior.…”

Neural Mechanisms for Dual-Process Reasoning: Evidence from the Belief-Bias Effect

“…Indeed, recent NIRS studies have established the utility of NIRS in various cognitive tasks involving working memory (Ehlis et al, 2008;Tsujii et al 2007Tsujii et al , 2009bTsujii et al , 2010c, response inhibition (Boecker et al, 2007;Tsujii et al, 2011b), and semantic memory retrieval (Herrmann et al, 2003(Herrmann et al, , 2004Tsujii et al, 2009a). We believe that NIRS will improve understanding of the neural substrates of reasoning processes.…”

“…For example, response inhibition has been found to be associated with the right IFC activity in several tasks, including the go/no-go task (Chikazoe et al, 2007(Chikazoe et al, , 2009Chiu et al, 2008;Rubia et al, 2001;Tsujii et al, 2011b) and the stop-signal task (Aron and Poldrack, 2006;Hampshire et al, 2010;Rubia et al, 2001Rubia et al, , 2003. Furthermore, when subjects changed from one task to another (task-set switching), the right IFC activity was also enhanced (Cools et al, 2002;Smith et al, 2004Smith et al, , 2006Xue et al, 2008).…”

“…In general, enhanced oxy-Hb and reduced deoxy-Hb are associated with regional cortical activation. NIRS is noninvasive, robust against body movement and has been validated as a suitable technique for investigating neural mechanisms in psychological experiments (Tsujii et al, 2007(Tsujii et al, , 2009a(Tsujii et al, , 2009b(Tsujii et al, , 2010b(Tsujii et al, , 2010c(Tsujii et al, , 2011b.…”

The application of near infrared spectroscopy in nutritional intervention studies

“…As yet, however, the application of NIRS in a nutritional neuroscience setting has been limited by the shortcomings of the methodology and also by intrinsic difficulties in applying a relatively novel technique in a field that has only really flourished in the past few decades itself. For example, Tsujii et al (2011), in a placebo-controlled counterbalanced crossover trial, set out to assess the neural correlates of the effect of alcohol on response inhibition, a process that has previously been associated with activity in the inferior frontal cortex (IFC). These authors used NIRS to assess hemodynamic response in the IFC during a Go/No-Go task prior to and after consuming alcohol and were able to demonstrate for the first time the contribution of the right IFC in inhibitory control of pre-potent responses following alcohol.…”