Characterization of ternary phase diagrams by means of thermal and rheological analyses

Bonacucina, Giulia; Cespi, Marco; Mencarelli, Giovanna; Palmieri, G

doi:10.3109/03639045.2012.719905

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…4B). According to Bonacucina et al 36 and Kodama et al 37 , water in the interbilayer region that does not interact with polar head groups of surfactants shows a freezing temperature similar to the bulk free water. The freezing temperature depends on the water and surfactant content and the strength of the interaction.…”

Section: Resultsmentioning

confidence: 98%

Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions

Teeranachaideekul

Soontaranon

Sukhasem³

et al. 2023

Sci Rep

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Liquid crystals are appealing in pharmaceutical and cosmetic fields due to their unique structures that combine the properties of both liquid and solid states. Forming an emulsion into liquid crystals can be affected by a number of factors, including the emulsion composition and temperature. Changing the types and concentrations of surfactants could be another factor that affects liquid crystals. Currently, most liquid crystal research focuses on the nanostructure of liquid crystal systems without evaluating the efficacy of liquid crystals clinically. In this study, liquid crystalline emulsions made from camellia seed oil with four different surfactants (Olivem 1000, Polyaquol-2W, Nikkomulese LC, and Lecinol S-10 with Tween 80) were created. The liquid crystal emulsions were formulated in the form of oil-in-water (o/w) emulsions with Camellia oleifera seed oil serving as the main ingredient in the oil phase (10% w/w). All formulations exhibited liquid crystal characteristics with lamellar structures as determined by the polarized light microscopy and small-angle X-ray scattering with supporting data of the nanostructure from wide-angle X-ray scattering and differential scanning calorimetry (DSC). They all showed good stability under normal (room temperature) and accelerated conditions (4 °C and 40 °C) in long-term storage (6 months). Using the reconstructed human epidermis as a skin model, all formulations did not cause skin irritation. In the clinical trial, all formulations were able to reduce transepidermal water loss (TEWL) and increase skin hydration immediately after application. This lasted at least 10 h. All formulations showed distinct Maltese crosses under the polarized light microscope with a positive result for liquid crystals in wide angle X-ray scattering (WAXS) and small angle X-ray scattering (SAXS) methods. Moreover, among all formulations tested, Formulation D, which contained Lecinol S-10 and Tween 80 as emulsifiers, showed the most robust interaction between the surfactant and water molecules in the lamellar structure under DSC. The formulation was stable in long-term normal and accelerated conditions. Above all, Formulation D, which was formulated with Lecinol S-10 with Tween 80, had the best clinical result, was nonirritating to the skin, and can be used as a cream base in the pharmaceutical and cosmeceutical sectors.

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Section: Resultsmentioning

confidence: 98%

Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions

Teeranachaideekul

Soontaranon

Sukhasem³

et al. 2023

Sci Rep

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“…(7) shows the haemolysis (%) with respect to the tested volume of microemulsion or surfactant mixtures (µl). To this extent, it is known from the literature [29] that Tween ® 80 is a nonhaemolytic surfactant, differently to Span 80 that exhibits moderate haemolytic properties [30]. The calculated haemolysis (%) was found to be much lower than 50% for both the microemulsions (around 5-10%) and surfactant mixtures (around 10-15%).…”

Section: Haemolytic Assaymentioning

confidence: 93%

“…The final volume was adjusted to 1 ml with isotonic buffer. The negative control was prepared by suspending 25 µL of erythrocytes in 950 µL of isotonic buffer, while the positive control was obtained with the same procedure of the negative one but finally frozen at -20°C [29]. All the samples, including positive and negative controls, were gently shaken for 10 minutes at room temperature and centrifuged at 3000 rpm for 5 min.…”

Section: Hemolytic Assaymentioning

confidence: 99%

“…The phase behaviour of ternary systems is generally studied by building a ternary phase diagram, which reports the results of a large number of experiments [28,29]. However, a quicker screening of the factors influencing microemulsion formation can be performed by applying different type of design of experiments (DoE), such as factorial, fractional factorial, Hadamard or even central composite design.…”

Section: Formulation Of Microemulsionsmentioning

confidence: 99%

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Water-in-Oil Microemulsions for Protein Delivery: Loading Optimization and Stability

Perinelli

Cespi

Pucciarelli

et al. 2017

CPB

Self Cite

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After incorporation of the protein in the microemulsion, a decrease of its aqueous solubility was observed. However, the formulation remained stable over six months and the native-like state of the recovered protein was demonstrated by fluorescence spectroscopy Conclusion: This study demonstrated the feasibility of preparing microemulsions with the highest content of protein and their long-term stability.

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Phase behavior, microstructural transition, antimicrobial and antioxidant activities of a water-dilutable thymol microemulsion

Deng

Taxipalati

Sun

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Characterization of ternary phase diagrams by means of thermal and rheological analyses

Abstract: In conclusion, the knowledge of the state of water and of the viscoelastic characteristics of the systems allow a deeper understanding of the structural features of the ternary phase diagram.

Cited by 6 publications

References 22 publications

Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions

Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions

Water-in-Oil Microemulsions for Protein Delivery: Loading Optimization and Stability

Phase behavior, microstructural transition, antimicrobial and antioxidant activities of a water-dilutable thymol microemulsion

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