Characterization Of Temporal Trends Of Dengue Fever In Municipalities In The Brazilian Northeast Outback

Abstract

Introduction: Dengue fever is currently a major endemic health issue in the city of Brejo Santo, located in the Brazilian Northeast outback, due to the rising morbidity and mortality rates in the area. The mosquito Aedes aegypti, the main vector of dengue fever virus, is highly adapted to the domestic environment. Since 1981 Brazil has been living with epidemic outbreaks of dengue fever.

Clinical Manifestations Suggestive of Depression in Patients Served with Febrile Illness in Campo Grande (MS) and Dourados (Ms), Brazil

“…The World Health Organization (WHO) [1] considers the biomedical and social changes that justified the data shown in Table 1 and Table 2 mainly associated with the clinical signs of neuro-Dengue, Zika and Chikungunya and, generally, the development of depressive signs in the disease fever are related to immunological mechanisms activated in the excessive production of pro-inflammatory cytokines [15,21,16] , which have the function of inducing organic depression in the viral infectious process seen in this study [11,28,29] .…”

“…As for education, it should be noted that in this study a correct record was made in the compulsory notification forms of Dengue cases in Mato Grosso do Sul, in which 46% had completed high school, differing from the study by Santos et al [22], with more than 50% of registered cases ignored or left blank at the time of notification [19,24,22,27,20,15,21,16].…”

“…In this study, it was reinforced that 50% of the patients developed fatigue mainly in the initial period (V0), experienced in the somatic aspects (Table 3) that aggravate the depressive signs and symptoms. These manifestations occur because the infectious alterations are the result of the deposition of immunocomplexes, mainly in the acute phase in the central nervous system [29,27] , and thus, symptoms such as headache, convulsions with fever or delirium and insomnia accompanied by restlessness and irritability followed by other sensory depressive signs with behavioral disorders will be accentuated [15] , however, the clinical manifestations occurred in this study in a higher percentage in the chronic period in the initial acute phase of the illness period (Table 2). These symptoms are usually associated with thrombocytopenia or disseminated coagulopathy, and this occurs as a consequence of immunological reactions of the viral infection in Dengue, generally associated with perivascular inflammation [11,21].…”

“…It is important to consider that human well-being and happiness is directly linked to good health [8,14] , as a poor state of health can presume incapacity in day-to-day tasks [15,16].…”

“…And in addition to neuropsychiatric and lethal complications, mental life conditions serve to measure the individual's health burden with dengue, chronic and acute diseases [20,15,21,16]. In the literature, the report we have is that dengue significantly worsens the mental quality of individuals [20].…”