Characterization of T Cell Growth Factor Responsive Thymocytes in Guinea Pigs

Söder, Olof; Sandberg, Göran; Ernström, Ulf; Löthwall, Jan

doi:10.1007/978-1-4613-2463-8_85

Cited by 2 publications

(1 citation statement)

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“…One growth factor (TGP) has been identified [review in ref. 1] and on the basis of studies of DNA synthesis, mitogen stimulation, rosetting, PNA binding, cell volume and buoyant density, the target cell for this factor was shown to be an immunologically immature cell [2,3]. In vitro, TGP allowed the responsive cells to pass a restriction point in G] and to enter S phase and mitosis [4], In vivo, these cells constitute a major fraction of cycling thymo cytes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Growth Factors on the Proliferation of Thymocytes in Different Functional and Anatomical Compartments

Sandberg

Ernström

Söder

et al. 1987

Int Arch Allergy Immunol

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The intrathymic location of cells responding to the thymocyte growth peptide (TGP) was investigated in guinea pigs. Thymus cells were labelled by topical application of a fluorescein isothiocyanate solution, and the percentage of fluorescent cells analyzed by flow cytometry. Large cells forming rosettes with rabbit erythrocytes, known to respond to TGP, had a lower percentage of fluorescent cells than non-rosetting cells, which do not respond to TGP. If the TGP-responding cells are anatomically segregated in the guinea pig thymus, this might indicate that they are preferentially located in the deep, juxtamedullary part of the cortex, where one major proliferating compartment is situated.

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Section: Introductionmentioning

confidence: 99%