Characterization of t-Butoxycarbonyloxy-containing Polymer and Its Application to Color Filter

Higuchi, Youichi

doi:10.2494/photopolymer.17.61

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Different mathematical models may be applied for describing the kinetics of the drug release process from the hydrogel matrix; the most suited being the one which best fits the experimental results. The kinetics of DL release from HM formulations was determined by finding the best fit of the dissolution data (drug release vs. time) to distinct models: first‐order and Higuchi 27, 28 …”

Section: Methodsmentioning

confidence: 99%

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Ray¹,

Gils²,

Mohanta³

et al. 2009

J of Applied Polymer Sci

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In this study, interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA) were prepared by a non-conventional emulsion method without any added crosslinker, using benzoyl peroxide as initiator and sodium chloride (NaCl) as additive. The IPN hydrogel was characterized by using Fourier transformed infrared (FTIR) spectrophotometry, Thermo gravimetric analysis (TGA), and Scanning electron microscopy (SEM). (PVA-co-PAA)/ NaCl normal IPN hydrogel (H) were fabricated into hydrogel microspheres (HM) by modified emulsion crosslinking method using glutaraldehyde-saturated toluene as crosslinker and were loaded with Diltiazem hydrochloride (DL). The IPN hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM for-mulation A1 showed comparatively higher DL entrapment (79%) and better control over DL release up to 24 h. By comparing antihypertensive activity of DL loaded two formulations in normotensive rats, HM formulation A1 found more effective in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/ NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier. A single use of the prepared hydrogel microsphere system of DL can effectively control hypertension in rats. The system holds promise for clinical studies. V C 2009 Wiley Periodicals, Inc. J Appl Polym Sci 116: 959-968, 2010

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Section: Methodsmentioning

confidence: 99%

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Ray¹,

Gils²,

Mohanta³

et al. 2009

J of Applied Polymer Sci

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show abstract

“…The kinetics of ALF release from hydrogel formulations was studied by finding the best fit of the dissolution data (drug release vs. time) to distinct models: first‐order and Higuchi20, 21 where Q ∞ being the total amount of drug in the matrix and k 1 the first‐order kinetic constant. where k H represents the Higuchi rate constant.…”

Section: Methodsmentioning

confidence: 99%

Release study of alfuzosin hydrochloride loaded to novel hydrogel P(HEMA‐co‐AA)

Mohapatra

Ray²,

Swain

et al. 2007

J of Applied Polymer Sci

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Hydrogels are of great interest in delivering drugs through their polymeric network. Hydrogels of macroporous copolymer 2-hydroxy ethyl methacrylate (HEMA) with acrylic acid (AA) were prepared in the presence of N,N 0 -methylene-bis-acrylamide as crosslinker and benzoyl peroxide as initiator. The structure of the copolymer, hydrogel character, and biodegradability have already been discussed in our previous article (Mohapatra et al., Polym Polym Compos 2005, 13, 807) entitled P(HEMA-co-AA) as Novel Biodegradable Macroporous Hydrogel. The current study involves the in vitro and in vivo release of alfuzosin hydrochloride at pH 7.0 and 9.2, taking different concentrations of drug and hydrogel. The percentage of drug entrapment study was done and the stability study was also performed according to I.C.H. guidelines for a period of 6 months giving satisfactory results.

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“…The kinetics of 5-FU release from HN formulations was determined by finding the best fit of the dissolution data (drug release vs. time) to distinct models: first-order and Higuchi [47,48]:…”

Section: In Vitro Drug-release Studymentioning

confidence: 99%

Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel

Ray

Mohapatra

et al. 2008

Journal of Biomaterials Science, Polymer Edition

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Intravenous administration of 5-fluorouracil (5-FU) for colon cancer therapy produces severe systemic side-effects due to its cytotoxic effect on normal cells. The main objective of the present study was to develop novel oral site-specific delivery of 5-FU to the colon with less drug being released in the stomach or small intestine using biodegradable hydrogel, hydrogel nanoparticles and comparing the targeting efficiency of 5-FU to colon from both. Poly(acrylic acid-co-acrylamide) (P(AA-co-Am)) normal hydrogel and hydrogel nanoparticles (HN) were synthesized by free radical polymerization using N,N-methylene-bis-acrylamide (MBA) as cross-linker, potassium persulfate as reaction initiator and 5-FU was loaded. HN were found to be degradable in physiological medium and showed comparatively higher swelling in rat caecal medium (RCM). 5-FU entrapment was increased by increasing Am (wt%) monomer feed. In vitro release of 5-FU from normal hydrogel and HN in pH progressive medium, it was found that a AA/Am ratio of 25:75 showed higher release in RCM. The Higuchi model yielded good adjustment of in vitro release kinetics. A higher amount of 5-FU reached the colon in HN (61 +/- 2.1%) than normal hydrogel (40 +/- 3.6%) by organ biodistribution studies in albino rats.

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Characterization of t-Butoxycarbonyloxy-containing Polymer and Its Application to Color Filter

Cited by 5 publications

References 19 publications

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Release study of alfuzosin hydrochloride loaded to novel hydrogel P(HEMA‐co‐AA)

Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel

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