Characterization of surface charge and mechanical properties of chitosan/alginate based biomaterials

Verma, Devendra; Desai, Malav S.; Kulkarni, Namrata; Langrana, Noshir A.

doi:10.1016/j.msec.2011.08.005

Cited by 37 publications

(25 citation statements)

References 37 publications

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“…When mixed in aqueous phase at adequate pH levels, chitosan, and alginate combine spontaneously through strong electrostatic attraction to form a polyelectrolyte complex (PEC) . The carboxyl groups in the alginate interact with the amino groups in the chitosan, resulting in a material with a high swelling tendency in physiological fluids and improved stability .…”

Section: Introductionmentioning

confidence: 99%

Improvement of the mechanical properties of chitosan‐alginate wound dressings containing silver through the addition of a biocompatible silicone rubber

Pires

Moraes

2014

J of Applied Polymer Sci

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The benefits of associating chitosan with alginate for the production of wound dressings are well documented. However, the mechanical resistance of these devices is limited. This work aimed to improve the mechanical properties of chitosan‐alginate membranes both with and without the microbicide agent AlphaSan® RC2000 (silver sodium hydrogen zirconium phosphate) by incorporating the liquid silicone rubber Silpuran® 2130 A/B. Membranes containing AlphaSan® RC2000 but without Silpuran® 2130 A/B have increased opacity, thickness, and water absorption, but low stability in water and tensile strength. The silicone gel remained in the structure of the formulations even after successive washing steps and its inclusion in the membranes reduced their thickness and swelling in aqueous media, improving their homogeneity, adhesiveness, stability, tensile strength, and flexibility. Thus, the addition of Silpuran® 2130 A/B proved to contribute positively to many relevant, particularly mechanical, properties of chitosan‐alginate wound dressings whether or not they contained AlphaSan® RC2000. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41686.

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Section: Introductionmentioning

confidence: 99%

Improvement of the mechanical properties of chitosan‐alginate wound dressings containing silver through the addition of a biocompatible silicone rubber

Pires

Moraes

2014

J of Applied Polymer Sci

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“…The brine was analyzed by ICP-MS [24,25]. This technique is a standard and rapid method for analyzing metal anions or cations.…”

Section: Characterization and Toolsmentioning

confidence: 99%

Use of electrospun fiber mats for the remediation of hypersaline geothermal brine

Çelik¹,

Koc²,

Erdogan³

et al. 2017

Desalination and Water Treatment

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a b s t r a c tGeothermal brines display high contents of various metal ions that can adversely affect surface and groundwater resources. Nevertheless, it is possible to sequestrate these metals and use some of them in certain engineering applications. The aim of this study was to fabricate electrospun chitosan fiber mats and remove heavy metal cations from geothermal brine of the Tuzla geothermal field (TGF) by employing these mats. TGF is located on the Biga Peninsula in the northwestern part of Turkey. The brine of TGF has high salinity (EC > 91 mS/cm) and high temperature (reservoir temperature is 173°C). The results show that the concentrations of lithium ion in geothermal fluid ranges from 17 to 35 mg/L, with little seasonal variations. A horizontal electrospinning setup was employed to obtain a non-woven mat comprising submicron diameter chitosan fibers at 2.0 kV•cm −1 . This material was then utilized as a stable membrane for the removal of metal ions is present in the brine through sorption at 25°C overnight. The results showed that the chitosan fiber mats sequestrate various ions in the brine. Under the studied conditions, the material was capable of removing 46%, 44%, 50%, 44%, 40%, 67% and 48% of Li + , Mg 2+ , Ba 2+ , Sr 2+ , Mn 2+ , Ca 2+ and K + from the geothermal brine, respectively.

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“…The good biological properties of CS, which include low toxicity, high biodegradability, biocompatibility, and putative antimicrobial properties, has led to their extensive use in scaffolds and drug delivery systems . Accordingly, various biomaterials which combine CS and ALG have been reported in different physical forms such as beads, hydrogels, and sponges …”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Accordingly, various biomaterials which combine CS and ALG have been reported in different physical forms such as beads, hydrogels, and sponges. [16][17][18][19] The inclusion of different additives to CS/ALG sponges can modify their functional properties and biological responses. In the present article, we utilized CS and ALG to produce sponges but also a third biopolymer belonging to the family of glycosaminoglycans (GAGs), hyaluronic acid (HA).…”

Section: Introductionmentioning

confidence: 99%

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Orellana

Giacaman

Pavicic

et al. 2016

J Biomedical Materials Res

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The study of biomaterials by electrical charge scaling to explore the role of net charge on biocompatibility and suitability for tissue regeneration has been limited as has the search for products that could improve this first-rate variable. In the present study, we prepared sponges composed of chitosan/alginate (CS/ALG) with or without hyaluronic acid (HA) by mixing polymer stock solutions of different net electric charge ratios (n(+/) n(-) ), and then lyophilizing them to obtain porous materials. The electric charge ratios n(+/) n(-) studied were 0.3, 0.8, 1.0, and 2.5 for CS/ALG and 0.3, 1.0, 1.9, and 3.7 for CS/ALG/HA sponges. Under these conditions a role for net electric charge balance over sponge microstructure rearrangement, protection to dissolution, cellular proliferation, and cell-cell interactions was apparent, effects that were enhanced by copolymer modification with HA. Mass balance, electric charge, and specific products that influence both such as HA, have a potential in biomaterials for wound healing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2537-2543, 2016.

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Characterization of surface charge and mechanical properties of chitosan/alginate based biomaterials

Cited by 37 publications

References 37 publications

Improvement of the mechanical properties of chitosan‐alginate wound dressings containing silver through the addition of a biocompatible silicone rubber

Improvement of the mechanical properties of chitosan‐alginate wound dressings containing silver through the addition of a biocompatible silicone rubber

Use of electrospun fiber mats for the remediation of hypersaline geothermal brine

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

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