Characterization of substituted aryl meroterpenoids from red seaweed Hypnea musciformis as potential antioxidants

Chakraborty, Kajal; Joseph, Deepu; Joy, Minju; Raola, Vamshi Krishna

doi:10.1016/j.foodchem.2016.06.039

Cited by 32 publications

(22 citation statements)

References 23 publications

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“…370 Three meroterpenoids 769-771 with variable anti-oxidative activities were characterised from Hypnea musciformis. 371 Halogenated indoles are another commonly encountered structural type, with eleven polyhalogenated indoles 772-782 from Rhodophyllis membranacea, including six which were the rst isolation of bromo-chloro-iodo secondary metabolites, as exemplied by 776. 372 Further related compounds were four brominated indole related alkaloids 783-786 (Laurencia similis), 373 and bromophenol 787 (Odonthalia corymbifera).…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2018

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Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2018

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“…Seaweeds are known for their richness in polysaccharides, minerals, and certain vitamins [13]. Marine algae have been also recognized as potential source of antioxidants [14,15] and traditionally consumed as a readily available whole food, especially among coastal communities [16,17,18]. Fatty acids and enzymatic and non-enzymatic antioxidant properties of have been investigated in Caulerpa species [19,20,21,22].…”

Section: Introductionmentioning

confidence: 99%

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

et al. 2016

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Recently, there is a growing interest towards the development of strategies for invasive seaweed control and exploitation as source of secondary metabolites. Here, we investigated the potential of exploitation in biotechnology and recycling options in eradication programs of the lipidic extract of the Mediterranean invasive seaweed Caulerpa cylindracea (Chlorophyta). The chemical characterization was carried out by means of multinuclear and multidimensional NMR spectroscopy. The fatty acid profile of C. cylindracea assessed the presence of several types of molecules known for antioxidant activity such as carotenoids, chlorophylls, pheophytins, and sterols. The NMR spectroscopy showed also the characteristic signals of saturated, unsaturated, and free fatty acids as well as other metabolites including the biopolymer polyhydroxybutyrate. The lipidic extract exerted an antioxidant activity corresponding to 552.14 ± 69.13 mmol Trolox equivalent/g (ORAC) and to 70.3 ± 2.67 mmol Trolox equivalent/g (TEAC). The extract showed an antibacterial activity against several Vibrio species, suggesting its potential use in the control of diseases in mariculture. Our results show that C. cylindracea, representing a critical hazard in coastal areas, could be transformed into a gain supporting specific management actions to reduce the effects of human pressures.

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“…Likewise, highly oxygenated meroterpenoids with antioxidant property have been found from Kappaphycus alvarezii, a red macroalgae [64]. Hypnea musciformis has meroterpenoid like 2-(tetrahydro-5-(4-hydroxyphenyl)-4-pentylfuran-3-yl)ethyl-4-hydroxy benzoate which shows antioxidative properties comparable to gallic acid [65]. Meroterpenoids from ethanolic extract of Sargassum serratifolium have the capability to protect liver from the oxidative damage generated from prooxidant tert-butyl hydroperoxide [66].…”

Section: Meroterpenoidsmentioning

confidence: 99%

Algal Terpenoids: A Potential Source of Antioxidants for Cancer Therapy

Ferdous¹,

Yusof²

2021

Biochemistry

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In cancer treatment, increase in drug resistance and decrease in new chemotherapeutic drugs have become a pressing problem. Hence, searching for novel anticancer agents with less toxicity and high sensitivity is expanding gradually. Many preclinical and clinical studies indicate that natural antioxidants can help combating carcinogenicity and reduce the adverse effects on cancer therapy, when used alone or as adjuvant in chemotherapy. Consequently, marine algae pave the way for exploring more potential antioxidant compounds which have pharmaceutical importance. Algal terpenoids comprise a large group of bioactive compounds that have excellent antioxidative property and can be used as source of antioxidant in cancer therapy. This chapter summarizes the potential role of terpenoids from algal sources in inhibiting cancer cells, blocking cell cycle, hindering angiogenesis and metastasis as well as in inducing apoptosis.

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Characterization of substituted aryl meroterpenoids from red seaweed Hypnea musciformis as potential antioxidants

Cited by 32 publications

References 23 publications

Marine natural products

Marine natural products

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

Algal Terpenoids: A Potential Source of Antioxidants for Cancer Therapy

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