Characterization of stimuli-responsive and cross-linked nanohydrogels for applications in ophthalmiatrics therapy

Chen, Shihong; Jia, Huanhuan; Cui, Xuehui; Zhang, Yan; Wen, Yu; Ding, Yuanyuan; Xie, Qiuling; Lin, Yen-Hui; Xiao, Feng; Lin, Xinliang; Wu, Hao; Mo, Zhenjie; Zheng, Kangyu; Qiu, Jindi; Wen, Yuqin; Ni, Qingchun; Ban, Junfeng; Chen, Yanzhong; Lu, Zhufen

doi:10.1007/s13204-020-01450-7

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Consequently researchers have developed a variety of stimuli responsive DDSs (e.g., nanoparticles, hydrogels, and implantable materials) [45] that are stable when stored and transported and can effectively release drugs to the target sites after being stimulated [19]. Stimuli-responsive polymers are the focus of growing attention as they undergo physical or chemical changes in response to internal or external stimuli (examples of such stimuli include temperature, pH, ions, enzymes, and light [8,19,46]); and stimuli-responsive DDSs can control the release of drugs (e.g., increase the residence time of the drugs, promote drug targeting, and release the drugs on demand) [47][48][49][50]. DDSs responsive to exogenous triggers such as light are promising for clinical applications, as they are in part independent of the physiological conditions that may vary from one patient to another (e.g., enzymes and pH), and moreover, the release of drugs or therapeutic factors can be controlled by the intensity and duration of the external stimulation applied.…”

Section: Ocular Drug Delivery Routesmentioning

confidence: 99%

Light-responsive biomaterials for ocular drug delivery

Abdelmohsen

Copeland

Hardy

2022

Drug Deliv. and Transl. Res.

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Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload highlights the potential of such biomaterials for treating a variety of conditions. The translucency of eyes and advances of laser technology in ophthalmology make light-responsive delivery of drugs feasible. Importantly, light can be applied in a non-invasive fashion; therefore, light-triggered drug delivery systems have great potential for clinical impact. This review will examine various types of light-responsive polymers and the chemistry that underpins their application as ophthalmic drug delivery systems. Graphical abstract

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Section: Ocular Drug Delivery Routesmentioning

confidence: 99%

Light-responsive biomaterials for ocular drug delivery

Abdelmohsen

Copeland

Hardy

2022

Drug Deliv. and Transl. Res.

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“…Among these nanogels, temperature-sensitive gel represented the best behavior. The stimuli-responsive nanogels can be considered as stable systems that are useful for sustained and targeted drug delivery to the posterior segment of the eye [ 103 ].…”

Section: Nanoparticles As Biodegradable Nanocarriers For Cornea Drmentioning

confidence: 99%

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

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“…The carrier materials were hydrated and swollen during preparation, and their pH and osmotic pressure were adjusted to obtain uniform, non-aggregating NPs. 20 submit your manuscript | www.dovepress.com…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

<p>PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers</p>

Jiang¹,

Jia²,

Qiu³

et al. 2020

IJN

Self Cite

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The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), chitosan oligosaccharide and trehalose. Determination of the drug/nanoparticles interactions, characterization of the nanoparticles, in vivo ocular compatibility tests, comparisons of their corneal permeability and their pharmacokinetics in aqueous humor were carried out. Methods: All PLGA NPs were prepared by the single emulsion and evaporation method and the drug-nanoparticle interaction was studied. The physiochemical features and in vitro corneal permeability of NPs were characterized while the aqueous humor pharmacokinetics was performed to evaluate in vivo corneal permeability of NPs. Ocular compatibility of NPs was investigated through Draize and histopathological test. Results: The PLGA NPs with lactide/glycolide ratio of 50:50 and small particle size (molecular weight 10 kDa) achieved optimal drug release and corneal permeability. Surface modification with different oligosaccharides resulted in uniform particle sizes and similar drug-nanoparticle interactions, although 2-HP-β-CD/PLGA NPs showed the highest entrapment efficiency. In vitro evaluation and aqueous humor pharmacokinetics further revealed that 2-HP-β-CD/PLGA NPs had greater trans-ocular permeation and retention compared to chitosan oligosaccharide/PLGA and trehalose/PLGA NPs. No ocular irritation in vivo was detected after applying modified/unmodified PLGA NPs to rabbit's eyes. Conclusion: 2-HP-β-CD/PLGA NPs are a promising nanoplatform for localized ocular drug delivery through topical administration.

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Characterization of stimuli-responsive and cross-linked nanohydrogels for applications in ophthalmiatrics therapy

Cited by 7 publications

References 21 publications

Light-responsive biomaterials for ocular drug delivery

Light-responsive biomaterials for ocular drug delivery

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

<p>PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers</p>

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