2009
DOI: 10.1186/1471-2407-9-81
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Characterization of STAT3 activation and expression in canine and human osteosarcoma

Abstract: BackgroundDysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more malignant tumor phenotype. STAT3 phosphorylation has been demonstrated in a subset of human osteosarcoma (OSA) tissues and cell lines. OSA in the canine population is known to exhibit a similar clinical behavior and molecular biology when compared to its human counterpart, and is often used as a m… Show more

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Cited by 103 publications
(146 citation statements)
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“…We also treated the human rhabodomyosarcoma cells with a low molecular weight compound STA-21 or block STAT3 signaling by dominant-negative STAT3 mutant, both of which induced rhabdomyosarcoma cell growth inhibition and apoptosis (37,47). Persistently activated STAT3 was also found in canine osteosarcoma (48). Our current study extended previous findings to show that blocking constitutive STAT3 activation in rhabodomyosarcoma cells inhibited cell growth and induced apoptosis through newly developed small molecule inhibitors and other JAK2/STAT3 inhibitors.…”
Section: Discussionsupporting
confidence: 76%
“…We also treated the human rhabodomyosarcoma cells with a low molecular weight compound STA-21 or block STAT3 signaling by dominant-negative STAT3 mutant, both of which induced rhabdomyosarcoma cell growth inhibition and apoptosis (37,47). Persistently activated STAT3 was also found in canine osteosarcoma (48). Our current study extended previous findings to show that blocking constitutive STAT3 activation in rhabodomyosarcoma cells inhibited cell growth and induced apoptosis through newly developed small molecule inhibitors and other JAK2/STAT3 inhibitors.…”
Section: Discussionsupporting
confidence: 76%
“…Other research groups have reported similar results when indirectly and directly inhibiting survivin in osteosarcoma. In one recent article, inhibition of STAT3 activity (which caused downregulation of survivin expression) in canine and human osteosarcoma decreased cell proliferation and viability and induced caspase-3/7-mediated apoptosis in treated cells (39). Another group inhibited survivin in HeLa cells and observed caspasedependent cell death as well as mitotic failure, resulting in multinucleated cells, up to 8 and 16N (40).…”
Section: Discussionmentioning
confidence: 99%
“…In breast cancer cells and epithelial cells, STAT3 may modulates MEK5 and HSP27 protein expression [7,8]. In addition, STAT3 signaling may regulate the expression of MMP [4,[9][10][11][12], VEGF [4,11,12], and Smad [13,14]. However, STAT3-regulated genes are still unclear in HCC, so in this study, we investigated the STAT3-regulated genes in HCC cells.…”
mentioning
confidence: 99%
“…For example, some studies suggest that STAT pathway plays an important role in cell-cycle progression and resistance to apoptosis through the regulation of cyclin A [1], E [1,2], D1 [1,3], XIAP [1,3], Survivin [1,4], and caspase [1,5]. In prostate cancer cells, the activation of STAT3 may affect the telomerase activity [6].…”
mentioning
confidence: 99%