Characterization of Splenic Cells during the Early Phase of Infection with Neuropathogenic Mouse Hepatitis Virus

Carbohydrate structures, including Lewis X (Le(x)), which is not synthesized in mutant mice that lack α1,3-fucosyltransferase 9 (Fut9(-/-)), are involved in cell-cell recognition and inflammation. However, immunological alteration in Fut9(-/-) mice has not been studied. Thus, the inflammatory response of Fut9(-/-) mice was examined using the highly neurovirulent mouse hepatitis virus (MHV) JHMV srr7 strain. Pathological study revealed that inflammation induced in the brains of Fut9(-/-) mice after infection was more extensive compared with that of wild-type mice, although viral titers obtained from the brains of mutant mice were lower than those of wild-type mice. Furthermore, the reduction in cell numbers in the spleens of wild-type mice after infection was not observed in the infected Fut9(-/-) mice. Although there were no clear differences in the levels of cytokines examined in the brains between Fut9(-/-) and wild-type mice except for interferon-β expression, some of those in the spleens, including interferon-γ, interleukin-6, and monocyte chemoattractant protein 1, showed higher levels in Fut9(-/-) than in wild-type mice. Furthermore, Fut9(-/-) mice were refractory to the in vivo inoculation of endotoxin (LPS) compared with wild-type mice. These results indicate that Le(x) structures are involved in host responses against viral or bacterial challenges.

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Mice lacking α1,3‐fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens

Kashiwazaki

Kakizaki

Ikehara

et al. 2014

Pathology International

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Highly Neurovirulent Viruses Invade and Spread in the Brain Using the Host Reactions Triggered by Infection

Watanabe¹,

Kakizaki²

2017

Diagn Pathol Open

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Receptor-Independent Infection by Mutant Viruses Newly Isolated from the Neuropathogenic Mouse Hepatitis Virus srr7 Detected through a Combination of Spinoculation and Ultraviolet Radiation

et al. 2011

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Characterization of Splenic Cells during the Early Phase of Infection with Neuropathogenic Mouse Hepatitis Virus

Cited by 4 publications

References 13 publications

Mice lacking α1,3‐fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens

Mice lacking α1,3‐fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens

Highly Neurovirulent Viruses Invade and Spread in the Brain Using the Host Reactions Triggered by Infection

Receptor-Independent Infection by Mutant Viruses Newly Isolated from the Neuropathogenic Mouse Hepatitis Virus srr7 Detected through a Combination of Spinoculation and Ultraviolet Radiation

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