Characterization of Silver/Bovine Serum Albumin (Ag/BSA) nanoparticles structure: Morphological, compositional, and interaction studies

Food Nano- and Microconjugated Systems: The Case of Albumin–Capsaicin

“…The group of albumin proteins has been used for the preparation of nanoparticles, microparticles and encapsulates due to its well-defined primary structure combined with the advantage of enabling surface modifications with dyes, antibodies, antigens, polysaccharides and proteins under stoichiometric conditions which provide stability to the structure (Weber et al 2000a;Lewis et al 2006;Zhang et al 2008Zhang et al , 2009Gebregeorgis et al 2013). Bovine serum albumin (BSA; MW 66,000) and cationised BSA (cBSA) are highly water-soluble containing numerous functional groups suitable for conjugation (Hermanson 2008).…”

Unaffected features of BSA stabilized Ag nanoparticles after storage and reconstitution in biological relevant media

“…However, biological relevant media strongly induce Ag-NP aggregation due to the high ionic strength that reduces the electrical double layer around the NP [14]. Therefore, capping agents such as self-assembled monolayers [15], surfactants [16], polymers [17], dendrimers [18] and proteins [19][20][21] have been employed to protect Ag-NP from aggregation. Protein molecules not only are excellent stabilizing agent but also create biofunctionalized Ag-NP [22][23][24][25].…”

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

“…12 Importantly, serum proteins naturally found in the blood are chiefly responsible for the maintenance of blood pH, and are nontoxic, biodegradable, and nonimmunogenic in nature. 35,36 The current study shows that BSA can be used as a nanocarrier for the delivery of Rh2, owing to its easy availability and biocompatibility. Various albumin-based NPs for drug delivery have been synthesized by desolvation method, among which BSA confers the drug with a great dispersibility and biocompatibility, in addition to providing a multifunctional surface for conjugation with other targeting molecules.…”

“…30 Figure 5 shows the spherical shape and surface morphology of the BSA-Rh2 NPs with 30-50 nm size as determined by the FE-TEM. 36,37 The images of the Rh2-loaded albumin NPs showed a spherical morphology. This supported that incorporation in BSA proteins leads to the formation of spherical NPs and their size falls within the optimal size range for NPs for drug delivery applications.…”