Characterization of serum estradiol level and tissue estrogen receptor immunostaining with clinical response and reproductive factor changes in Chinese female patients with esophageal squamous cell carcinoma

Zhang, Dongyun; Ku, Jian-Wei; Liu, Ran; Wu, Hong-fang; Liang, Guina; Yan, Wei; Chen, Pei-Nan; Zhao, Xueke; Song, Liu‐Dong; Li, Yin; Yao, Jianchao; Song, Xin; Wang, Lidong

doi:10.1016/j.biopha.2017.07.020

Cited by 14 publications

(18 citation statements)

References 21 publications

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“…Early menopause increases the risk factors for esophageal squamous cell carcinoma ( 9 ). It has been shown that premenopausal female patients have a prolonged survival than postmenopausal patients and that female ESCC patients with higher serum estradiol level have a favorable survival rate ( 10 ). An epidemiological study of menopausal hormone therapy (MHT) confirmed that ever-users of MHT were at a decreased risk of esophageal adenocarcinoma, gastric adenocarcinoma, and esophageal squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The previous studies found that esophageal squamous cell carcinoma and adenocarcinoma tissues express ERs, including ERα and ERβ ( 10 , 28 , 29 ). Estrogen plays a protective role through ERs, and the patients with esophageal cancer who express ERβ in the nucleus have a better prognosis ( 10 , 28 ). Some studies have also suggested that ERα plays a protective role in esophageal cancer ( 12 , 30 ), which is consistent with our data, showing that ERα is highly expressed in EC109 but not ERβ.…”

Section: Discussionmentioning

confidence: 99%

“…The identified risk factors for esophageal cancer also cannot fully explain this gender difference and may be related to sex chromosome mechanism. However, the epidemiological studies (8)(9)(10) and some preclinical studies indicate that sex hormones might play an important role in esophageal cancer. Sex steroids such as estrogens contribute to the physiological maturation and cell proliferation of estrogendependent tissues, such as breast, ovary, and endometrium (11,12).…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

Wang

Liu

et al. 2020

Front. Endocrinol.

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Gender differences in esophageal cancer patients indicate that estradiol may have antitumor effects on esophageal cancer. The initiation of endoplasmic reticulum stress (ERS) can induce apoptosis in esophageal cancer cells. However, it is still unknown whether estradiol inhibits the development of esophageal cancer by activating ERS pathway. In this study, the gender difference in the development of esophageal cancer was observed by analyzing clinical data and the experimental tumor xenografts in mice. Meanwhile, we investigated the mechanism of ERS in estradiol-mediated inhibition of esophageal cancer using esophageal squamous cell carcinoma cell line EC109. The proportion of male patients with esophageal cancer was significantly higher than female patients. Meanwhile, male patients were prone to have adventitial invasion. The weight of transplanted tumors in female mice was significantly smaller than that in male mice. In vitro experiments showed estradiol inhibits the viability and migration of EC109 cells by increasing the expression of ERS-related proteins, whereas ERS inhibitor 4-PBA abolished the effects of estradiol. In conclusion, our data demonstrate that sex difference exists in the occurrence of esophageal cancer. Estradiol can inhibit the viability and migration of esophageal cancer cells through the activation of ERS, providing a novel insight for esophageal cancer development, treatment, and prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

Wang

Liu

et al. 2020

Front. Endocrinol.

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“…Estrogen is an important steroid hormone, which may play some important biological effects in some kinds of cancer, but the results are inconsistent [22][23][24]. In a study of Zhang et al indicated that female esophageal squamous cell carcinoma (ESCC) patients with higher serum estradiol level have a favorable survival than those with lower serum estradiol levels, indicating the protective effect of serum estradiol on ESCC [22]. While, antiestrogen use in 6655 breast cancer patients in the Geneva Cancer Registry had significantly lower subsequent lung cancer mortality [25].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Serum Estradiol and Lung Cancer in Chinese Population

Fu¹,

Lin²,

Wu³

et al. 2018

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To analyze the correlation between the serum estradiol and lung cancer in Chinese population, PubMed, the Cochrane database and the China National Knowledge Internet database as well as VIP, WANGFANG MED, Sino Med were comprehensively searched for related studies strictly according to the selection criteria. Statistical analysis was performed using Review Manager 5.3 software. 16 studies were included for analysis, of which there were 736 subjects in the lung cancer group, 544 ones in the healthy control group. The results of Meta-analysis showed that the serum estradiol levels were higher in the lung cancer group than in the control one (SMD=0.81, 95%CI 0.31-1.30, Z=3.20, P<0.01). Meanwhile, from the subgroup analysis, the level of serum estradiol was higher in male lung cancer group (SMD=0.62, 95%CI 0.03-1.21, Z=2.06, P<0.05), but not in the female lung cancer group (SMD=0.02, 95%CI -0.51-0.55, Z=0.06, P>0.05) compared to the healthy control groups. Therefore, the serum estradiol level in the patients with lung cancer is higher than that in the healthy control population, suggesting serum estradiol level may be associated with the pathogenesis of lung cancer and expected to become a marker for the diagnosis of lung cancer, especially in Chinese population.

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Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

Zhao

Song

et al. 2022

J Cancer Res Clin Oncol

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Purpose Some studies indicated that gender is associated with prognostic of cancer, However, currently the prognostic value of gender for gastric cardia adenocarcinoma (GCA) survival is unclear. The aim of our study is to reveal the influence of gender on the prognosis of patients with GCA. Patients and methods A total of 42,345 cases Chinese GCA patients were enrolled from our previously established GCA and esophageal cancer databases. The clinicopathological characteristics were retrieved from medical records in hospital. The follow-up was performed through letter, telephone or home interview. Among GCA patients, there were 32,544 (76.9%) male patients with the median age 62 years (range 17–97) and 9,801 (23.1%) female patients with the median age 61 years (range 17–95 years). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival. Cox proportional hazards model was used for competing risk analyses, hazard ratios (HRs) and 95% confidence intervals (CIs) were evaluated. Results Men had shorter GCA-specific survival than women by multivariate analysis (HR 1.114; 95% CI 1.061 to 1.169; P < 0.001). Whether premenopausal, perimenopausal or postmenopausal, the survival of women was better than that of men (premenopausal vs. male, P < 0.001; perimenopausal vs. male, P < 0.001; postmenopausal vs. male, P = 0.035). It was worth noting that in patients with stages I, II, III, and IV, female patients survive longer than male patients (P = 0.049; P = 0.011; P < 0.001; P = 0.044, respectively). Conclusion Gender is an independent prognostic factor for patients with GCA. In comparison with men, women have a significantly better outcome. Smoking and drinking may be protective factors for male GCA patients.

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Characterization of serum estradiol level and tissue estrogen receptor immunostaining with clinical response and reproductive factor changes in Chinese female patients with esophageal squamous cell carcinoma

Cited by 14 publications

References 21 publications

Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

Correlation Between Serum Estradiol and Lung Cancer in Chinese Population

Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

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