Characterization of self-healing hydrogels for biomedical applications

Karvinen, Jennika; Kellomäki, Minna

doi:10.1016/j.eurpolymj.2022.111641

Cited by 22 publications

(6 citation statements)

References 64 publications

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“…The authors have cited additional references within the Supporting Information. [59][60][61][62][63][64][65] (Dept. of Science & Technology, Govt.…”

Section: Discussionmentioning

confidence: 99%

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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The cross‐linker‐free hydrogels have gained attention due to their lack of need for chemically modified polymers, resulting in better biocompatibility. The hydrogel properties can be enhanced by altering physical forces such as electrostatics and H‐bonds. Tuning the physical interactions between polymers, salts, and plasticisers can unlock new horizons in material properties. This article examines four different salts and mixtures to determine their impact on gelatin‐alginate biomaterial design. Drug release, swelling, and rheological properties are represented using a 3‐D plot, and optimum samples are identified. It is concluded that kosmotropes yield better release and swelling results than chaotropes. The physical interactions of these salts with polymers are explained using DLS and FTIR/ATR studies, and these findings are corroborated with release, swelling, and rheological analyses. Another aspect of the biomaterial, self‐healing property, is also considered. A 3‐D plot is prepared using release kinetics, gel strength, and recovery percentage (three important factors for self‐healing hydrogels). Chaotropes are identified as better candidates for self‐healing behaviour. However, when considering gel strength, release, and self‐healing, kosmotropes are favourable. Hence, different salts can be selected based on the desired application for hydrogels. It is also concluded that electrostatic forces hinder the formation of H‐bonds between polymer chains.

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“…The authors have cited additional references within the Supporting Information. [59][60][61][62][63][64][65] (Dept. of Science & Technology, Govt.…”

Section: Discussionmentioning

confidence: 99%

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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“…Fourier Transform Infrared Spectroscopy (FTIR, NICOLET IS 10) was used to characterize the chemical structure of OPD, POGMA and PBAE polymers [24]. The infrared scanning range was 4000 − 500 cm ¹. OPD sample was prepared by grinding OPD powder with KBr and pressed to disc using a die.…”

Section: Semmentioning

confidence: 99%

Preparation of Biodegradable Chitosan Semi-Interpenetrating Network Hydrogel and Its Application for Gastric Retention

DONG,

ZHANG,

SHENG

et al. 2024

Preprint

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Gastric retention hydrogels represent a potential material with weight-loss effects and offer an effective solution to address the low bioavailability of drugs in pharmaceutical therapy. This study aims to develop a degradable hydrogel capable of prolonged retention in the stomach, facilitating both weight loss and drug release. Two degradable macromolecular crosslinking agents were synthesized, with acrylamide as the main monomer, mixed with chitosan solution for the preparation of a degradable hydrogel with a semi-interpenetrating network (sIPN) structure initiated by a redox initiator. The morphology and chemical structure of the prepared hydrogels were characterized using analytical techniques such as SEM and FTIR. In vitro drug release experiments demonstrated that the hydrogel achieved controlled drug release, extending the drug's retention time in the stomach. The swelling performance, biocompatibility and degradation properties of the hydrogel in simulated gastric fluid (SGF) were also evaluated. Results indicated that the hydrogel with crosslinking agent ratio 4:6 exhibited a swelling ratio of 2700%, excellent biocompatibility and a weight loss of 7% in SGF over 5 days. The 4:6 hydrogel had a compressive modulus greater than 13 kPa at 60% deformation, demonstrating resistance to gastric peristalsis. Therefore, the chitosan sIPN hydrogel holds promising potential for applications in weight loss and the treatment of gastric diseases.

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“…So far, multiple strategies based on either qualitative or quantitative evaluation have been employed to estimate the self-healing performance of dynamic hydrogels. 38 For example, when analyzing the reversible interactions within hydrogels, spectroscopic methods, such as Fourier transformation infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), and Raman spectroscopy, can be applied to present the dynamic nature of dynamic covalent bonds by demonstrating the transition between the bond states. Morphology characterization, primarily through macroscopy, optical microscopy, atomic force microscopy (AFM), and scanning electron microscopy (SEM), is also a major and simple way to estimate the self-healing properties.…”

Section: Characterization Of Self-healing Hydrogelsmentioning

confidence: 99%

“…So far, multiple strategies based on either qualitative or quantitative evaluation have been employed to estimate the selfhealing performance of dynamic hydrogels. 38 For example, when analyzing the reversible interactions within hydrogels,…”

Section: Characterization Of Self-healing Hydrogelsmentioning

confidence: 99%