Characterization of scrotal involvement in children and adolescents with IgA vasculitis

Buscatti, Izabel M.; Abrao, Henrique M.; Kozu, Kátia; Marques, Victor L.S.; Gomes, Regina Lúcia Elia; Sallum, Adriana Maluf Elias; Silva, Clóvis A.

doi:10.1186/s42358-018-0039-3

Cited by 15 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A lower frequency of elevated serum IgA in GI involvement has not been previously reported. Data in the literature is scarce; nevertheless, a recent study in children found significantly lower serum IgA in IgAV patients with scrotal involvement versus those without this manifestation [19]. And a study on biomarkers of childhood IgAV nephritis showed no significant differences in the serum IgA level comparing cases with and without nephritis [20].…”

Section: Discussionmentioning

confidence: 99%

Predicting gastrointestinal and renal involvement in adult IgA vasculitis

et al. 2019

View full text Add to dashboard Cite

BackgroundImmunoglobulin A vasculitis (IgAV) is still poorly defined in the adult population. We aimed to determine the predictors of gastrointestinal (GI) or renal involvement in adult IgAV.MethodsThe prospective study included histologically proven adult IgAV cases diagnosed between January 2013 and July 2019 at our secondary/tertiary rheumatology center. We evaluated the role of clinical and the laboratory parameters as markers predicting the GI or renal involvement in IgAV, using the multiple logistic regression analysis.ResultsDuring the 79-month observation period, we identified 214 new adult IgAV cases (59.3% males, median (interquartile range) age 64.6 (57.2–76.7) years). The GI tract and renal involvement developed in 58 (27.1%) and 83 (38.8%) cases, respectively (concurrently in 26 (12.1%) cases). In the multivariate logistic regression analysis, generalized purpura (OR 6.74 (95%CI 3.18–14.31)), the pre-treatment neutrophil to lymphocyte ratio (NLR) > 3.5 (OR 2.78 (95%CI 1.34–5.75)), and elevated serum IgA levels (OR 0.40 (95%CI 0.20–0.79)) were extracted as factors associated with GI complications, whereas current smoking (OR 3.23 (95%CI 1.50–6.98)), generalized purpura (OR 1.98 (95%CI 1.08–3.61)), elevated serum IgA (OR 2.25 (95%CI 1.21–4.18)), NLR > 3.5 (OR 1.96 (95%CI 1.02–3.77)), and marginally age (1.02 (95%CI 1.01–1.04)) emerged as factors associated with renal complications.ConclusionGeneralized purpura and pre-treatment NLR predicted both GI and renal involvement, whereas active smoking was associated with renal involvement, and the serum IgA level had a divergent effect on renal and GI involvement in adult IgAV.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting gastrointestinal and renal involvement in adult IgA vasculitis

et al. 2019

View full text Add to dashboard Cite

show abstract

“… 1 – 3 Orchitis was described as the presence of scrotal swelling and/or tenderness in physical exam and/or testicular Doppler ultrasound alterations. 2 The duration of orchitis was measured in days.…”

Section: Methodsmentioning

confidence: 99%

“…Nephritis was defined as hematuria >5 red blood cells/high power field or presence of red blood cells in the urinary sediment and/or proteinuria >0.1g/m 2 /day. Nephrotic syndrome was diagnosed according to edema, serum albumin <2.5g/L and proteinuria >1g/m 2 /day.…”

Section: Methodsmentioning

confidence: 99%

“…This gastrointestinal manifestation may be associated with serious complications, as bowel intussusception or gastrointestinal bleeding. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“…Of note, recurrent or intermittent colicky abdominal pain in IgA vasculitis were seldom described in previous case reports or case series. 1 , 2 , 7 – 11 However, to our knowledge, additional analysis comparing patients with versus patients without intermittent abdominal pain in the first month of IgA vasculitis were not carried out.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intermittent abdominal pain in IgA vasculitis

Buscatti

Simon

Viana

et al. 2022

Rev. paul. pediatr.

Self Cite

View full text Add to dashboard Cite

Objective: To assess intermittent abdominal pain in IgA vasculitis patients and its relation to demographic data, clinical manifestations and treatments. Methods: A retrospective cohort study included 322 patients with IgA vasculitis (EULAR/PRINTO/PRES criteria) seen at the Pediatric Rheumatology Unit in the last 32 years. Sixteen patients were excluded due to incomplete data in medical charts. Intermittent abdominal pain was characterized by new abdominal pain after complete resolution in the first month of disease. Results: Intermittent abdominal pain was observed in 35/306 (11%) IgA vasculitis patients. The median time between first and second abdominal pain was 10 days (3–30 days). The main treatment of intermittent abdominal pain included glucocorticoid [n=26/35 (74%)] and/or ranitidine [n=22/35 (63%)]. Additional analysis showed that the frequency of intermittent purpura/petechiae (37 vs. 21%; p=0.027) and the median of purpura/petechiae duration [20 (3–90) vs. 14 (1–270) days; p=0.014] were significantly higher in IgA vasculitis patients with intermittent abdominal pain compared to those without. Gastrointestinal bleeding (49 vs. 13%; p<0.001), nephritis (71 vs. 45%; p=0.006), glucocorticoid (74 vs. 44%; p=0.001) and intravenous immunoglobulin use (6 vs. 0%; p=0.036) were also significantly higher in the former group. The frequency of ranitidine use was significantly higher in IgA vasculitis patients with intermittent abdominal pain versus without (63 vs. 28%; p<0.001), whereas the median of ranitidine duration was reduced in the former group [35 (2–90) vs. 60 (5–425) days; p=0.004]. Conclusions: Intermittent abdominal pain occurred in nearly a tenth of IgA vasculitis patients, in the first 30 days of disease, and was associated with other severe clinical features. Therefore, this study suggests that these patients should be followed strictly with clinical and laboratorial assessment, particularly during the first month of disease course.

show abstract

Testicular infarction in an adult patient with systemic IgA vasculitis

Yaseen

2023

Clin Rheumatol

View full text Add to dashboard Cite

A 73-year-old male presented with skin rash, ankle pain, weight loss, abdominal pain, non-bloody diarrhea, and testicular pain.On examination, he was afebrile and normotensive. He had palpable purpura over the legs (Fig. 1A), tenderness and swelling in ankle joints, and diffuse tenderness in the abdomen and scrotum.He denied recent infection or vaccination, new medications, or recreational drug use.Age-appropriate malignancy screening was negative. Laboratory evaluation revealed normal blood counts, creatinine, and complement (C3/C4) levels. Acute hepatitis, rheumatoid factor, antinuclear, antineutrophil cytoplasmic, and cryoglobulin antibodies were negative. He had elevated C-reactive protein (12.3 mg/dL), erythrocyte sedimentation rate (100 mm/h), and IgA level (900 mg/dL, normal range 70-400 mg/dL). Infectious fecal studies were negative. Urinalysis with microscopic examination showed hematuria, proteinuria, and red blood cell casts (Fig. 1B).Scrotal sonogram showed a large hypoechoic area in the right testis with absent blood flow concerning infarction (Fig. 1C). Magnetic resonance enterography revealed wall * Kinanah Yaseen

show abstract

Characterization of scrotal involvement in children and adolescents with IgA vasculitis

Cited by 15 publications

References 21 publications

Predicting gastrointestinal and renal involvement in adult IgA vasculitis

Predicting gastrointestinal and renal involvement in adult IgA vasculitis

Intermittent abdominal pain in IgA vasculitis

Testicular infarction in an adult patient with systemic IgA vasculitis

Contact Info

Product

Resources

About