Characterization of reacting solutions of macromolecules by laser light scattering and Airfuge centrifugation

Automated refinement of macromolecular structures at low resolution using prior information

“…Poor diffraction quality from macromolecular crystals is a persistent problem: various types of short-range and longrange disorder induced by impurities, imperfect crystal-growth conditions and the natural conformational mobility of macromolecules result in the weakening of high-resolution observations, anisotropic diffraction and other problems (Chernov, 2003;Shaikevitch & Kam, 1981;Caylor et al, 1999). Poor crystal diffraction results in the corresponding data sets having a low information content.…”