Characterization of radiochromic poly(vinyl-alcohol)–glutaraldehyde Fricke gels for dosimetry in external x-ray radiation therapy

Gallo, Salvatore; Artuso, E.; Brambilla, M.G.; Gambarini, G.; Lenardi, Cristina; Monti, A.F.; Torresin, A.; Pignoli, E.; Veronese, I.

doi:10.1088/1361-6463/ab08d0

Cited by 39 publications

(39 citation statements)

References 37 publications

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“…The PVA-GTA-FG dosimeters were prepared using ultrapure water (resistivity 18.2 MΩ•cm), obtained by a water purification system (Milli-Q ® Direct, EMD Millipore, Germany), and using the following analytical grade compounds: 8.0 % w/w poly(vinyl alcohol) (PVA, Mowiol ® 18-88, Sigma Aldrich [48]), 0.5 mM ferrous ammonium sulfate hexahydrate (FAS, Carlo Erba); 0.165 mM Xylenol Orange tetra-sodium salt (XO, Riedel-de Haën), 21.2 mM of glutaraldehyde (GTA, Sigma Aldrich), and 25 mM of sulfuric acid (SA, Sigma Aldrich). The procedure for PVA-GTA Fricke gel dosimeters preparation, described in detail elsewhere [45], is here briefly summarized.…”

Section: Samples Preparationmentioning

confidence: 99%

“…Such composition proved to be characterized by a diffusion rate of ferric ions significantly lower that what achievable with natural gel matrices like gelatin from porcine skin and agarose [39,40]. For this reason, the interest toward PVA-GTA Fricke gel dosimetry is gaining importance, as attested by the increasing literature about this topic [41][42][43][44][45][46][47]. The PVA-GTA Fricke gels have, in fact, sensitivities comparable to the conventional gel dosimeters and they are promising tools in X-ray external radiotherapy applications.…”

Section: Introductionmentioning

confidence: 99%

“…The PVA-GTA Fricke gels have, in fact, sensitivities comparable to the conventional gel dosimeters and they are promising tools in X-ray external radiotherapy applications. It has been demonstrated that PVA-GTA Fricke gels are almost tissue equivalent over a very large photon energy range with independent dose rates and radiation energy [45].…”

Section: Introductionmentioning

confidence: 99%

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Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

et al. 2021

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Section: Samples Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

et al. 2021

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“…The preparation of PVA-GTA Fricke gel dosimeters was carried out considering the procedure described in detail elsewhere [36], and here briefly summarized.…”

Section: Samples Preparationmentioning

confidence: 99%

“…The recent development and optimization of a synthetic gel matrix prepared with Poly(vinyl-alcohol) (PVA) cross-linked by Glutaraldehyde (GTA) contributed to enhance the interest toward Fricke gel (FG) dosimeters [30][31][32][33][34][35][36]. In fact, compared to natural gelling agents, the use of PVA and GTA proved to guarantee higher levels of reproducibility in the manufactory process of the gel.…”

Section: Introductionmentioning

confidence: 99%

Temperature behavior of radiochromic poly(vinyl-alcohol)-glutaraldehyde Fricke gel dosimeters in practice

Gallo

Lizio

Monti

et al. 2020

J. Phys. D: Appl. Phys.

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The use of synthetic gel matrices prepared with poly(vinyl-alcohol) (PVA) cross-linked by glutaraldehyde (GTA) contributed to enhance the interest toward radiochromic Fricke gel (FG) dosimeters. As it occurs in several chemical dosimeters, the response of PVA-GTA Fricke gels could be affected by temperature. Aim of this work is to study the dependence of the dosimetric properties of PVA-GTA Fricke gel dosimeters both on the irradiation temperature and on temperature changes possibly occurring between the irradiation and readout phases. Such effects were investigated by means of magnetic resonance imaging (MRI) and optical absorbance (OA) measurements.

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First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

Kozicki

Bartosiak

Maras

et al. 2023

Adv Materials Technologies

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3D chemical dosimetry of radiotherapy is an interdisciplinary research related to medical physics, polymer and radiation chemistry, photochemistry, organic chemistry, computer science, oncology, materials engineering, and automation technology. It consists of a 3D high resolution tissue equivalent dosimeter, high resolution 3D reading, and software packages for fast processing of 3D measurement data. Research on 3D radiotherapy chemical dosimetry has been going on for almost forty years, starting with the first proposal of a 3D dosimeter -Fricke dosimetric solution in a physical gel matrix with magnetic resonance imaging (MRI) reading to record the spatial dose distribution. [1] Further research concerned both Fricke-gel dosimeters and other systems, such as polymer gel dosimeters, radiochromic gel and plastic dosimeters, and flexible dosimeters. Many dosimetric compositions have been proposed. As a general rule, each new 3D dosimeter has a specific acronym, usually derived from its components. Examples of 3D polymer gel dosimeters are as follows (the acronyms are associated with example references): BANG, [16] PAG, [17] PAGAT, [18] nMAG, nPAG, [19] MAGIC, [17,20] MAGIC-f, [21] NIPAM, [22,23] VIPAR, [24] VIP (VIPAR nd ), [25] VIC, [26] VIC-T, [26] VIP3-Pluronic F-127, [27,28] PAGAT2-Pluronic F-127, [29] PAB-IG nx , [14,30,31] NHMAGAT, [32] MAGADIT, [33] NMPAGAT. [34] Examples of 3D radiochromic dosimeters are as follows: PVA-GTA-XO-Fricke, [35,36] PVA-GTA-MTB-Fricke, [37] Fricke-XOgelatine, [38] Fricke-XO-Pluronic F-127, [10,13,39] TTC-Pluronic F-127, [40] NBT-Pluronic F-127, [41,42] KI-PVA, [43] KI-Pluronic F-127, [12] LCV-gelatine; [44] and 3D plastic radiochromic dosimeter: PRESAGE. [3,45,46] 3D flexible dosimeters have also been proposed: LMG-silicone, [47,48] FlexyDos3D, [49] as well as 3D lung-mimicking dosimeters: PAGAT-2-Pluronic F-127 foam, [11] foam based on methacrylic acid-gelatine infused with sodium dodecyl sulphate surfactant, [50] and methacrylic acid-gelatine gel with expanded polystyrene spheres. [51] It should be mentioned that alternative 3D reading techniques to MRI were also investigated, including computed tomography (CT), [22,23,52] ultrasonography, [53][54][55] and optical computed tomography (optical CT). [56,57] It has been shown that 3D dosimetry data This work reports on a new type of combined radiochromic ionizing radiation dosimeter for radiotherapy. The LCV-Pluronic F-127 serves for this purpose, which is a leuco crystal violet embedded in a physical hydrogel matrix of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) with additives. This dosimeter responds to ionizing radiation by developing a blue color with an intensity related to the radiation dose. The LCV-Pluronic F-127 dosimeter is improved for lower temperature stability by adding sodium chloride (NaCl). Subsequently, a method for manufacturing the LCV-Pluronic F-127 lung mimicking dosimeter is proposed. Next, the LCV-Pluronic F-127 3D composite dosimeter is elaborated, which cont...

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Characterization of radiochromic poly(vinyl-alcohol)–glutaraldehyde Fricke gels for dosimetry in external x-ray radiation therapy

Abstract: Italy) (4) Interdisciplinary Centre for Nanostructured Materials and Interfaces (CIMaINa), Milano (Italy) (5) Fondazione IRCCS "Istituto Nazionale dei Tumori", Milano (Italy)

Cited by 39 publications

References 37 publications

Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

Temperature behavior of radiochromic poly(vinyl-alcohol)-glutaraldehyde Fricke gel dosimeters in practice

First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

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