Characterization of Pyrethroid Resistance and Susceptibility to Coumaphos in Mexican<i>Boophilus microplus</i>(Acari: Ixodidae)

Miller, Robert J.; Davey, Ronald B.; George, John E.

doi:10.1093/jmedent/36.5.533

Cited by 143 publications

(90 citation statements)

References 12 publications

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“…(B.) microplus from Mexico (MILLER et al, 1999), but molecular studies have not been reported, and, with PBO's lack of complete specificity towards the cytochrome P450 family, a mechanism cannot be attributed to a specific P450. Finally, although a number of glutathione S-transferases have been identified in R.…”

Section: Pyrethroid Resistancementioning

confidence: 98%

“…(B.) microplus was Miller et al (1999) working with pyrethroid resistant tick populations from Mexico. Their work was verified by He et al (1999) who used gene sequencing to discover a specific amino acid substitution in Domain III (phenylalanine to isoleucine) of the R.…”

Section: Pyrethroid Resistancementioning

confidence: 99%

“…The Domain III phenylalanine to isoleucine change confers a very high level of resistance to permethrin, cypermethrin, and flumethrin in the homozygous state as seen in the highly acaricide-selected Mexican Corrales strain (>1000-fold, MILLER et al, 1999). The Domain II mutations are reported to convey lesser levels of resistance.…”

Section: Pyrethroid Resistancementioning

confidence: 99%

“…(B.) microplus had a significant metabolic resistance component within the population's overall 166-, 57-, and 16-fold resistance to permethrin, cypermethrin, and flumethrin, respectively (MILLER et al, 1999). Protein and molecular studies showed only a low percentage of individuals from Coatzacoalcos (8%) had a single copy of the Domain III sodium channel target site mutation (GUERRERO et al, 2001).…”

Section: Pyrethroid Resistancementioning

confidence: 99%

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Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Guerrero

Lovis

Martins

2012

Rev. Bras. Parasitol. Vet.

176

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Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick's body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide.Keywords: Cattle tick, resistance mechanisms, target site mutation, metabolism. ResumoA resistência aos acaricidas tornou-se amplamente difundida nos países onde os carrapatos bovinos, Rhipicephalus (Boophilus) microplus, são um problema. A resistência surge por meio de alterações genéticas em uma população de carrapatos que causam modificações no local de ação, aumento do metabolismo ou sequestro do acaricida, ou ainda redução na capacidade do acaricida em penetrar através das camadas protetoras do corpo do carrapato. Neste artigo, foram revisados os mecanismos moleculares e bioquímicos da resistência aos acaricidas que ocorrem em R. (B.) microplus. A partir de um ponto de vista dos mecanismos envolvidos, a resistência aos piretróides tem sido caracterizada em maior grau do que em qualquer outra classe de acaricida. Embora uma grande quantidade de pesquisas têm sido direcionada para a descoberta de mecanismos que causam resistência aos organofosforados, muito pouco é conhecido ao nível molecular, e essa resistência parece ser mantida por intermédio de um processo multifatorial e complexo. Os mecanismos de resistência para os demais acaricidas são bem menos compreendidos. Os alvos de ação do fipronil e das lactonas macrocíclicas são conhecidos, e os estudos dos mecanismos de ação envolvidos estão ainda em estágios iniciais. O alvo de ação do amitraz ainda não foi definitivamente identificado, e isso é limitante aos estudos dos mecanismos envolvidos na resistência a esse acaricida.Palavras-chave: Carrapato bovino, mecanismos de resistência, mutação no local de ação, metabolismo.

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Section: Pyrethroid Resistancementioning

confidence: 98%

Section: Pyrethroid Resistancementioning

confidence: 99%

Section: Pyrethroid Resistancementioning

confidence: 99%

Section: Pyrethroid Resistancementioning

confidence: 99%

See 2 more Smart Citations

Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Guerrero

Lovis

Martins

2012

Rev. Bras. Parasitol. Vet.

176

View full text Add to dashboard Cite

show abstract

“…The Mexican strains were challenged either with coumaphos (Tuxpan, San Roman, Caporal, and Pesqueria) or permethrin (Coatzcolcos and San Felipe) to maintain their resistance to the respective acaricide. Resistance proÞles of these tick strains to other acaricides have been described in previous accounts (Miller et al 1999;Li et al 2003Li et al , 2004.…”

Section: Methodsmentioning

confidence: 64%