“…Several doses of the substrate (Non-radioactive olsalazine), were given in the range of zero to 1000 μg and then administered intravenously for two hours before the administration of [ 131 I]iodoolsalazine. The percent uptake of the colon (target organ, ulcerative) was predestined at 2 hours post-injection of [ 131 I]iodoolsalazine (n = 5) [48][49][50][51][52][53][54][55][56][57][58][59][60][61].…”
Ulcerative colitis (UC) is a chronic, regressive natural disease. The use of conventional diagnostic procedures such as magnetic resonance imaging, ultrasonography, and X-rays during the dormant and early stages of the disease does not aid in diagnosing the disease. As a result, a novel design, such as labelled compounds, were used to image ulcerative colitis disease. In this study, olsalazine was labeled with [ 125/131 I] and the labelling parameters were adjusted to obtain a high radiochemical yield (98.5%). In addition, the olsalazine radiotracer gave 96.0% purity in rate serum for up to twelve hours before it started to degrade at twenty-four hours, and it was stable also, in saline for up to twentyfour hours. Molecular docking was used to assess a complex's affinity for its biological target, and the PPAR receptor. The biological assessment was also performed in mice models of both standard and ulcerative colitis. The results demonstrated that [ 125/131 I] iodoolsalazine had a high uptake of 79.5% (ID/g) at 120 minutes post-injection and is still high to 77% at 24 hours. So, the labelled compound, [ 125/131 I] iodoolsalazine, could be considered a new potential selective radiotracer for preclinical diagnostic research of ulcerative colitis.
“…Many techniques by destructive procedures such as ICP-AES, ICP-MS, Atomic Absorption, and UV, have been used to determine the elemental compositions in the solid samples [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Neutron activation analysis (NAA) stands out among the highly precise and sensitive analytical methods currently in use in that it does not require prior sample preparation, such as acid digestion, which greatly improves both precision and accuracy in determining the content of major and trace elements in rocks [3,30].…”
The current work was carried out to characterize rock samples of mudstone, sand, and limestone collected at different depths from Northwestern Coast, Ras El-Hekma -Egypt. The samples were subjected to neutron activation analysis to determine the elemental composition and to better understand the geochemistry of the rocks. The abundance of 17 elements was determined. Bivariate and multivariate statistical analyzes were performed to investigate the origin of rocks and common geochemical characteristics (i.e., type, origin, geological history, major and trace composition, weathering, and alteration). The normalized results obtained showed that the abundances of Ca and Sr were significant compared to the corresponding values in the literature. The enrichment factor (EF) was calculated to obtain more information about the sources of the increased abundances of the metals. The results obtained can provide baseline data for the surveyed region and can be utilized by the government, policymakers, and interested parties for future research and development endeavors and planning.
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