Laser protection for optical components, particularly those in high-power laser systems, has been a major concern. LaSrTiO with its good optical and thermal properties can be potentially applied as a high-temperature optical protective coating or high-reflectivity material for optical components. However, the high-power laser ablation behavior of plasma-sprayed LaSrTiO (x = 0.1) coatings has rarely been investigated. Thus, in this study, laser irradiation experiments were performed to study the effect of high-intensity continuous laser on the ablation behavior of the LaSrTiO coating. The results show that the LaSrTiO coating undergoes three ablation stages during laser irradiation: coating oxidation, formation and growth of new structures (columnar and dendritic crystals), and mechanical failure. A finite-element simulation was also conducted to explore the mechanism of the ablation damage to the LaSrTiO coating and provided a good understanding of the ablation behavior. The apparent ablation characteristics are attributed to the different temperature gradients determined by the reflectivity and thermal diffusivity of the LaSrTiO coating material, which are critical factors for improving the antilaser ablation property. Now, the stainless steel substrate deposited by it can effectively work as a protective shield layer against ablation by laser irradiation.