Characterization of plant polysaccharides from Dendrobium officinale by multiple chromatographic and mass spectrometric techniques

Ma, Huiying; Zhang, Keke; Jiang, Qing; Dai, Diya; Li, Hongli; Bi, Wentao; Chen, David D. Y.

doi:10.1016/j.chroma.2018.03.006

Cited by 38 publications

(20 citation statements)

References 41 publications

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“…CDP is also a kind of polysaccharide extracted from herbs, we suspect that the opposite effect of CDP may be related to the structural differences between CDP and other polysaccharides. Polysaccharides are formed by polymerization of monosaccharides but are variable in monosaccharide type, monosaccharide composition, glycosidic bond, side‐chain structure and molecular weight; these factors are thought to determine their biological functions . Existing studies have proposed the structure of CDP and suggested that CDP structure subsequently influences its function .…”

Section: Discussionmentioning

confidence: 99%

Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO‐1 pathway

Huang

et al. 2020

J Cellular Molecular Medi

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As a main part of pigmentation disorders, skin depigmentation diseases such as vitiligo and achromic naevus are very common and get more attention now. The pathogenesis of depigmentation includes melanocyte dysfunction and loss, which are possibly caused by heredity, autoimmunity and oxidative stress. Among them, oxidative stress plays a key role; however, few clinical treatments can deal with oxidative stress. As reported, Cistanche deserticola polysaccharide (CDP) is an effective antioxidant; based on that, we evaluated its role in melanocyte and further revealed the mechanisms.In this study, we found that CDP could promote melanogenesis in human epidermal melanocytes (HEMs) and mouse melanoma B16F10 cells, it also induced pigmentation in zebrafish. Furthermore, CDP could activate mitogen-activated protein kinase (MAPK) signal pathway, then up-regulated the expression of microphthalmiaassociated transcription factor (MITF) and downstream genes TYR, TRP1, TRP2 and RAB27A. Otherwise, we found that CDP could attenuate H 2 O 2 -induced cytotoxicity and apoptosis in melanocytes. Further evidence revealed that CDP could enhance NRF2/HO-1 antioxidant pathway and scavenge intracellular ROS. In summary, CDP can promote melanogenesis and prevent melanocytes from oxidative stress injury, suggesting that CDP helps maintain the normal status of melanocytes. Thus, CDP may be a novel drug for the treatment of depigmentation diseases. K E Y W O R D S Cistanche deserticola polysaccharide, depigmentation disease, melanocyte, melanogenesis, NRF2, oxidative stress S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Hu Y, Huang J, Li Y, et al. Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO-1 pathway.

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Section: Discussionmentioning

confidence: 99%

Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO‐1 pathway

Huang

et al. 2020

J Cellular Molecular Medi

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“… 2016 ; Ma et al. 2018 ). Notably, the polysaccharide content was highly associated with the production origin, growing years, harvest season, storage time, processing method, and different part of D. officinale (Teixeira da Silva et al.…”

Section: Dop-major Bioactive Components Of D Officinalementioning

confidence: 99%

“…In addition, biological extraction using enzyme and physical extraction by ultrasonic wave and microwave are also feasible (Tang et al 2017). After the extraction process, ion-exchange chromatography and gel filtration chromatography are usually used for purification (Chen et al 2016;Ma et al 2018). Notably, the polysaccharide content was highly associated with the production origin, growing years, harvest season, storage time, processing method, and different part of D. officinale (Teixeira da Silva et al 2016).…”

Section: Dop-major Bioactive Components Of D Officinalementioning

confidence: 99%

Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review

Guo

et al. 2020

Pharmaceutical Biology

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Context: Dendrobium officinale Kimura et Migo (Orchidaceae) is a naturally occurring precious traditional Chinese medicine (TCM) originally used in treating yin-deficiency diseases. The main active substances of Dendrobium officinale are polysaccharides (DOP). Recent findings highlighted the potential of DOP as a promising natural material for medical use with a diversity of pharmaceutical effects. Objective: In this review, we provide a systematic discussion of the current development and potential pharmacological effects of Dendrobium officinale polysaccharides in dermatology. Methods: English and Chinese literature from 1987 to 2019 indexed in databases including PubMed, PubMed Central, Web of Science, ISI, Scopus and CNKI (Chinese) was used. Dendrobium officinale, Dendrobium officinale polysaccharides, phytochemistry, chemical constituents, biological activities, and pharmacological activities were used as the key words. Results: Dendrobium officinale polysaccharides have been found to possess hair growth promoting, skin moisturising and antioxidant effects, which are highly valued by doctors and cosmetic engineers. We highlighted advances in moisturising and antioxidant properties from in vivo and in vitro studies. Dendrobium officinale polysaccharides exhibited strong antioxidant effects by decreasing free radicals, enhancing antioxidant system, inhibiting nuclear factor-kappa B and down-regulating inflammatory response. Conclusions: Our review is a foundation to inspire further research to facilitate the application of Dendrobium officinale polysaccharides in dermatology and promote active research of the use of TCM in dermatology.

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“…In order to accurately distinguish the dendrobe, DNA molecular labeling techniques are used to identify dendrobe with unobvious microscopic features [ 13 , 14 ]. In recent years, with the development of chromatography technology, it has also been applied to the identification of dendrobe [ 15 , 16 ], like high-performance liquid chromatography (HPLC) and HPLC-mass spectrum (HPLC-MS), which can provide a large amount of chemical composition information for the identification of dendrobe origin [ 17 – 21 ]. DNA molecular labeling and chromatography have the advantages of reproducibility, high separation efficiency, and high sensitivity, but they have high technical requirements, expensive analysis costs, and long analysis time.…”

Section: Introductionmentioning

confidence: 99%

Tracing the Geographical Origins of Dendrobe (Dendrobium spp.) by Near-Infrared Spectroscopy Sensor Combined with Porphyrin and Chemometrics

Kang

et al. 2020

Journal of Analytical Methods in Chemistry

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Dendrobe (Dendrobium spp.) is a traditional medicinal and edible food, which is rich in nutrients and contains biologically active metabolites. The quality and price of dendrobe are related to its geographical origins, and high quality dendrobe is often imitated by low quality dendrobe in the market. In this work, near-infrared (NIR) spectroscopy sensor combined with porphyrin and chemometrics was used to distinguish 360 dendrobe samples from twelve different geographical origins. Partial least squares discriminant analysis (PLSDA) was used to study the sensing performance of traditional NIR and tera-(4-methoxyphenyl)-porphyrin (TMPP)-NIR on the identification of dendrobe origin. In the PLSDA model, the recognition rate of the training and prediction set of the TMPP-NIR could reach 100%, which was higher than the 91.85% and 91.34% of traditional NIR. And the accuracy, sensitivity, and specificity of the TMPP-NIR sensor are all 1.00. The mechanism of TMPP improving the specificity of NIR spectroscopy should be related to the π-π conjugated system and the methoxy groups of TMPP interact with the chemical components of dendrobe. This study reflected that NIR spectrum with TMPP sensor was an effective approach for identifying the geographic origin of dendrobe.

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Characterization of plant polysaccharides from Dendrobium officinale by multiple chromatographic and mass spectrometric techniques

Cited by 38 publications

References 41 publications

Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO‐1 pathway

Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO‐1 pathway

Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review

Tracing the Geographical Origins of Dendrobe (Dendrobium spp.) by Near-Infrared Spectroscopy Sensor Combined with Porphyrin and Chemometrics

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