Characterization of piroxicam crystal modifications

Vrečer, Franc; Vrbinc, Miha; Meden, Anton

doi:10.1016/s0378-5173(03)00057-7

Cited by 180 publications

(204 citation statements)

References 9 publications

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“…However, when PXC was maintained in aqueous medium for 24 h a peak at 122 °C, corresponding to dehydratation, was observed, indicating the presence of PXC in the monohydrate form, in agreement with the X-ray diffraction analysis and data from different polymorphic forms of piroxicam described in the literature. 12 This peak can be observed in the DSC curve of the microparticles prepared using M2 conditions. One interesting point that can be evaluated from the DSC curves for the microparticles prepared using the two conditions is the enthalpy of fusion value ( H f = 91 J g -1 ) which corresponds to the sum of the enthalpy of fusion values for the undiluted components, considering the percentage in the microparticle composition.…”

Section: Thermal Analysis and X-ray Powder Diffraction Analysismentioning

confidence: 88%

“…12 After the microencapsulation of the drug in the polymeric matrix, peaks corresponding to PHB at 2 of 13.5° and 16.9° and peaks of PXC were observed in the X-ray pattern of microparticles prepared through the conditions of M2 and M7 ( Figures 2C and 2D), indicating that both components of the microparticle are in a crystalline form. Figure 3 shows the DSC curves for PHB, piroxicam and polymer/drug microparticles obtained using the conditions of M2 and M7.…”

Section: Thermal Analysis and X-ray Powder Diffraction Analysismentioning

confidence: 97%

“…Also, the fast rate of PHB crystallization may contribute to the formation of a rough and porous polymeric matrix. [11][12][13] After the release of the drug, the morphology of the microparticles had the same characteristics (visualized by SEM; micrographs not shown), the molecular weight of PHB remained unchanged and pores sizes between 40 and 100 Å appear, as shown in Figure 5 (B and D), suggesting that the drug release occurred mainly through the desorption of the PXC from the microparticle surfaces (in the case of M2) and its diffusion through the matrix pores formed during the preparation of the particles and also the pores formed due to the drug solubilization in the dissolution medium (in the case of M7).…”

Section: In Vitro Drug Releasementioning

confidence: 99%

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Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam

Bazzo¹,

Lemos‐Senna²,

Gonçalves³

et al. 2008

J. Braz. Chem. Soc.

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No presente estudo foram preparadas micropartículas de poli(hidroxibutirato) contendo piroxicam pela técnica de emulsão-evaporação do solvente. A influência de alguns parâmetros do processo sobre a eficiência de encapsulação do fármaco foi avaliada por meio de um planejamento fatorial do tipo 2 3 . A eficiência de encapsulação do piroxicam variou de 5,5 a 89,8%. Micropartículas ocas e irregulares, contendo cristais de fármaco na superfície, foram obtidas quando se utilizou 5 mL de clorofórmio como fase interna da emulsão. Com o ensaio de liberação in vitro evidenciouse que, após 8 h, todo o fármaco havia sido liberado para o meio. Micropartículas esféricas com superfície externa rugosa e porosa foram obtidas quando se utilizou 20 mL de diclorometano como fase interna e adicionou-se isopropanol à fase externa da emulsão. Essas microesferas foram capazes de controlar a liberação do piroxicam durante 50 h. Os resultados obtidos demonstraram que é possível obter micropartículas com características específicas pela otimização das condições empregadas no processo de encapsulação.In this study, poly(hydroxybutyrate) microparticles containing piroxicam were prepared by the oil-in-water emulsion-solvent evaporation method. The effects of some process conditions on drug content were determined using a 2 3 factorial design. The piroxicam loading efficiency varied from 5.5 to 89.8 %. Hollow and irregular microparticles with drug crystals on their surfaces were obtained when 5 mL of chloroform was used as the internal phase. In the release study, all of the piroxicam was released to the dissolution medium (phosphate buffer pH 7.4) after 8 h. Small spherical microspheres with a rough and porous polymeric matrix were obtained when 20 mL of dichloromethane was used as the internal phase and isopropanol was added to the external aqueous phase. These microspheres controlled the piroxicam release for approximately 50 h. The results demonstrated that it is possible to obtain microparticles with specific characteristics by the optimization of the process conditions.

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Section: Thermal Analysis and X-ray Powder Diffraction Analysismentioning

confidence: 88%

Section: Thermal Analysis and X-ray Powder Diffraction Analysismentioning

confidence: 97%

Section: In Vitro Drug Releasementioning

confidence: 99%

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Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam

Bazzo¹,

Lemos‐Senna²,

Gonçalves³

et al. 2008

J. Braz. Chem. Soc.

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“…The spray drying process yielded spherical particles of around 2.5 µm but showed some agglomeration in Sample A, B and C with sample B showing some of the needle-like characteristics of PXM form II [62]. The needle form of PXM may have contributed to the poor dissolution of sample B as it has been reported that the form II PXM polymorph is less soluble than the Form I polymorph [63]. However, this was in contrast to the observations by other researchers who report an increase in solubility with the Form II polymorph [64,65].…”

Section: Resultsmentioning

confidence: 95%

“…However after spray drying, the DSC scan of spray-dried PXM exhibited two peaks; one at 196.47 ˚C and the other at 199.72˚C. This may be due to the fact that the spray drying process led to the re-crystallization of some PXM molecules in the Form II (lower melting point) polymorph of PXM [63]. This observation can be confirmed in the SEM image of spray-dried PXM (Supplementary materials figure 1) as needle-shaped PXM particles that are characteristic of Form II PXM were also observed [68].…”

Section: Resultsmentioning

confidence: 99%

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

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Thermodynamics and Relative Solubility Prediction of Polymorphic Systems

Abramov

Pencheva

2010

Chemical Engineering in the Pharmaceutical Industry

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Characterization of piroxicam crystal modifications

Cited by 180 publications

References 9 publications

Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam

Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Thermodynamics and Relative Solubility Prediction of Polymorphic Systems

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