Characterization of pioglitazone cyclodextrin complexes: Molecular modeling to in vivo evaluation

Bramhane, D. M.; Kulkarni, Preethi A; Martis, Elvis A. F.; Pissurlenkar, Raghuvir R. S.; Coutinho, Evans C.; Nagarsenker, Mangal S.

doi:10.4103/0975-7406.171680

Cited by 12 publications

(2 citation statements)

References 38 publications

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“…The slope was less than one i.e. 0.08483 lead to conclusion of formation of 1:1 stoichiometry for complextion of drug with HPBCD (33). The apparent stability constant for the drug-HPBCD complexation was found to be 73.94 per Mole.…”

Section: Phase Solubility Studymentioning

confidence: 93%

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Functionality Advancement of Poorly Soluble Drug by Comparative Study of Solubilizing Techniques with Molecular Simulation to in vivo evaluation

Mogal¹,

Derle²

2017

IJPTR

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:This study aimed at the functionality advancement of poorly soluble model drug i.e. Cefixime with HPBCD using comparative study of different solubility enhancement methods. CFX formulations with hydroxypropyl-β-cyclodextrin (HP-β-CD) prepared by different solubility enhancement methods viz.,physical mixture, kneading method, solvent evaporation, spray drying, lyophilization/freeze drying, microwave irradiation method and compared their solubility enhancement as well as dissolution. The optimized complexes characterized using ATR, 1H-NMR, ROSEY, XRD, SEM and DSC for confirming the complexation. In-vivo pharmacokinetic studies were performed using male wister rats (N=6) through oral route. Hydroxy propyl Beta cyclodextrin inclusion complexation prepared by spray drying method was found to be optimized for complexation with cefixime. Spray drying method was found to be better than other complexation techniques on basis of in-vitro dissolution studies. ATR, NMR, XRD, and DSC confirmed the formation of complex. The in silico anticipations for mode of incorporation were in agreeing with the experimental proton NMR measure. The bioavailability of cefixime was found to be enhanced more than3 times. In comparison to pure drug, statistically significant increase in the oral bioavailability was obtained with the HP-β-CD inclusion complex which was prepared by spray drying technique, with 347% increase in terms of Cmax. This comparative study gave idea about best suited method for solubility enhancement along with molecular docking and NMR studies for anticipating mode of inclusion & thus, ultimately, improving the oral bioavailability of CFX.

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Section: Phase Solubility Studymentioning

confidence: 93%

“…The three-dimensional structure for BCD was downloaded from Protein Data Bank (PDB ID: 3CGT) and HPBCD was worked by including 2-hydroxypropyl group at suitable places of BCD (33). Every one of the structures was minimized energetically in Schrodinger Suite 2012 (Schrödinger, USA).…”

Section: Structure Readinessmentioning

confidence: 99%

Functionality Advancement of Poorly Soluble Drug by Comparative Study of Solubilizing Techniques with Molecular Simulation to in vivo evaluation

Mogal¹,

Derle²

2017

IJPTR

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Molecularly Imprinted Potentiometric Sensor for Nanomolar Determination of Pioglitazone Hydrochloride in Pharmaceutical Formulations

2021

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Pioglitazone Hydrochloride (PG) is an insulin‐sensitizing drug and is indicated for the treatment of type II diabetes. In this study, newly molecularly imprinted electrochemical sensors were constructed for the potentiometric determination of PG in the pharmaceutical formulations (Diabetonorm® 45 and 15 mg) with high accuracy and precision. The MIP particles (ionophore) were prepared by using the PG drug as a template, acrylamide (AC) or methacrylic acid (MAA) as a functional monomer, and ethylene glycol dimthacrylate (EGDMA) as a cross‐linker. The best MIP was synthesized from AC as a functional monomer, AC‐MIP. The best sensor (CPEs) was formulated from graphite (47 wt%) as a carbon source, AC‐MIP (5 wt.%) as an ionophore, PMA (1 wt%) as an ion‐exchanger, DNPOE (47 wt.%) as a conductive oil so‐called plasticizer. The best CPE electrode exhibited response slope to the Nernstian slope of 63.0 mV Decade−1, linear dynamic range of 10−8–10−4 M with the detection limit of 1.0×10−8 M, along with high reversibility, short response time 30 sec, and a long lifetime. The constructed biosensors showed high selectivity against similar interfering species (e. g. arabinose, galactose, lactose, maltose, glucose, Ba2+, Cu2+, Na+, Zn2+, Mg2+, Fe2+, Ca2+, NH4+).

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Cyclodextrin-encapsulated new drug with promising anti-Trypanosoma cruzi activity

Zanetti,

do Nascimento Oliveira,

de Azevedo Maia

et al. 2023

J Therm Anal Calorim

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Characterization of pioglitazone cyclodextrin complexes: Molecular modeling to in vivo evaluation

Cited by 12 publications

References 38 publications

Functionality Advancement of Poorly Soluble Drug by Comparative Study of Solubilizing Techniques with Molecular Simulation to in vivo evaluation

Functionality Advancement of Poorly Soluble Drug by Comparative Study of Solubilizing Techniques with Molecular Simulation to in vivo evaluation

Molecularly Imprinted Potentiometric Sensor for Nanomolar Determination of Pioglitazone Hydrochloride in Pharmaceutical Formulations

Cyclodextrin-encapsulated new drug with promising anti-Trypanosoma cruzi activity

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