Characterization of Physiologic 18f-FDG Uptake With Pet-Ct in Dogs

Abstract

We evaluated the whole body distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) in seven beagle dogs using positron emission tomography/computed tomography. The mean and maximum standard uptake values (SUV) for various tissues were computed. The SUV of the aortic blood pool was 0.65 +/- 0.19. Moderate uptake was present in brain (3.40 +/- 1.01). Mild uptake was present in orbital muscles, soft palate, laryngeal and pharyngeal region, mandibular salivary gland, myocardium, liver, pancreas, kidney, and intestine. 18F-FDG uptake would be normally higher in these tissues because of normal physiologic activity. Mean and maximum SUV values of the eye, skeletal muscle, bone tissue, spleen, adrenal gland, stomach, tongue, gall bladder, and lung were similar to or lower than that of the aortic blood pool. These data provide a normal baseline for comparing pathologic 18F-FDG uptake.

Comparative Oncology: Evaluation of 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) for the Staging of Dogs with Malignant Tumors

“…In addition, in every patient, the SUV values of selected organs, the main target areas of metastases (lung, liver and spleen), and the lymph nodes as well as the primary tumors were measured individually (Table 4). These SUVs are in accordance with previously published FDG PET/CT data in dogs [9,13,15]. Furthermore the SUV in the primary tumors was increased compared to the physiologic thoracic and abdominal organs (Table 4).…”

“…Increased FDG uptake was present in both the primary tumors and in metastatic lesions [11]. Whole body PET/CT was performed in healthy dogs to evaluate the physiologic distribution of FDG in thoracic and abdominal organs, including liver, spleen, adrenal glands and heart muscle [13,18]. These data provide a basis for the interpretation of pathologic changes that can be imaged by using this technique.…”

Distribution of 2-deoxy-2-fluoro-d-glucose in the coelom of healthy bald eagles (Haliaeetus leucocephalus)

“…Hepatic activity was less than that described in humans and slightly higher than that reported in cats 2 ; in comparison with dogs, 3,4 liver activity in the eagles was either slightly higher or slightly lower than reported values. The exact reason for this was unclear, considering that GLUT-1 and GLUT-2 have been identified in the liver of avian species (chickens), and the avian liver contributes substantially to circulating blood glucose concentration.…”

“…1 The SUV is often used in PET imaging to provide a semiquantitative measurement of radiotracer accumulation in a specific tissue or ROI, allowing monitoring of changes in tissue uptake over time. In veterinary species, PET studies establishing the 18 FDG distribution in healthy animals have been performed in cats, 2 dogs, 3,4 and Hispaniolan Amazon parrots (Amazona ventralis). 5 Presently, PET scanners are becoming increasingly accessible to veterinarians; therefore, an understanding of the distribution of 18 FDG in healthy birds is necessary for accurate assessment of inflammatory and neoplastic diseases in avian species.…”

Standardised uptake values of 2-deoxy-2-[¹⁸F]fluoro-d-glucose using PET/CT in normal cats

“…The lung showed the lowest SUV compared with the other organs, which is consistent with the observation that 18 F-FDG does not accumulate in normal lung tissue. However, if lung cancer is present, the SUV will increase due to tumour metabolism (Vansteenkiste et al 1999;Weber et al 2000;Lee et al 2010).…”