Characterization of perineural invasion in different histological grades and variants of oral squamous cell carcinoma

Deepthi, G; Shyam, Ndvn; Kumar, G Kiran; Narayen, Vaishali; Paremala, K; Preethi, P.

doi:10.4103/jomfp.jomfp_162_19

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…About perineural invasion, PDSCC showed the highest percentage, which correlated with [ 31 ], who found that perineural and lymphovascular invasion were correlated with advanced histological grade. In addition [ 32 ], found that 70% of cases with perineural invasion were PDSCC, which means that the higher the grade, the more perineural or perivascular invasion will be found.…”

Section: Discussionmentioning

confidence: 99%

Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study

Mahmoud,

Abdellatif,

Mahmoud

2024

Head and Neck Pathol

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Purpose The aim of the study is to investigate the immunohistochemical expression of both Alpha smooth muscle actin and Transforming Growth Factor beta and compare their expression in oral papillary squamous cell carcinoma with their expression in different histological grades of oral squamous cell carcinoma. A correlation between these immuno-histochemical expressions and histological findings will then be performed. The research question is “Do the percentages of α-SMA and TGF-β immune-expression in OPSCC differ from that in the conventional OSCC?”. Methods This will be achieved by collecting archival blocks of oral papillary squamous cell carcinoma and different grades of oral squamous cell carcinoma, staining the specimens with Transforming Growth Factor beta and alpha smooth muscle actin, then measuring the mean staining index of expression in each group and the area percent of both markers. Results Results revealed that transforming growth factor beta expression in the epithelium was high in all cases of well-differentiated squamous cell carcinoma, most oral papillary squamous cell carcinoma, and poorly differentiated oral squamous cell carcinoma. On the other hand, different grades of oral squamous cell carcinoma showed a high staining index of alpha smooth muscle actin expression in the stroma. While cases of oral papillary squamous cell carcinoma were either moderate or low-staining. Conclusions Oral papillary squamous cell carcinoma has a favourable prognosis compared to different histological grades, and the prognosis does not depend only on histological grade but also on other prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study

Mahmoud,

Abdellatif,

Mahmoud

2024

Head and Neck Pathol

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Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Zheng

Wang³

2020

J Biochem & Molecular Tox

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Buccal mucosa carcinoma is a significant cause of death in developing nations. Vicenin‐2 is a significant bioactive compound found in Ocimum sanctum Linn or Tulsi that possesses several pharmacologic properties. Our focus is to understand the possible impact of Vicenin‐2 on 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced oral carcinogenesis in hamsters. Buccal carcinoma was induced by treatment with carcinogenic DMBA, three times a week for 14 weeks. We determined 100% tumor incidence, abnormal tumor volume, inclined tumor burden, and deduced body weight in DMBA‐induced oral squamous cell carcinoma (OSCC) hamsters. The upregulation of cytokine levels (interleukin [IL]‐6, IL‐1β, and tumor necrosis factor‐alpha [TNF‐α]) was observed in DMBA‐induced OSCC hamsters. Moreover, dysplastic, hyperplastic, and squamous cell carcinoma was identified in the DMBA‐induced OSCC hamsters. The diminished activities of lipid peroxidation and enzymatic/nonenzymatic antioxidants were observed in DMBA‐induced hamsters. Furthermore, the high expression of proliferating cell nuclear antigen (PCNA), Cyclin‐D1, and Bcl‐2, and attenuated Bax expression were observed in DMBA‐induced hamsters. Our study results explored that Vicenin‐2 (30 mg/kg) treated with DMBA‐brushed hamsters averted tumor incidence, improved the antioxidant status, and inhibited lipid peroxidation. Moreover, Vicenin‐2 inhibited the immunohistochemical expression of PCNA, Cyclin‐D1, and Bcl‐2, and significantly restored apoptotic Bax levels. The Vicenin‐2 treatment prevents the lesion formation in the oral epithelium of the DMBA‐induced hamsters. The Vicenin‐2 treatment potentially halts the proinflammatory cytokines (IL‐6, IL‐1β, and TNF‐α) production in OSCC hamsters. Thus, we proved that Vicenin‐2 prevents DMBA‐induced buccal carcinogenesis in hamsters via improving antioxidants by modulating apoptotic and cytokines signaling pathways.

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Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers

Pandit

Patil

Palwe

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Characterization of perineural invasion in different histological grades and variants of oral squamous cell carcinoma

Cited by 9 publications

References 25 publications

Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study

Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study

Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers

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