Characterization of Pentaclethra macroloba oil

Costa, Marina Nídia Ferreira dos Santos; Muniz, Marcos Antônio Pena; Negrão, Charles Alberto Brito; Costa, Carlos Emmerson Ferreira da; Lamarão, Maria Louze Nobre; Morais, Luiz Roberto Barbosa; Júnior, José Otávio Carréra Silva; Ribeiro-Costa, Roseane Maria

doi:10.1007/s10973-012-2896-z

Cited by 37 publications

(31 citation statements)

References 20 publications

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“…The spectra are presented in Figure 9 and it appears clear that the FT-IR spectra of Ucuùba fat, Capryol™ 90 and NLC samples presented striking similarities and were almost superimposable. In these spectra, the high intensity peak at 1745 cm −1 corresponds to the vibration of carbonyl groups [33]. The vibration of the C–O bond of the ester bonds present in triacylglycerols is related to the sequence of peaks identified at 1232, 1165, 1118 and 1097 cm −1 [35].…”

Section: Resultsmentioning

confidence: 99%

“…The absorption spectra of the excipients, i.e., Capryol™ 90, Ucuùba fat and ketoconazole, and NLC formulations, were analyzed using a Shimadzu spectrophotometer (IR Prestige 21, Kyoto, Japan) in the range 4000–1000 cm −1 . The samples were dripped in tablets of potassium bromide and spectra recorded using 32 scans and 2 cm −1 resolution at room temperature [33].…”

Section: Methodsmentioning

confidence: 99%

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Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design

et al. 2019

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Ucuùba fat is fat obtained from a plant found in South America, mainly in Amazonian Brazil. Due to its biocompatibility and bioactivity, Ucuùba fat was used for the production of ketoconazole-loaded nanostructured lipid carriers (NLC) in view of an application for the treatment of onychomycosis and other persistent fungal infections. The development and optimization of Ucuùba fat-based NLC were performed using a Box-Behnken design of experiments. The independent variables were surfactant concentration (% w/v), liquid lipids concentration (% w/v), solid lipids concentration (% w/v), while the outputs of interest were particle size, polydispersity index (PDI) and drug encapsulation efficiency (EE). Ucuùba fat-based NLC were produced and the process was optimized by the development of a predictive mathematical model. Applying the model, two formulations with pre-determined particle size, i.e., 30 and 85 nm, were produced for further evaluation. The optimized formulations were characterized and showed particle size in agreement to the predicted value, i.e., 33.6 nm and 74.6 nm, respectively. The optimized formulations were also characterized using multiple techniques in order to investigate the solid state of drug and excipients (DSC and XRD), particle morphology (TEM), drug release and interactions between the formulation components (FTIR). Furthermore, particle size, surface charge and drug loading efficiency of the formulations were studied during a one-month stability study and did not show evidence of significant modification.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design

et al. 2019

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“…Its components are typically observed between 1590 and 1820 cm −1 or 3000 and 3400 cm −1 , which are characteristic of OH vibrational stretching [31, 32]. Moreover, less intense peaks were observed at 775 and 820 cm −1 (benzene ring vibrations) [30], 1044 cm −1 (C–H) [33], 1099 cm −1 (C–O–C) [34], 1197–1280 cm −1 (C–O) [35], 1438 cm −1 (C–O–H) [36], and 1517 cm −1 (C=C) [37]. The same spectral profile was observed for the AuNPs, suggesting that the V. oleifera resin was linked with the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Monodisperse Gold Nanocrystals Using Virola oleifera

et al. 2016

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The development of new routes and strategies for nanotechnology applications that only employ green synthesis has inspired investigators to devise natural systems. Among these systems, the synthesis of gold nanoparticles using plant extracts has been actively developed as an alternative, efficient, cost-effective, and environmentally safe method for producing nanoparticles, and this approach is also suitable for large-scale synthesis. This study reports reproducible and completely natural gold nanocrystals that were synthesized using Virola oleifera extract. V. oleifera resin is rich in epicatechin, ferulic acid, gallic acid, and flavonoids (i.e., quercetin and eriodictyol). These gold nanoparticles play three roles. First, these nanoparticles exhibit remarkable stability based on their zeta potential. Second, these nanoparticles are functionalized with flavonoids, and third, an efficient, economical, and environmentally friendly mechanism can be employed to produce green nanoparticles with organic compounds on the surface. Our model is capable of reducing the resin of V. oleifera, which creates stability and opens a new avenue for biological applications. This method does not require painstaking conditions or hazardous agents and is a rapid, efficient, and green approach for the fabrication of monodisperse gold nanoparticles. Graphical AbstractThe Virola oleifera reduction method for the synthesis of gold nanoparticles (AuNP’s)

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“…Thermogravimetric (TG) analysis was performed on a TGA-50/50H analyzer (Shimadzu, Kyoto, Japan) in the temperature range from 25-600 • C, using platinum crucibles containing approximately 3 mg of samples, under a dynamic nitrogen atmosphere (50 mL•min −1 ) and heating rate of 10 • C•min −1 . To obtain the TG/DTG profiles, the equipment was calibrated with calcium oxalate monohydrate, according to Santos Costa et al [59].…”

Section: Physicochemical Characterization Of Inclusion Complexesmentioning

confidence: 99%

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

Magalhães

Macedo

Pacheco

et al. 2020

IJMS

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The development of inclusion complexes is used to encapsulate nonpolar compounds and improve their physicochemical characteristics. This study aims to develop complexes made up of Euterpe oleracea Mart oil (EOO) and β-cyclodextrin (β-CD) or hydroxypropyl-β-cyclodextrin (HP-β-CD) by either kneading (KND) or slurry (SL). Complexes were analyzed by molecular modeling, Fourier-transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction, thermogravimetry analysis and differential scanning calorimetry. The antibacterial activity was expressed as Minimum Inhibitory Concentration (MIC), and the antibiotic resistance modulatory activity as subinhibitory concentration (MIC/8) against Escherichia coli, Streptomyces aureus, Pseudomonas aeruginosa and Enterococcus faecalis. Inclusion complexes with β-CD and HP-β-CD were confirmed, and efficiency was proven by an interaction energy between oleic acid and β-CD of −41.28 ± 0.57 kJ/mol. MIC values revealed higher antibacterial activity of complexes compared to the isolated oil. The modulatory response of EOO and EOO-β-CD prepared by KND as well as of EOO-β-CD and EOO-HP-β-CD prepared by SL showed a synergistic effect with ampicillin against E. coli, whereas it was not significant with the other drugs tested, maintaining the biological response of antibiotics. The antimicrobial response exhibited by the complexes is of great significance because it subsidizes studies for the development of new pharmaceutical forms.

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Characterization of Pentaclethra macroloba oil

Cited by 37 publications

References 20 publications

Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design

Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design

Facile Synthesis of Monodisperse Gold Nanocrystals Using Virola oleifera

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

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