Characterization of PEG in monomethyl ethers of PEG by 2‐D LC

Abstract

PEGs present in samples of the corresponding monomethyl ethers are analyzed by 2-D LC with LC at critical conditions as the first and liquid adsorption chromatography as the second dimension. The fractions from the first dimension are transferred to the second one by heart-cutting using a ten-port valve. The efficiency of the separation is dramatically improved by adding water to the eluate from the first dimension before the switching valve in order to have a weaker eluent in the fraction than that of the second dimension. By this procedure, the fractions are focussed and reconcentrated. The molar mass distribution of the PEG fraction can be determined with good accuracy even at very low amounts of PEG in the PEG-monomethyl ethers (down to 0.5%).

Gas chromatography with mass spectrometry for the quantification of ethylene glycol ethers in different household cleaning products

“…Humans are exposed to glycol ethers because of their wide use in industry and households as solvents, detergents, or emulsifiers . The lipophilic and hydrophilic character of these compounds, induced by ether and alcohol groups, as well as their relatively high boiling point, is the reason for their large‐scale use.…”

“…The toxicity of ethylene glycol monomethyl ether (EGME), which causes reproductive, hematological, and developmental defects , promoted its removal from a great number of formulations in many countries . Nevertheless, EGME and diethylene glycol monomethyl ether (DEGME), the latter classified as harmful, are still used primarily as intermediates in processing solvents and as jet fuel deicing additives .…”

“…GC is the most widely used method for quantification of EGs, and as far as we know, only one application of LC is reported in the literature, involving derivatization of the analytes for fluorescence detection . Flame ionization detection and MS are used as the detection systems coupled to GC. Different types of samples, such as paints , fuels , biological fluids , air samples ,waters , and foods have been analyzed.…”

“…The analysis of water samples for EG quantification has also been carried out using headspace sampling . Headspace solvent microextraction with benzyl alcohol was seen to effectively preconcentrate EGBE from aqueous solutions .…”

Kinetic Optimization of Folic Acid Polymer Conjugates for Drug Targeting

“…The ability to incorporate charged species into the polymer also needs hydrosolubility property (Pathak et al, 2007). In addition, the application of Poly(Ethylene Oxide) (PEO) in the therapeutic polymer field has rose tremedously, owing to its numerous properties of solubility in both aqueous and organic media, as well as ease of chemical modification and biocompatibility (Stella et al, 2000;Ahmed and Trathnigg, 2010). Currently Ngoy et al (2011) found that folic acid bound conjugate to multi walled carbon nanotubes (MWCNTs) had a high hydrophilicity property over conventional conjugates.…”