Characterization of PDL1 enhanced siRNA/albumin liposome for effective therapeutic function in lung cancer

Zhang, Liming; Xie, Guangke; Xiao, Xin; Cheng, Chao

doi:10.1007/s00432-022-04298-2

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…The fabrication process is complicated and expensive, which restricts accessibility. Liposomes’ efficacy in targeting tumors is hindered by the variability of tumor blood vessels and quick removal from the bloodstream by the mononuclear phagocyte system, which reduces drug delivery to the tumor site [ 10 ]. Cancer cells can develop resistance mechanisms against medications, which can impact the effectiveness of treatment [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Hamad,

Harb,

Bustanji

2024

Pharmaceutics

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Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role in drug delivery. With their amphiphilic design, liposomes efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise in advancing cancer therapy methodologies. Bibliometric research analyzes systematic literary data statistically. This study used bibliometric indicators to examine, map, and evaluate the applications of liposomes in cancer therapy. A Scopus search was conducted to identify all English-language peer-reviewed scientific publications on the applications of liposomes in cancer therapy within the past twenty years. Bibliometric indicators were calculated using VOSviewer and Biblioshiny. We produced thematic, conceptual, and visualization charts. A total of 14,873 published documents were obtained. The procedure of keyword mapping has effectively identified the main areas of research concentration and prevailing trends within this specific field of study. The significant clusters discovered through theme and hotspot analyses encompassed many topics such as the use of multiple strategies in chemotherapy and different forms of cancer, the study of pharmacokinetics and nanomedicine, as well as the investigation of targeted drug delivery, cytotoxicity, and gene delivery. Liposomes were employed as drug delivery systems so as to selectively target cancer cells and improve the bioavailability of anticancer drugs. The work showcased the capacity to tailor these liposomes for accurate drug delivery by including potent anticancer medications. Our findings not only bring attention to the latest progress in utilizing liposomes for cancer treatment but also underscore the vital need for ongoing research, collaborative efforts, and the effective translation of these breakthroughs into tangible clinical applications, emphasizing the dynamic and evolving nature of cancer therapeutics.

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Section: Introductionmentioning

confidence: 99%