Characterization of Patients With Axial Spondyloarthritis by Enthesitis Presence: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry

Abstract

Objective. To compare the characteristics of patients with axial spondyloarthritis (axSpA) who had enthesitis versus those without enthesitis. Methods. This study included adult patients with axSpA enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry (March 2013 to August 2018). Enthesitis was assessed at enrollment via the Spondyloarthritis Research Consortium of Canada Enthesitis Index. Characteristics were compared between patients with and without enthesitis using t tests or Wilcoxon rank-sum tests for continuous variables and χ 2 or Fisher exact tests for categorical variables. Results. Of 477 patients with axSpA, 121 (25.4%) had enthesitis (mean, 3.9 sites) at enrollment. Higher proportions of patients with enthesitis were female and had nonradiographic axSpA than those without enthesitis (both P < 0.05). Additionally, higher proportions of patients with enthesitis had prior biologic (38.8% vs 27.2%) and conventional synthetic disease-modifying antirheumatic drug (csDMARD; 24.8% vs 13.3%) use and were currently receiving a combination of biologics and csDMARDs (28.6% vs 18.1%) than those without enthesitis. Patients with enthesitis had worse disease activity (tender and swollen joint counts, physician global assessment, Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Disease Activity Index, and Bath Ankylosing Spondylitis Functional Index), spinal mobility, and quality of life (pain, fatigue, Health Assessment Questionnaire, and EuroQol visual analog scale scores); greater work impairment; and had a history of depression and fibromyalgia than those without enthesitis (all P < 0.05). Conclusion. In this US-based real-world study, enthesitis in patients with axSpA was associated with worse disease activity and quality of life than those with no enthesitis.

Rheumatic manifestations of Chikungunya virus infection: Prevalence, patterns, and enthesitis

“…Highly active CHIKV-related disease was associated with enthesitis, similar to that found in psoriatic arthritis [62]. Enthesitis might be a sign of increased burden as it is associated with disease severity and poor function, which is consistent with that seen in SpA patients who also have enthesitis [63]. One study reported that the presence of at least one site of enthesitis increased the risk of developing chronic CHIKV-related arthritis [5].…”

Клиническое Значение Энтезитов При Спондилоартритах: От Патофизиологии К Лечению (Обзор Литературы)

“…Лекції, огляди / Lectures, Reviews activity, higher pain indices and a compromised life quality [9]. The enthesitis is a common PsA symptom; the PsA patients are four times as likely to be presenting entheses' lesions at the ultrasound examination as the ankylosing spondylitis patients [10].…”

“…The enthesitis observed in the PsA patients may attend the axial and peripheral joint injuries; there is a high likelihood of ankylozation, the overall higher disease activity, pain intensity, more compromised life quality and functional state, sleep disorders and more intense fatigue reported by the patients [13,14]. Furthermore, the PsA-attended enthesitis is con-sidered a harbinger of negative disease outcomes and may forecast a smaller likelihood of remission and low disease activity [9,15]. At the moment, the entheses are referred to as a key inflammation target with such musculoskeletal diseases as PsA and spondyloarthritis [6].…”

Diagnóstico diferencial das entesopatias. Parte 2 – Entesopatias de causas inflamatórias

“…As entesites são mais frequentes entre pacientes do sexo feminino versus sexo masculino [11][12][13][14] . As prevalências reportadas variam entre 34-74% e 35% em pacientes com EA e EpA não radiográfica, respectivamente [15][16][17] .…”