Characterization of pathological changes in the olfactory system of mice exposed to methylmercury
Yuta Iijima,
Ryohei Miki,
Nobumasa Takasugi
et al.
Abstract:Methylmercury (MeHg) is a well-known environmental neurotoxicant that causes severe brain disorders such as Minamata disease. Although some patients with Minamata disease develop olfactory dysfunction, the underlying pathomechanism is largely unknown. We examined the effects of MeHg on the olfactory system using a model of MeHg poisoning in which mice were administered 30 ppm MeHg in drinking water for 8 weeks. Mice exposed to MeHg displayed significant mercury accumulation in the olfactory pathway, including … Show more
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