Characterization of particle deposition in a lung model using an individual path

Tena, A.M.; Casán, Pere; Pastor, Joaquı́n; Ferrera, C.; Marcos, Alfonso

doi:10.1051/epjconf/20134501079

Cited by 9 publications

(15 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, in silico studies addressed to respiratory lung modeling have been covering detailed patient-specific 3D lung reconstruction [13,14], nasopharynx-trachea ventilation features [6,7,15], 3D-1D coupling of upper and middle airway segments, and FSI simulations [16]. The lumped models operate with lung mechanics in terms of tidal volume and pressure with lower details [17,18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

et al. 2017

View full text Add to dashboard Cite

An airflow in the first four generations of the tracheobronchial tree was simulated by the 1D model of incompressible fluid flow through the network of the elastic tubes coupled with 0D models of lumped alveolar components, which aggregates parts of the alveolar volume and smaller airways, extended with convective transport model throughout the lung and alveolar components which were combined with the model of oxygen and carbon dioxide transport between the alveolar volume and the averaged blood compartment during pathological respiratory conditions. The novel features of this work are 1D reconstruction of the tracheobronchial tree structure on the basis of 3D segmentation of the computed tomography (CT) data; 1D−0D coupling of the models of 1D bronchial tube and 0D alveolar components; and the alveolar gas exchange model. The results of our simulations include mechanical ventilation, breathing patterns of severely ill patients with the cluster (Biot) and periodic (Cheyne-Stokes) respirations and bronchial asthma attack. The suitability of the proposed mathematical model was validated. Carbon dioxide elimination efficiency was analyzed in all these cases. In the future, these results might be integrated into research and practical studies aimed to design cyberbiological systems for remote real-time monitoring, classification, prediction of breathing patterns and alveolar gas exchange for patients with breathing problems.

show abstract

Section: Discussionmentioning

confidence: 99%

“…where V n p is an element of discrete function which is defined on the mesh and represents mesh analog for the V from Equation (15). This mesh is uniform along the x axis:…”

Section: Numerical Implementationmentioning

confidence: 99%

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The resultant graph of the bronchial tree contains up to seven generations. Two torus configurations were used to design an individual bifurcation in [7][8][9] (Fig. 4).…”

Section: Introductionmentioning

confidence: 99%

Analytical Design of the Human Bronchial Tree for Healthy Patients and Patients with Obstructive Pulmonary Diseases

Медведев¹,

Gafurova²

2019

Math.Biol.Bioinf.

View full text Add to dashboard Cite

The study is aimed at the analytical design of the full human bronchial tree for healthy patients and patients with obstructive pulmonary diseases. Analytical formulas for design of the full bronchial tree are derived. All surfaces of the bronchial tree are matched with the second-order smoothness (there are no acute angles or ribs). The geometric characteristics of the human bronchial tree in the pathological case are modeled by a "starry" shape of the inner structure of the bronchus; the pathology degree is defined by two parameters: bronchus constriction level and degree of distortion of the cylindrical shape of the bronchus. Closed analytical formulas allow the human bronchial tree of an arbitrary complexity (up to alveoli) to be designed; moreover, the parametric dependences make it possible to specify any desirable degree of airway obstruction.

show abstract

“…Furthermore, the reduced geometry approach has been coupled with realistic, CT-scan-based computational geometries to provide realistic yet efficient CFD models for steady-state inhalation [17]. Recent studies have adopted the most limiting case of a reduced-geometry approach, in which a single flow path is modeled as a representative example of the flow through all investigated generations of airflow [18][19][20][21]. Figure 1 provides an illustration of the reduced-geometry approach, based on truncation of selected airway branches.…”

Section: Introductionmentioning

confidence: 99%

“…Among studies employing reduced-geometry models, five different approaches can be identified for specification of boundary conditions at truncated airway boundaries. These may be summarized as: specified pressure [23], specified mass flow rate [18][19][20][21]24], impedance modeling [25,26], 1D modeling of truncated branches [11,13], and stochastic coupling of interior and outlet zones [12,16,17]. The first two approaches are selfexplanatory.…”

Section: Introductionmentioning

confidence: 99%

Cyclic Breathing Simulations in Large Scale Models of the Lung Airway From the Oronasal Opening to the Terminal Bronchioles

Walters

Burgreen

Hester

et al. 2012

Volume 2: Biomedical and Biotechnology

View full text Add to dashboard Cite

Computational fluid dynamics (CFD) simulations were performed for unsteady periodic breathing conditions, using large-scale models of the human lung airway. The computational domain included fully coupled representations of the orotracheal region and large conducting zone up to generation four (G4) obtained from patient-specific CT data, and the small conducting zone (to G16) obtained from a stochastically generated airway tree with statistically realistic geometrical characteristics. A reduced-order geometry was used, in which several airway branches in each generation were truncated, and only select flow paths were retained to G16. The inlet and outlet flow boundaries corresponded to the oronasal opening (superior), the inlet/outlet planes in terminal bronchioles (distal), and the unresolved airway boundaries arising from the truncation procedure (intermediate). The cyclic flow was specified according to the predicted ventilation patterns for a healthy adult male at three different activity levels, supplied by the whole-body modeling software HumMod. The CFD simulations were performed using Ansys FLUENT. The mass flow distribution at the distal boundaries was prescribed using a previously documented methodology, in which the percentage of the total flow for each boundary was first determined from a steady-state simulation with an applied flow rate equal to the average during the inhalation phase of the breathing cycle. The distal pressure boundary conditions for the steady-state simulation were set using a stochastic coupling procedure to ensure physiologically realistic flow conditions. The results show that: 1) physiologically realistic flow is obtained in the model, in terms of cyclic mass conservation and approximately uniform pressure distribution in the distal airways; 2) the predicted alveolar pressure is in good agreement with previously documented values; and 3) the use of reduced-order geometry modeling allows accurate and efficient simulation of large-scale breathing lung flow, provided care is taken to use a physiologically realistic geometry and to properly address the unsteady boundary conditions.

show abstract

Characterization of particle deposition in a lung model using an individual path

Cited by 9 publications

References 5 publications

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

Analytical Design of the Human Bronchial Tree for Healthy Patients and Patients with Obstructive Pulmonary Diseases

Cyclic Breathing Simulations in Large Scale Models of the Lung Airway From the Oronasal Opening to the Terminal Bronchioles

Contact Info

Product

Resources

About