Characterization of pain-related behaviors, changes in bone microarchitecture and sensory innervation induced by chronic cadmium exposure in adult mice

Torres-Rodríguez, Héctor Fabián; Graniel-Amador, Mayra A.; Cruz-Camacho, Cindy J.; Cantú-Martínez, Alma A.; A, Martínez-Martínez; Petricevich, Vera L.; Montes, Sergio; Castañeda-Corral, Gabriela; Jiménez-Andrade, Juan Miguel

doi:10.1016/j.neuro.2022.01.009

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Potential Mechanism Of Cgrp In Modulating Osteoporosis1

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“…Electrical stimulation of DRG increased the expression of CGRP in DRG and healing bone tissue by promoting angiogenesis and osteogenesis via Ca(2+)/CaMKII/CREB signaling pathway ( Mi et al., 2022a ). In cadmium-treated mice, the deterioration of femoral trabecular microstructure, reduction of CGRP + nerve fibers, and mechanical hyperactivities were accompanied ( Torres-Rodríguez et al., 2022 ). In addition, the expression of CGRP in the femur was reduced while the expression of CGRP and serotonin in the spinal cord was increased by OVX ( Zhang et al., 2021c ).…”

Section: Potential Mechanism Of Cgrp In Modulating Osteoporosismentioning

confidence: 99%