Characterization of offensive responses during the maturation of play‐fighting into aggression in male golden hamsters

Cervantes, M. Catalina; Taravosh-Lahn, Kereshmeh; Wommack, Joel C.; Delville, Yvon

doi:10.1002/dev.20183

Cited by 18 publications

(25 citation statements)

References 23 publications

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“…Juvenile and adolescent males tend to display more overt aggressive behaviors towards their opponents, while adult males communicate dominance through posturing and an array of both aggressive and submissive behaviors [15, 21, 47-49]. In the second experiment, we found long term changes in agonistic behaviors (aggressive and submissive behaviors) due to AAS exposure during adolescence and adulthood.…”

Section: Discussionmentioning

confidence: 81%

Anabolic steroids have long-lasting effects on male social behaviors

Salas-Ramirez

Montalto

Sisk

2010

Behavioural Brain Research

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Anabolic androgenic steroids (AAS) use by adolescents is steadily increasing. Adolescence involves remodeling of steroid-sensitive neural circuits that mediate social behaviors, and previous studies using animal models document effects of AAS on male social behaviors. The present experiments tested whether AAS have persistent and more pronounced behavioral consequences when drug exposure occurs during adolescence as compared to exposure in adulthood. Male Syrian hamsters were injected daily for 14 days with either vehicle or an AAS cocktail containing testosterone cypionate (2 mg/kg), nandrolone decanoate (2 mg/kg), and boldenone undecylenate (1 mg/kg), either during adolescence (27-41 days of age) or adulthood (63-77 days of age). As adults, subjects were tested two or four weeks after the last injection for either sexual behavior with a receptive female or male-male agonistic behavior in a resident-intruder test. Compared with vehicle-treated males, AAStreated males, regardless of age of treatment, displayed fewer long intromissions and a significant increase in latency to the first long intromission, indicative of reduced potential to reach sexual satiety. Increased aggression was observed in males exposed to AAS compared with males treated with vehicle, independently of age of AAS treatment. However, unlike hamsters exposed to AAS in adulthood, hamsters exposed to AAS during adolescence did not display any submissive or riskassessment behaviors up to 4 weeks after discontinuation of AAS treatment. Thus, AAS have longlasting effects on male sexual and agonistic behaviors, with AAS exposure during adolescence resulting in a more pronounced reduction in submissive behavior compared to AAS exposure in adulthood.

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Section: Discussionmentioning

confidence: 81%

Anabolic steroids have long-lasting effects on male social behaviors

Salas-Ramirez

Montalto

Sisk

2010

Behavioural Brain Research

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“…It has been suggested that low levels of rough and tumble play may indicate vulnerability toward reduced motivated behavior in adulthood (Trezza et al, 2010). For example, animal models have demonstrated a relationship between rough and tumble play and future sexual and aggressive behaviors (van den Berg et al, 1999a; Cervantes et al, 2007; Wommack and Delville, 2007). Thus, decreased rough and tumble play in MOR-F1 males may suggest an increased risk for deficits in other motivated behavior in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Adolescent Opiate Exposure in the Female Rat Induces Subtle Alterations in Maternal Care and Transgenerational Effects on Play Behavior

Johnson¹,

Carini²,

Schenk³

et al. 2011

Front. Psychiatry

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The non-medical use of prescription opiates, such as Vicodin® and MSContin®, has increased dramatically over the past decade. Of particular concern is the rising popularity of these drugs in adolescent female populations. Use during this critical developmental period could have significant long-term consequences for both the female user as well as potential effects on her future offspring. To address this issue, we have begun modeling adolescent opiate exposure in female rats and have observed significant transgenerational effects despite the fact that all drugs are withdrawn several weeks prior to pregnancy. The purpose of the current set of studies was to determine whether adolescent morphine exposure modifies postpartum care. In addition, we also examined juvenile play behavior in both male and female offspring. The choice of the social play paradigm was based on previous findings demonstrating effects of both postpartum care and opioid activity on play behavior. The findings revealed subtle modifications in the maternal behavior of adolescent morphine-exposed females, primarily related to the amount of time females’ spend nursing and in non-nursing contact with their young. In addition, male offspring of adolescent morphine-exposed mothers (MOR-F1) demonstrate decreased rough and tumble play behaviors, with no significant differences in general social behaviors (i.e., social grooming and social exploration). Moreover, there was a tendency toward increased rough and tumble play in MOR-F1 females, demonstrating the sex-specific nature of these effects. Given the importance of the postpartum environment on neurodevelopment, it is possible that modifications in maternal–offspring interactions, related to a history of adolescent opiate exposure, plays a role in the observed transgenerational effects. Overall, these studies indicate that the long-term consequences of adolescent opiate exposure can impact both the female and her future offspring.

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“…On P43, play-deprived animals were re-housed with their play-exposed littermates. We targeted P21–P42 for play deprivation because this is the period of early puberty when rates of social play peak in hamsters (Cervantes, Taravosh-Lahn, Wommack, & Delville, 2007; Pellis & Pellis, 1988). …”

Section: Methodsmentioning

confidence: 99%

Social play in juvenile hamsters alters dendritic morphology in the medial prefrontal cortex and attenuates effects of social stress in adulthood.

Burleson¹,

Pedersen²,

Seddighi³

et al. 2016

Behavioral Neuroscience

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Social play is a fundamental aspect of behavioral development in many species. Social play deprivation in rats alters dendritic morphology in the ventromedial prefrontal cortex (vmPFC) and we have shown that this brain region regulates responses to social defeat stress in Syrian hamsters. In this study, we tested whether play deprivation during the juvenile period disrupts dendritic morphology in the prefrontal cortex and potentiates the effects of social defeat stress. At weaning, male hamsters were either group-housed with peers or pair-housed with their mother, with whom they do not play. In adulthood, animals received acute social defeat stress or no-defeat control treatment. The hamsters were then tested for a conditioned defeat response in a social interaction test with a novel intruder, and were also tested for social avoidance of a familiar opponent. Brains were collected for Golgi-Cox staining and analysis of dendritic morphology in the infralimbic (IL), prelimbic (PL), and orbitofrontal cortex (OFC). Play-deprived animals showed an increased conditioned defeat response and elevated avoidance of a familiar opponent compared to play-exposed animals. Also, play-deprived animals showed increased total length and branch points in apical dendrites of pyramidal neurons in the IL and PL cortices, but not in the OFC. These findings suggest that social play deprivation in juvenile hamsters disrupts neuronal development in the vmPFC and increases vulnerability to the effects of social stress in adulthood. Overall, these results suggest that social play is necessary for the natural dendritic pruning process during adolescence and promotes coping with stress in adulthood.

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Characterization of offensive responses during the maturation of play‐fighting into aggression in male golden hamsters

Cited by 18 publications

References 23 publications

Anabolic steroids have long-lasting effects on male social behaviors

Anabolic steroids have long-lasting effects on male social behaviors

Adolescent Opiate Exposure in the Female Rat Induces Subtle Alterations in Maternal Care and Transgenerational Effects on Play Behavior

Social play in juvenile hamsters alters dendritic morphology in the medial prefrontal cortex and attenuates effects of social stress in adulthood.

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