Characterization of novel soybean‐oil‐based thermosensitive amphiphilic polymers for drug delivery applications

Abstract

Hydrolyzed polymers of soybean oil (HPSO) and of epoxidized soybean oil (HPESO) were developed previously. Owing to their natural food origin and biocompatibility, we exploited further their potential as a drug delivery system and pharmaceutical excipients. This work aimed to investigate self-assembly, thermal transition, interaction with various drugs and surface activity of these novel amphiphilic polymers. The critical micelle concentration of HPSO and HPESO was determined by the surface tension method. The molecular interaction between HPESO and anticancer drug doxorubicin HCl was examined. The effect of the polymers on the solution contact angle and surface energy of compressed tablets of hydrophobic drugs ibuprofen and nifedipine was measured. The thermal transition temperatures T tr (cloud points) of the polymers in aqueous solutions increased with increasing polymer concentration. HPSO exhibited lower T tr than HPESO. The critical micelle concentration was found to be 0.05 mg mL −1 for HPSO and 0.08 mg mL −1 for HPESO. Strong molecular interactions between HPESO and doxorubicin were observed. Both polymers reduced the interfacial energy and contact angles of drug tablets with more effect on ibuprofen tablets with the use of HPSO. These results suggest that the novel soybean-oil-based amphiphilic polymers have great potential for drug delivery and pharmaceutical formulations.

Formation of liquid‐crystalline morphologies in dilute solutions of a charged random terpolymer

“…Self‐assembly is a very important phenomenon learned from nature with numerous biomedical and industrial applications. Various chemical or biochemical molecules such as lipids, synthetic peptides, nucleic acids, low‐molecular‐weight surfactants and block copolymers have been found to form self‐assembled structures .…”

A Review on Biodegradable Polymeric Materials Derived from Vegetable Oils for Diverse Applications

“…Due to natural origin and biocompatibility of hydrolysed and epoxidized soybean oil based polymers, it finds use in a drug delivery system and pharmaceutical applications. Abdekhodaie et.al 24 reported regarding self-assembly, thermal transition, interaction with various drugs and surface activity of such soybean oil based polymer. Hydrolyzed polymers of soybean oil (HPSO) exhibited lower thermal transition temperature (T tr ) than epoxidized soybean oil (HPESO) because T tr value of the polymer in aqueous solution increases with increasing concentration.…”