Characterization of Novel Microelectrode Geometries for Detection of Neurotransmitters

Pettine, W.; Jibson, Matthew William; Chen, T.; Tobet, Stuart A.; Nikkel, P.; Henry, Charles S.

doi:10.1109/jsen.2011.2163708

Cited by 19 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microelectrodes were produced by Avago Technologies (Fort Collins, CO) using silicon‐based MOS technology and were arranged into 21 groups as previously described 32. A probe station (Micromanipulator Inc., Carson City, NV) was used to make electrical contact with the silicon microelectrode chip.…”

Section: Methodsmentioning

confidence: 99%

“…FEP tubing (0.01” ID, 0.0625” OD, IDEX Health and Science, Oak Harbor, WA) was inserted into the PDMS ports for interfacing the chip with fluid. One set of microelectrodes on the chip was imaged by optical profilometry (Figure 1D) and was previously determined to have the optimal electrode geometry among the electrodes on the chip 32. The set of electrodes used for this work is composed of eight interdigitated working electrodes, a pseudo‐reference electrode, and an auxiliary electrode.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Nitric Oxide from Chemical Donors Using CMOS Platinum Microelectrodes

et al. 2015

Self Cite

View full text Add to dashboard Cite

Electrochemical detection of NO generated from chemical donors is reported. Because NO is an important biological messenger, many donor sources and detection methods have been developed. Few reports have characterized NO donors using electrochemistry despite electrochemical techniques being sensitive and selective. Here, a CMOS platinum microelectrode array is interfaced with a microfluidic device for the electrochemical analysis of NO from (Z)‐1‐[N‐(2‐aminoethyl)‐N‐(2‐ammonioethyl)amino]diazen‐1‐ium‐1,2‐diolate (DETA/NO). The donor parent amine fouls the electrode, resulting in substantial signal loss, but an electrochemical cleaning method was developed that substantially reduces fouling and allows detection of NO between 90 nM and 1 µM.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Analysis of Nitric Oxide from Chemical Donors Using CMOS Platinum Microelectrodes

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…The range of tissues available for ex vivo examination is now providing a platform to examine key tissue interactions throughout life and across key target tissues such as the entire hypothalamic-pituitary-gonadal axis. Increasing advances in biomedical engineering make the visualization of chemical signaling events in live tissue more accessible [54, 56, 57]. Putting these new devices to work in biological contexts promises to unlock aspects of cellular communications that drive tissues to organize in development, or function in adulthood.…”

Section: Hormonal Programming In the Brain During Development: A Walkmentioning

confidence: 99%

Hormonal Programming Across the Lifespan

et al. 2012

View full text Add to dashboard Cite

Hormones influence countless biological processes across the lifespan, and during developmental sensitive periods hormones have the potential to cause permanent tissue-specific alterations in anatomy and physiology. There are numerous critical periods in development wherein different targets are affected. This review outlines the proceedings of the Hormonal Programming in Development session at the US-South American Workshop in Neuroendocrinology in August 2011. Here we discuss how gonadal hormones impact various biological processes within the brain and gonads during early development and describe the changes that take place in the aging female ovary. At the cellular level, hormonal targets in the brain include neurons, glia, or vasculature. On a genomic/epigenomic level, transcription factor signaling and epigenetic changes alter the expression of hormone receptor genes across development and following ischemic brain insult. In addition, organizational hormone exposure alters epigenetic processes in specific brain nuclei and may be a mediator of sexual differentiation of the neonatal brain. During development of the ovary, exposure to excess gonadal hormones leads to polycystic ovarian syndrome (PCOS). Exposure to excess androgens during fetal development also has a profound effect on the development of the male reproductive system. In addition, increased sympathetic nerve activity and stress during early life have been linked to PCOS symptomology in adulthood. Finally, we describe how age-related decreases in fertility are linked to high levels of nerve growth factor (NGF), which enhances sympathetic nerve activity and alters ovarian function.

show abstract

“…Electrodes can be readily miniaturized and selectivity controlled through both applied potential and electrode modification. Perhaps most importantly, advances in microelectronics make it possible to create high-density electrode arrays where each electrode is individually addressed to provide molecular spatial resolution in situ [5].…”

Section: Introductionmentioning

confidence: 99%

A low-power, offset-corrected potentiostat for chemical imaging applications

Kern

Chen

2013

2013 IEEE 4th Latin American Symposium on Circuits and Systems (LASCAS)

View full text Add to dashboard Cite

Traditional potentiostat designs often focus on high accuracy using high precision discrete components and often involve a limited number of discrete electrodes. Modern medicine and biological research require the use of high-density biosensor arrays to gain a better understanding of cellular communication in biological systems. Such applications involves hundreds or thousands of electrodes on a single silicon substrate. Each set of electrodes is supported by an independent group of circuits to allow real-time, multichannel detection and characterization of bio-signals. This paper presents a low power, offset-calibrated potentiostat design in a commercial 0.18um CMOS process for use in single-chip biosensor array applications to generate high resolution chemical images. The design uses a reusable on-chip calibration circuit to reduce amplifier offset error, with 40.3 µW of power consumption and a total silicon area of .02 mm 2 .

show abstract

Characterization of Novel Microelectrode Geometries for Detection of Neurotransmitters

Cited by 19 publications

References 21 publications

Analysis of Nitric Oxide from Chemical Donors Using CMOS Platinum Microelectrodes

Analysis of Nitric Oxide from Chemical Donors Using CMOS Platinum Microelectrodes

Hormonal Programming Across the Lifespan

A low-power, offset-corrected potentiostat for chemical imaging applications

Contact Info

Product

Resources

About