Characterization of novel MSX1 variants causally associated with non‐syndromic oligodontia in Chinese families
Ya Zhao,
Jiabao Ren,
Lingqiang Meng
et al.
Abstract:BackgroundMSX1 (OMIM #142983) is crucial to normal dental development, and variants in MSX1 are associated with dental anomalies. The objective of this study was to characterize the pathogenicity of novel MSX1 variants in Chinese families with non‐syndromic oligodontia (NSO).MethodsGenomic DNA was extracted from individuals representing 35 families with non‐syndromic oligodontia and was analyzed by Sanger sequencing and whole‐exome sequencing. Pathogenic variants were screened via analyses involving PolyPhen‐2… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.