Characterization of neutrophil‐to‐lymphocyte ratio as a measure of inflammation in rheumatoid arthritis

Chandrashekara, S; Ahmad, Masoodi Mukhtar; Panchagnula, Renuka; Anupama, K. R.; Renuka, K.

doi:10.1111/1756-185x.13157

Cited by 86 publications

(102 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent meta‐analysis showed that NLR and PLR were significantly up‐regulated in some types of rheumatic diseases including RA . Moreover, NLR and PLR were also found to be positively correlated with disease activity of RA patients, and we also found that PLR was positively correlated with CDAI and DAS28‐ESR at baseline in the present study, suggesting PLR might be used to reflect disease activity for RA patients. However, there was no significant correlation between NLR and disease activity scores, and this discrepancy might be partially owing to the different clinical and treatment background, and most of the patients included in our study had been treated with at least two cDMARDs.…”

Section: Discussionsupporting

confidence: 80%

The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

Zhou

Xiao

Qin

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

BackgroundEmerging evidence indicates that some hematological markers have critical value in evaluating treatment response. This study was performed to determine the clinical value of hemoglobin (Hb), platelet (Plt), neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ).MethodsFifty‐two RA patients receiving TCZ were recruited and followed for 6 months. The values of abovementioned hematological markers were collected. Clinical disease activity index (CDAI) and disease activity score based on 28 joints (DAS28)‐ESR were calculated. Correlation analysis was conducted by calculating Pearson's correlation coefficient. The change in disease activity between groups according to the baseline level of hematological markers was compared by t test.ResultsSignificant correlation between change in NLR (△NLR), change in PLR (△PLR), and change in CDAI (△CDAI) was found (△NLR: r = 0.30, P = 0.03; △PLR: r = 0.31, P = 0.03). The change in Plt (△Plt) was correlated with change in DAS28‐ESR (△DAS28‐ESR) (r = 0.36, P = 8.24 × 10−3). Greater improvement in CDAI was seen in patients categorized into Plt high group (t = 2.06, P = 0.04), NLR high group (t = 2.15, P = 0.04), and PLR high group (t = 2.41, P = 0.02) compared with the contrast group.ConclusionOur study demonstrated that △Plt, △NLR, and △PLR could be used to monitor the clinical response to TCZ. RA patients with high baseline levels of Plt, NLR, and PLR achieved more improvement, indicating these hematological markers might be utilized to guide TCZ treatment.

show abstract

Section: Discussionsupporting

confidence: 80%

The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

Zhou

Xiao

Qin

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…Blood NLR, which can be calculated easily using neutrophil and lymphocyte counts, has been introduced as a potential marker for inflammation in various diseases . The negative impact of elevated NLR on clinical outcome has been noted in cardiovascular disease, cancer, liver cirrhosis, and end‐stage renal disease .…”

Section: Discussionmentioning

confidence: 99%

“…Studies in patients from Western countries often used higher NLR cut‐offs than studies in patients of diverse ethnicities (e.g. Asian and African patients) . To our knowledge, no study has examined the NLR for predicting GI bleeding in Asian children.…”

Section: Discussionmentioning

confidence: 99%

“…Blood neutrophil‐to‐lymphocyte ratio (NLR) is a simple marker for systemic inflammation and can be easily determined from the differential white blood cell (WBC) count .…”

mentioning

confidence: 99%

“…Blood neutrophil-to-lymphocyte ratio (NLR) is a simple marker for systemic inflammation and can be easily determined from the differential white blood cell (WBC) count. [11][12][13][14] Some studies on HSP have reported the association of NLR with GI bleeding. 10,15 The aim of this study was therefore to assess whether NLR is a reliable marker of GI bleeding and to determine the optimal diagnostic cut-off of NLR for predicting GI bleeding in children with HSP.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Neutrophil‐to‐lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schönlein purpura

Hong

Kim

Yang

2018

Pediatrics International

View full text Add to dashboard Cite

show abstract

Immunological Characterization of Chronic Nonbacterial Osteomyelitis (CNO) in Adults: A Cross‐Sectional Exploratory Study

Leerling,

Andeweg,

Faber

et al. 2023

JBMR Plus

View full text Add to dashboard Cite

Chronic nonbacterial osteomyelitis (CNO) is a rare disease spectrum affecting children and adults. Adult CNO may occur as isolated bone inflammation, or with a broad range of extraskeletal features. CNO pathophysiology, including the key drivers of inflammation, remains largely unknown. For pediatric CNO, a role for pro‐inflammatory cytokine dysregulation has been proposed, but studies in adults are scarce. We therefore provide immunological characterization of adult CNO. Cross‐sectional study in our referral center including adult CNO patients (n = 172) and healthy controls (n = 65). Inflammation parameters and systemic inflammatory based scores(SIBS, including neutrophil/lymphocyte ratio [NLR] and systemic immune inflammation index [SII]) were compared between groups. Cytokine expression was explored with electrochemiluminescent immunoassays in 33 patients, eight healthy controls and 21 osteoporosis patients. Routine inflammation markers were higher in patients than in controls, but generally remained within reference range. Systemic inflammation was more pronounced in patients with additional vertebral involvement as compared to those osteitis in the anterior chest wall alone, in patients with comorbid pustulosis palmoplantaris or psoriasis, and in patients with strongly rather than moderately increased lesional uptake on nuclear imaging. SII was elevated in CNO patients too, but NLR was not. Cytokine expression was generally nondifferential between patients and both control groups, and patients displayed low absolute concentrations of pro‐inflammatory cytokines. In this adult CNO cohort, systemic inflammation was generally subtle, but more pronounced in patients with vertebral lesions, associated skin disease, and strongly increased uptake on nuclear imaging. SII was increased in patients compared to healthy controls. Contrasting pediatric studies, we found no increased expression of the pro‐inflammatory cytokines that have been proposed to drive the inflammatory cascade, like interleukin‐6, ‐8, and ‐17 (IL‐6, IL‐8, and IL‐17), and tumor necrosis α (TNF‐α). Further studies are needed to evaluate the use of SII in diagnosis and monitoring of CNO, and elucidate the role of cytokine dysregulation in adult disease. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.

show abstract

Characterization of neutrophil‐to‐lymphocyte ratio as a measure of inflammation in rheumatoid arthritis

Abstract: In contrast to the traditional markers, NLR may serve as a less expensive and effective measure of inflammation in RA. Its efficacy is comparable to that of CRP and it is not impacted by the cytokines influencing CRP and ESR.

Cited by 86 publications

References 24 publications

The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab

Neutrophil‐to‐lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schönlein purpura

Immunological Characterization of Chronic Nonbacterial Osteomyelitis (CNO) in Adults: A Cross‐Sectional Exploratory Study

Contact Info

Product

Resources

About