Characterization of neonates born to mothers with SARS-CoV-2 infection: Review and meta-analysis

Neef, Vanessa; Buxmann, Horst; Rabenau, Holger F.; Zacharowski, Kai; Raimann, Florian J.

doi:10.1016/j.pedneo.2020.10.001

Cited by 28 publications

(47 citation statements)

References 49 publications

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“…A meta-analysis studying 261 neonates born to mothers with COVID-19 infection showed that 10% of those neonates tested positive with PCR tests for Sars-Cov-2. Of these, 20% had light dyspnea or fever, but no serious complications [21]. Placenta, cord blood and vaginal secretions remained negative for SARS-CoV-2 with PCR tests.…”

Section: Conclusion 10mentioning

confidence: 94%

ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy

Donders

Grincevičienė

Haldre

et al. 2021

JCM

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Introduction. Sars-CoV-2 infection poses particular problems in pregnancy, as the infection more frequently causes severe complications than in unaffected pregnant women or nonpregnant women with SARS-CoV-2 infection. Now that vaccination is available and rapidly being implemented worldwide, the question arises whether pregnant women should be vaccinated, and if so, whether they should receive priority. Methods. Available scientific data and available guidelines about vaccination against SARS-CoV-2 were collected by the Guideline Committee of the International Society of Infectious Diseases in Obstetrics and Gynecology (ISIDOG) and were analyzed, discussed and summarized as guidelines for healthcare workers caring for pregnant women. Concluding statements were graded according to the Oxford evidence-based medicine grading system. Results. There is evidence to consider pregnancy as a risk factor for serious complications of COVID-19 infection, even in the absence of additional risk factors, such as hypertension, diabetes and obesity which increase these risks even more in pregnancy. Currently available data slightly favor mRNA-based vaccines above vector-based vaccines during pregnancy and breastfeeding, until more safety data become available. Conclusion. ISIDOG advises policy makers and societies to prioritize pregnant women to receive vaccination against SARS-CoV-2 and favor the mRNA vaccines until further safety information becomes available.

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Section: Conclusion 10mentioning

confidence: 94%

ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy

Donders

Grincevičienė

Haldre

et al. 2021

JCM

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“…A large study in India reported that seven out of 65 neonates tested positive for COVID-19, six of which were asymptomatic [ 54 ]. A large meta-analysis found that most neonates born to mothers with confirmed COVID-19 did not exhibit any clinical signs of SARS-CoV-2 infection [ 55 ]. A minority (42.3%) of neonates had dyspnoea and 19.1% had a fever [ 55 ].…”

Section: Effect Of Covid-19 On Neonatal Outcomesmentioning

confidence: 99%

“…A large meta-analysis found that most neonates born to mothers with confirmed COVID-19 did not exhibit any clinical signs of SARS-CoV-2 infection [ 55 ]. A minority (42.3%) of neonates had dyspnoea and 19.1% had a fever [ 55 ]. Moreover, neonates are less likely to experience complications or spend time in intensive care.…”

Section: Effect Of Covid-19 On Neonatal Outcomesmentioning

confidence: 99%

Effects of the COVID pandemic on pregnancy outcomes

Elsaddig

Khalil

2021

Best Practice & Research Clinical Obstetrics & Gynaecol

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Pregnant women and neonates are often categorised as being at high risk during the coronavirus-19 (COVID-19) pandemic. Numerous studies have demonstrated that the characteristics of COVID-19 disease in pregnant women and non-pregnant women are very similar. However, pregnant women with COVID-19 in the third trimester are more likely than their non-pregnant counterparts to require intensive care, though this may reflect a lower threshold for intervention in pregnant women rather than more serious disease. Compared with pregnant women without COVID-19, pregnant women with symptomatic COVID-19 requiring admission to hospital have worse maternal outcomes, including death, although the absolute risk remains very low. Outcomes of neonates born to women positive for COVID-19 are generally very good, though iatrogenic preterm birth is more common. Findings from these studies highlight the need for further monitoring of the outcomes of pregnant and post-partum women according to trimester during this pandemic.

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“…Newborns mortality was reported in 50 SRs, [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 25 , 34 , 35 , 36 , 39 , 40 , 41 , 43 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 59 , 60 , 62 , 63 , 64 , 65 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 76 , 77 , 78 , 79 , 80 , 82 , 84 , 85 , 87 ] and varied from 0% to 11.7% among the included reviews.…”

Section: Resultsmentioning

confidence: 99%

Vertical Transmission of SARS-CoV-2: A Systematic Review of Systematic Reviews

Musa

Bello

Zhao

et al. 2021

Viruses

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The COVID-19 pandemic has hugely impacted global public health and economy. The COVID-19 has also shown potential impacts on maternal perinatal and neonatal outcomes. This systematic review aimed to summarize the evidence from existing systematic reviews about the effects of SARS-CoV-2 infections on maternal perinatal and neonatal outcomes. We searched PubMed, MEDLINE, Embase, and Web of Science in accordance with PRISMA guidelines, from 1 December 2019 to 7 July 2021, for published review studies that included case reports, primary studies, clinical practice guidelines, overviews, case-control studies, and observational studies. Systematic reviews that reported the plausibility of mother-to-child transmission of COVID-19 (also known as vertical transmission), maternal perinatal and neonatal outcomes, and review studies that addressed the effect of SARS-CoV-2 infection during pregnancy were also included. We identified 947 citations, of which 69 studies were included for further analysis. Most (> 70%) of the mother-to-child infection was likely due to environmental exposure, although a significant proportion (about 20%) was attributable to potential vertical transmission of SARS-CoV-2. Further results of the review indicated that the mode of delivery of pregnant women infected with SARS-CoV-2 could not increase or decrease the risk of infection for the newborns (outcomes), thereby emphasizing the significance of breastfeeding. The issue of maternal perinatal and neonatal outcomes with SARS-CoV-2 infection continues to worsen during the ongoing COVID-19 pandemic, increasing maternal and neonatal mortality, stillbirth, ruptured ectopic pregnancies, and maternal depression. Based on this study, we observed increasing rates of cesarean delivery from mothers with SARS-CoV-2 infection. We also found that SARS-CoV-2 could be potentially transmitted vertically during the gestation period. However, more data are needed to further investigate and follow-up, especially with reports of newborns infected with SARS-CoV-2, in order to examine a possible long-term adverse effect.

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Characterization of neonates born to mothers with SARS-CoV-2 infection: Review and meta-analysis

Cited by 28 publications

References 49 publications

ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy

ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy

Effects of the COVID pandemic on pregnancy outcomes

Vertical Transmission of SARS-CoV-2: A Systematic Review of Systematic Reviews

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