Characterization of Native and Decellularized Porcine Tendon Under Tension and Compression: A Closer Look at Glycosaminoglycan Contribution to Tendon Mechanics
Abstract:Decellularised porcine superflexor tendon (pSFT) has been demonstrated to be a suitable scaffold for anterior cruciate ligament reconstruction[1]. While the role of collagen in tendons is well known, the mechanical role of glycosaminoglycans (GAGs) is less clear and may be altered by the decellularisation process.To determine the effects of decellularisation on pSFT GAG content and mechanical function and to investigate the consequences of GAG loss in tensile and compressive loading.pSFTs were decellularised f… Show more
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