Characterization of muscle development and gene expression in early embryos of chicken, quail, and their hybrids

Zhu, Mengting; Wang, Mingyuan; Shao, Yanyan; Nan, Ying; Blair, Hugh T.; Morris, S. T.; Zhao, Zhangwu; Zhang, Hongmei

doi:10.1016/j.gene.2020.145319

Cited by 17 publications

(18 citation statements)

References 31 publications

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“…In our previous study concerning pectoral muscles of STE and WZE, we found that STE had a significantly higher myofiber density during E15–P1 and a significantly larger myofiber diameter at E15 than WZE [ 2 ], indicating that embryonic leg and pectoral muscle development of WZE and STE showed different patterns. In our previous studies concerning pigs of different body sizes, as well as chicken and quail, it was found that embryonic muscle development was slower in breeds/species with a larger body size, which was inconsistent with the observations in geese [ 17 , 21 ]. Therefore, embryonic muscle development patterns of goose breeds differing in body size may be different from those in the aforementioned species.…”

Section: Discussionmentioning

confidence: 64%

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Zhang

Zhu

et al. 2023

IJMS

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Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. In this study, whole genome bisulfite sequencing (WGBS) was conducted on leg muscle tissue from Wuzong (WZE) and Shitou (STE) geese on embryonic day 15 (E15), E23, and post-hatch day 1. It was found that at E23, the embryonic leg muscle development of STE was more intense than that of WZE. A negative correlation was found between gene expression and DNA methylation around transcription start sites (TSSs), while a positive correlation was observed in the gene body near TTSs. It was also possible that earlier demethylation of myogenic genes around TSSs contributes to their earlier expression in WZE. Using pyrosequencing to analyze DNA methylation patterns of promoter regions, we also found that earlier demethylation of the MyoD1 promoter in WZE contributed to its earlier expression. This study reveals that DNA demethylation of myogenic genes may contribute to embryonic leg muscle development differences between Wuzong and Shitou geese.

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Section: Discussionmentioning

confidence: 64%

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Zhang

Zhu

et al. 2023

IJMS

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“…The fusion of myoblasts into myotubes is a critical phase in the formation of skeletal muscle, occurring both during embryonic myogenesis and postnatal muscle regeneration and repair [ 59 ]. Fusion, similar to other processes in myogenesis, needs extremely precise spatial and temporal manipulation [ 60 ].…”

Section: Mirna Modulates Skeletal Muscle In Domestic Chickenmentioning

confidence: 99%

Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Shi

et al. 2022

Genes

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Chicken is the most widely consumed meat product worldwide and is a high-quality source of protein for humans. The skeletal muscle, which accounts for the majority of chicken products and contains the most valuable components, is tightly correlated to meat product yield and quality. In domestic chickens, skeletal muscle growth is regulated by a complex network of molecules that includes some non-coding RNAs (ncRNAs). As a regulator of muscle growth and development, ncRNAs play a significant function in the development of skeletal muscle in domestic chickens. Recent advances in sequencing technology have contributed to the identification and characterization of more ncRNAs (mainly microRNAs (miRNAs), long non-coding RNAs (LncRNAs), and circular RNAs (CircRNAs)) involved in the development of domestic chicken skeletal muscle, where they are widely involved in proliferation, differentiation, fusion, and apoptosis of myoblasts and satellite cells, and the specification of muscle fiber type. In this review, we summarize the ncRNAs involved in the skeletal muscle growth and development of domestic chickens and discuss the potential limitations and challenges. It will provide a theoretical foundation for future comprehensive studies on ncRNA participation in the regulation of skeletal muscle growth and development in domestic chickens.

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“…Accounting for approximately 40% of an animal's body weight, the skeletal muscle is the organism's largest motor and metabolic organ and plays a vital role in metabolism and energy balance (Mayeuf-Louchart et al, 2015;Cong et al, 2020). Embryonic myogenesis and postnatal muscle development are precisely regulated by multiple mechanisms that involve myoblast progenitor cell proliferation, differentiation, and fusion to form muscle fibers (Zhu et al, 2021). Skeletal muscle development involves multiple stages of proliferation and differentiation, and research on its formation process and molecular regulation mechanisms has always been a hot topic in the field of molecular genetics.…”

Section: Introductionmentioning

confidence: 99%

Regulatory role of RNA N6-methyladenosine modifications during skeletal muscle development

Liu

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Functional cells in embryonic myogenesis and postnatal muscle development undergo multiple stages of proliferation and differentiation, which are strict procedural regulation processes. N6-methyladenosine (m6A) is the most abundant RNA modification that regulates gene expression in specific cell types in eukaryotes and regulates various biological activities, such as RNA processing and metabolism. Recent studies have shown that m6A modification-mediated transcriptional and post-transcriptional regulation plays an essential role in myogenesis. This review outlines embryonic and postnatal myogenic differentiation and summarizes the important roles played by functional cells in each developmental period. Furthermore, the key roles of m6A modifications and their regulators in myogenesis were highlighted, and the synergistic regulation of m6A modifications with myogenic transcription factors was emphasized to characterize the cascade of transcriptional and post-transcriptional regulation during myogenesis. This review also discusses the crosstalk between m6A modifications and non-coding RNAs, proposing a novel mechanism for post-transcriptional regulation during skeletal muscle development. In summary, the transcriptional and post-transcriptional regulatory mechanisms mediated by m6A and their regulators may help develop new strategies to maintain muscle homeostasis, which are expected to become targets for animal muscle-specific trait breeding and treatment of muscle metabolic diseases.

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Characterization of muscle development and gene expression in early embryos of chicken, quail, and their hybrids

Cited by 17 publications

References 31 publications

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Regulatory role of RNA N6-methyladenosine modifications during skeletal muscle development

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