Characterization of murine interferon-alpha 12 (MuIFN-α12): Biological activities and gene expression

Tsang, Sai Leong; Leung, Po Chu; Leung, Ka Kit; Yau, Wai Lok; Hardy, Matthew P.; Mak, Nai Ki; Leung, Kwok Nam; Fung, Ming Chiu

doi:10.1016/j.cyto.2007.03.002

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…The IFN genes (including pseudogenes) in cattle include 10-12 IFN-␣, 5-6 IFN-␤, 3-5 IFN-, and 15-20 IFN- (Capon et al, 1985;Chaplin et al, 1996;Velan et al, 1985). Despite the high degree of identity among IFN subtypes from the same species, the function and magnitude of their biological activities differ; for example, different antiviral activities between intact PoIFN-␣ and C-terminal-deleted PoIFN-␣ and unusual characteristics of murine IFN-␣13 (Cheng et al, 2006;Tsang et al, 2007;van Pesch and Michiels, 2003;Zhao et al, 2009).…”

Section: Discussionmentioning

confidence: 97%

Characterization and antivirus activities of a novel bovine IFN-omega24

Luo

Guo

Bao

et al. 2015

Molecular Immunology

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Section: Discussionmentioning

confidence: 97%

Characterization and antivirus activities of a novel bovine IFN-omega24

Luo

Guo

Bao

et al. 2015

Molecular Immunology

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“…Differences in cecum gene expression between parental alleles of the BXD were found for two members of type I interferon (IFN-α) family of cytokines, Ifna12 and Ifnab , with the later being rich in non-synonymous SNPs. There is limited information about the biological role of Ifnab but detailed analysis of Ifna12 indicated that it has functional characteristics of type I IFN-α proteins [49]. In combination with other mediators such as TNF-α and IL-12, IFN-α is produced in response to microbial products and modulate innate and adaptive immune response [50], [51].…”

Section: Discussionmentioning

confidence: 99%

Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits

et al. 2012

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The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic factors that explain differences in gut microbiota and its impact on metabolic traits. Molecular profiling of the gut microbiota revealed important quantitative differences in microbial composition among BXD strains. These differences in gut microbial composition are influenced by host-genetics, which is complex and involves many loci. Linkage analysis defined Quantitative Trait Loci (QTLs) restricted to a particular taxon, branch or that influenced the variation of taxa across phyla. Gene expression within the gastrointestinal tract and sequence analysis of the parental genomes in the QTL regions uncovered candidate genes with potential to alter gut immunological profiles and impact the balance between gut microbial communities. A QTL region on Chr 4 that overlaps several interferon genes modulates the population of Bacteroides, and potentially Bacteroidetes and Firmicutes–the predominant BXD gut phyla. Irak4, a signaling molecule in the Toll-like receptor pathways is a candidate for the QTL on Chr15 that modulates Rikenellaceae, whereas Tgfb3, a cytokine modulating the barrier function of the intestine and tolerance to commensal bacteria, overlaps a QTL on Chr 12 that influence Prevotellaceae. Relationships between gut microflora, morphological and metabolic traits were uncovered, some potentially a result of common genetic sources of variation.

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“…Evidence of this includes studies in the Friend retrovirus (FV) model, which showed that treatment with distinct IFN-␣ subtypes induced specific downstream responses that effectively controlled FV infections, whereas other subtypes induced responses that were ineffective (7,8). Furthermore, murine herpesvirus or influenza virus infections were controlled by different subtypes than those inhibiting FV (9)(10)(11)(12)(13). Recent in vitro work demonstrated not only differential relative expression of IFN-␣ subtypes in human plasmacytoid dendritic cells (pDCs) after human immunodeficiency virus type 1 (HIV-1) exposure, but also variable HIV-1 antiviral potencies of IFN-␣ subtypes in gut lamina propria mononuclear cell (LPMC) cultures (14).…”

mentioning

confidence: 99%