Characterization of Multiple Organ Dysfunction Syndrome in Very Low Birthweight Infants: A New Sequential Scoring System

Janota, J; Straňák, Z; Statecna, Barbora; Dohnalová, A; Šípek, A; Šimák, Jan

doi:10.1097/00024382-200115050-00003

Cited by 28 publications

(45 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Janota et al 7 developed the Neonatal Multiple Organ Dysfunction (NEOMOD) score that characterizes the severity of dysfunction in very low birth weight (VLBW) infants in 7 representative organ systems (eg, central nervous system, gastrointestinal, respiratory, renal, coagulation, cardiovascular, and acid-base balance). They evaluated the infant's condition at 24-hour intervals in the first 28 days of life by using this simple continuous daily scoring system and suggested that NEOMOD scores might be used to evaluate the severity of MODS and risk of death in VLBW infants.…”

mentioning

confidence: 99%

“…Previously, both Smith et al 8 and Avanoglu et al 9 reported that microvascular system involvement characterized by edema and unexplained persistent weight gain might be the earliest signs of MODS in neonates. However, Janota et al 7 did not evaluate microvascular system involvement in the NEOMOD scoring system. Moreover, some of the criteria of the NEOMOD scoring system were insufficient for diagnosis of MODS in premature infants.…”

mentioning

confidence: 99%

“…As the number of infants admitted to NICUs increase, the number of infants in whom MODS develops will also increase. So, we aimed to develop a modified scoring system combining different criteria from previous studies, [7][8][9] with the idea of detecting MODS in infants earlier and more accurately so as to decrease mortality and associated morbid conditions due to MODS.…”

mentioning

confidence: 99%

See 2 more Smart Citations

A New Scoring System For Evaluation of Multiple Organ Dysfunction Syndrome in Premature Infants

Çetınkaya

Köksal

Özkan

2012

American Journal of Critical Care

View full text Add to dashboard Cite

Background The Neonatal Multiple Organ Dysfunction (NEO-MOD) scoring system is used to predict mortality in infants with multiple organ dysfunction syndrome (MODS). The NEOMOD scoring system was extended to include involvement of the microvascular system. This modified scoring system was developed to enable more accurate and earlier diagnosis of MODS in premature infants. Objective To evaluate the modified NEOMOD scoring system in preterm infants with MODS and compare its effectiveness with the NEOMOD scoring system. Methods This prospective study was performed in a tertiary neonatal intensive care unit. A total of 198 premature infants were enrolled. Infants were evaluated for development of MODS by using the modified NEOMOD scoring system until discharge or death according to clinical and laboratory findings. Infants who had organ dysfunction in 2 or more organ systems had MODS diagnosed. Results In the 160 infants (80.8%) with MODS, the gastrointestinal system, respiratory system, and hematologic system were involved most often. The gastrointestinal system, respiratory system, and acid-base metabolism were involved initially in 99.4%, 86.3%, and 26.3% of infants, respectively. The mean modified NEOMOD score for the infants who died in the first 28 days after birth was significantly higher than the mean score for infants who survived. The number of systems involved was also higher in infants who died. Conclusions The modified NEOMOD scoring system is a safe and accurate tool for determining both mortality rate and dysfunction of multiple organ systems affecting mortality in preterm infants.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

A New Scoring System For Evaluation of Multiple Organ Dysfunction Syndrome in Premature Infants

Çetınkaya

Köksal

Özkan

2012

American Journal of Critical Care

View full text Add to dashboard Cite

show abstract

“…Illness severity and mortality risk scores for neonatal intensive care represent reliable means capable of predicting morbidity and mortality in VLBW neonates. [10][11][12][13][14][15] Illness severity scores for newborns are complex systems with validations and calibrations restricted by birth weight. CRIB II provides a recalibrated and simplified scoring system aiming to avoid the potential problems of early treatment bias.…”

Section: Introductionmentioning

confidence: 99%

Serum cortisol values, superior vena cava flow and illness severity scores in very low birth weight infants

et al. 2010

View full text Add to dashboard Cite

Objective: Recent evidence suggests that high cortisol concentrations are associated with increased morbidity and mortality in very low birth weight (VLBW) infants. Neonatal illness severity and mortality risk scores are reliable in predicting morbidity and mortality. The objectives were (i) to assess the correlation between serum cortisol levels and clinical assessment of multi-organ dysfunction/illness severity scores (CRIB II, SNAPPE-II and neonatal multiple organ dysfunction score (NEOMOD)) in first 24 h in VLBW infants and (ii) to assess the relationship between surrogates of end organ blood flow and serum cortisol levels.Study Design: A prospective observational cohort study. Neonates with birth weight <1500 g were eligible for enrollment. Echocardiography evaluation of superior vena cava (SVC) flow was carried out in the first 24 h life. Cortisol levels were measured simultaneously and appropriate clinical scores were calculated.Result: A total of 54 VLBW neonates were enrolled following parental consent. Two patients were excluded because of congenital malformations. In 14 babies the cortisol value was not simultaneously obtained. The mean birth weight was 1.08 kg, mean gestational age was 27.8 weeks. There was a significant correlation between cortisol and NEOMOD score (P ¼ 0.006). There was no correlation between cortisol and CRIB II score (P ¼ 0.34), SVC flow (P ¼ 0.49) and mean arterial blood pressure respectively (P ¼ 0.35). Conclusion:There was no correlation between SVC flow and cortisol values or between cortisol and mean blood pressure values. There was a significant correlation between cortisol levels and neonatal organ dysfunction score evaluated suggesting that stressed VLBW infants do mount a cortisol response. Keywords: VLBW; neonate; cortisol; superior vena cava; blood pressure; illness severity score IntroductionThe immediate postnatal period in very low birth weight (VLBW) infants is frequently complicated by hypotension and low end-organ flow. Superior vena cava (SVC) flow has proven to be a useful marker of systemic blood flow, 1 but is not easily obtained at the bedside. Blood pressure values are readily available at the bedside and hypotension has been associated with adverse short-term and long-term outcome.2,3 A number recent studies have focused on evaluating the role of hydrocortisone therapy in hypotension and suspected adrenocortical insufficiency in the sick preterm infants during the early course of life.

show abstract

“…The NEOMOD score provides a measure of multiorgan dysfunction and has been shown to correlate with mortality when measured daily over the first 28 days. 4,5 Severity of illness scores can be limited by the timing of the measurement. Although elevated scores in the initial days of life can be helpful in identifying those infants who are at a high risk of adverse outcome, those infants with less severity of illness initially may have poor late outcome related to subsequent confounding events such as late-onset sepsis or necrotizing enterocolitis.…”

mentioning

confidence: 99%

Stress and severity of illness in very low birth weight infants: what are we measuring?

Aucott

2010

J Perinatol

View full text Add to dashboard Cite

Characterization of Multiple Organ Dysfunction Syndrome in Very Low Birthweight Infants: A New Sequential Scoring System

Cited by 28 publications

References 0 publications

A New Scoring System For Evaluation of Multiple Organ Dysfunction Syndrome in Premature Infants

A New Scoring System For Evaluation of Multiple Organ Dysfunction Syndrome in Premature Infants

Serum cortisol values, superior vena cava flow and illness severity scores in very low birth weight infants

Stress and severity of illness in very low birth weight infants: what are we measuring?

Contact Info

Product

Resources

About