Characterization of multi-joint upper limb movements in a single task to assess bradykinesia

Delrobaei, Mehdi; Tran, Stephanie; Gilmore, Greydon; McIsaac, Kenneth; Jog, Mandar

doi:10.1016/j.jns.2016.07.056

Cited by 27 publications

(38 citation statements)

References 16 publications

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“…In this study, we quantified bradykinesia (slow movements) by velocity measurement, which has been reliably used in other studies in the 6-OHDA model (20,(23)(24)(25)(26). Nevertheless, there are other behavioral tests linked to bradykinesia and other motor deficits in PD (27,28), and these deserve further investigation.…”

Section: Discussionmentioning

confidence: 99%

Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control

Pan¹,

Kuo²,

Tai³

et al. 2016

Journal of Clinical Investigation

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Neuronal oscillations at beta frequencies (20-50 Hz) in the cortico-basal ganglia circuits have long been the leading theory for bradykinesia, the slow movements that are cardinal symptoms in Parkinson's disease (PD). The beta oscillation theory helped to drive a frequency-based design in the development of deep brain stimulation therapy for PD. However, in contrast to this theory, here we have found that bradykinesia can be completely dissociated from beta oscillations in rodent models. Instead, we observed that bradykinesia is causatively regulated by the burst-firing pattern of the subthalamic nucleus (STN) in a feed-forward, or efferent-only, mechanism. Furthermore, STN burst-firing and beta oscillations are two independent mechanisms that are regulated by different NMDA receptors in STN. Our results shift the understanding of bradykinesia pathophysiology from an interactive oscillatory theory toward a feed-forward mechanism that is coded by firing patterns. This distinct mechanism may improve understanding of the fundamental concepts of motor control and enable more selective targeting of bradykinesia-specific mechanisms to improve PD therapy.

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Section: Discussionmentioning

confidence: 99%

Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control

Pan¹,

Kuo²,

Tai³

et al. 2016

Journal of Clinical Investigation

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“…Upper extremity (UE) coordination deficits are commonly noted in neurological patients [1][2][3][4]. Specifically, the upper extremity is the basis of our fine motor skills, which are extremely important in the proper execution of activities of daily life [5].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of upper extremities motor function in multiple sclerosis

Daunoravičienė

Žižienė

Griškevičius

et al. 2018

THC

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“…The current standard of care in the management of movement disorders associated with PD includes subjective evaluation using the clinical gold standards such as the UPDRS [29]. In our previous work, we illustrated the subjective nature of the UPDRS motor score by revealing a weak correlation between four trained raters in scoring a randomized subset of PD participants [33].…”

Section: Limitations Of Updrsmentioning

confidence: 96%

Towards remote monitoring of Parkinson’s disease tremor using wearable motion capture systems

Delrobaei

Memar

Pieterman

et al. 2018

Journal of the Neurological Sciences

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Characterization of multi-joint upper limb movements in a single task to assess bradykinesia

Cited by 27 publications

References 16 publications

Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control

Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control

Quantitative assessment of upper extremities motor function in multiple sclerosis

Towards remote monitoring of Parkinson’s disease tremor using wearable motion capture systems

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