Characterization of Mixing in Micromixers by a Test Reaction:  Single Mixing Units and Mixer Arrays

Ehrfeld, W.; Golbig, Klaus; Hessel, Volker; Löwe, and Holger; Richter, Thomas

doi:10.1021/ie980128d

Cited by 366 publications

(268 citation statements)

References 11 publications

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“…A home made image acquisition program allows us to take pictures at a given frame rate. When three fluids are used, a mixing device (SIMM-V2, IMM) is added before the chip to increase the efficiency of the mixing (Ehrfeld et al 1999). This device divides the two fluid streams into multiple streams and recombines them in order to increase the contact surface between the two fluids.…”

Section: Set Upmentioning

confidence: 99%

Towards a continuous microfluidic rheometer

Guillot

Moulin

Kötitz

et al. 2008

Microfluid Nanofluid

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In a previous paper we presented a way to measure the rheological properties of complex fluids on a microfluidic chip (Guillot et al., Langmuir 22:6438, 2006). The principle of our method is to use parallel flows between two immiscible fluids as a pressure sensor. In fact, in a such flow, both fluids flow side by side and the size occupied by each fluid stream depends only on both flow rates and on both viscosities. We use this property to measure the viscosity of one fluid knowing the viscosity of the other one, both flow rates and the relative size of both streams in a cross-section. We showed that using a less viscous fluid as a reference fluid allows to define a mean shear rate with a low standard deviation in the other fluid. This method allows us to measure the flow curve of a fluid with less than 250 lL of fluid. In this paper we implement this principle in a fully automated set up which controls the flow rate, analyzes the picture and calculates the mean shear rate and the viscosity of the studied fluid. We present results obtained for Newtonian fluids and complex fluids using this set up and we compare our data with cone and plate rheometer measurements. By adding a mixing stage in the fluidic network we show how this set up can be used to characterize in a continuous way the evolution of the rheological properties as a function of the formulation composition. We illustrate this by measuring the rheological curve of four formulations of polyethylene oxide solution with only 1.3 mL of concentrated polyethylene oxide solution. This method could be very useful in screening processes where the viscosity range and the behavior of the fluid to an applied stress must be evaluated.

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Section: Set Upmentioning

confidence: 99%

Towards a continuous microfluidic rheometer

Guillot

Moulin

Kötitz

et al. 2008

Microfluid Nanofluid

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“…As one of the most important methods to intensify micromixing, microscale devices such as micromixers and microreactors have attracted increasing attention in both laboratories and commercial areas in recent years (Ehrfeld et al, 1999;Hessel and Löwe, 2003;Wiles andWatts, 2008, Wong et al, 2004). The values of Reynolds number are usually low in microstructure devices due to their small characteristic dimension; therefore, the flow in micromixers and microreactors is generally within the laminar flow regime, and the mixing is mainly driven by the molecular diffusion.…”

Section: Introductionmentioning

confidence: 99%

“…The rapid mixing was realized by the collision of microfluidic segments, which were divided into several radial streams at the center of mixer. Ehrfeld et al (1999) fabricated an interdigital micromixer with channel characteristic size of only 25 mm, and the fast mixing was obtained by using the principle of multilamination. Wong et al (2004) demonstrated that the swaying of the fluids in the complicated twisted microchannel caused chaotic advection, hence improved the micromixing performance.…”

Section: Introductionmentioning

confidence: 99%

Ideal micromixing performance in packed microchannels

Chen

Yuan

2011

Chemical Engineering Science

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“…[166] Such MF reactors have played a significant role in improving the reaction conditions and production of chemicals. [167] In contrast with conventional batch systems, the use of MF to study and optimize the fabrication of a wide range of nanoparticles is attracting more and more attention [167] and their use for chemical synthesis gained a quick development with notable contributions from researchers at GlaxoSmithKline (UK), [168] Massachusetts Institute of Technology (USA), [169] the Institut für Mikrotechnik Mainz (Germany) [170] and Imperial College London (UK). [171] Since the first use of MF to prepare Cd nanoparticles on a lab-on-a-chip device, [172] advancement in the area of chemical synthesis of nanomaterials has been accelerated over the past decade.…”

Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Characterization of Mixing in Micromixers by a Test Reaction: Single Mixing Units and Mixer Arrays

Cited by 366 publications

References 11 publications

Towards a continuous microfluidic rheometer

Towards a continuous microfluidic rheometer

Ideal micromixing performance in packed microchannels

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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